Psychosis-risk Outcomes Network (ProNET)
ProNET: Psychosis-Risk Outcomes Network
['FUNDING_U01'] · YALE UNIVERSITY · NIH-11493635
This project follows people at clinical high risk for psychosis across many centers to link brain, genetic, biological, and smartphone-based signals with symptom courses over two years.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11493635 on ClinicalTrials.gov |
What this research studies
If you join, you would be seen at one of 26 international ProNET sites for repeated visits and tests over 24 months. The project enrolls about 1,040 people at clinical high risk for psychosis and 260 healthy volunteers for comparison. Researchers collect MRI and EEG scans, blood and other body-fluid samples, genetic data, cognitive and symptom tests, recorded speech, and passive smartphone sensor data at multiple timepoints. Some measures are repeated to map how brain and behavior change over time and how those changes relate to clinical outcomes.
Who could benefit from this research
Good fit: Ideal candidates are people identified as being at clinical high risk for psychosis (recent, subthreshold or attenuated psychotic symptoms) who can attend repeated in-person assessments and give biological samples.
Not a fit: People already diagnosed with a full psychotic disorder or those unable or unwilling to complete scans, blood draws, or smartphone-based monitoring are unlikely to benefit directly from participation.
Why it matters
Potential benefit: If successful, this work could help identify early warning signs and tailor interventions to prevent or lessen psychotic disorders.
How similar studies have performed: Smaller single-site studies have found promising biomarkers for psychosis risk, but this large, multi-site, multi-modal network is novel in scale and scope.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WOODS, SCOTT W — YALE UNIVERSITY
- Study coordinator: WOODS, SCOTT W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.