Predicting psychotic relapse using speech analysis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to develop and validate a digital model that predicts relapses in individuals with early psychosis by analyzing their speech patterns. Utilizing natural language processing tools, the study will assess changes in speech coherence, connectedness, and complexity to identify imminent relapses up to four weeks in advance. Conducted across Early Psychosis Intervention clinics in Ontario and Quebec, the research will also explore the model's effectiveness across different languages and genders. A total of 250 first-episode psychosis patients will be recruited for this longitudinal study.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age must be 16 years and older
* Diagnosis must meet DSM-5 criteria for psychotic disorders, including schizophrenia, schizoaffective disorder, or related conditions
* Fluency in English or French
* Must be currently receiving treatment through an EPI program

Exclusion Criteria:

* Severe comorbid speech or language disorders (e.g., aphasia)
* Primary diagnosis of non-psychotic disorders
* Inability to provide consent or complete assessments

Where it's running

• Robarts Research Institute
  London, Ontario, Canada Recruiting
• Douglas Mental Health University Institute
  Montreal, Quebec, Canada Recruiting
• Vitam
  Québec, Quebec, Canada Recruiting

Study contacts

• Study coordinator: Lena Palaniyappan, MD, PHD
• Email: lena.palaniyappan@mcgill.ca
• Phone: 5147616131

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.