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Clinical trials and research at Vanderbilt University Medical Center

• 116Clinical trials
• 1172NIH research projects
• 3Countries

Newest trials

All recruiting trials (116)

• Parasite and Infestation Experience: Understanding What People Feel and Think

  This observational study tests how people who strongly believe they have parasites or infestation feel and think, even when doctors say otherwise.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07849907

• Corticosteroid for Diabetic Macular Edema (DME) in Adults with Diabetic Retinopathy

  This trial tests whether intravitreal corticosteroid injections can influence inflammatory biomarkers and improve DME in adults with type 2 diabetes.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT07843849

• Non-invasive test to predict early heart rejection in pediatric transplant patients

  This study tests non-invasive heart tests like cardiac MRI and blood markers to see if they can detect rejection in kids after heart transplant, potentially reducing the need for invasive biopsies.

  Recruiting at 22 sites Vanderbilt University Medical Center · Little Rock, Arkansas and 21 other locations · NCT07770659

• AR-guided resection planning for head and neck tumors

  Aims to see if augmented reality guidance can help surgeons perform more precise re-sections in head and neck tumor cases using cadaver specimens.

  Recruiting Early Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT07686211

• Modeling heart failure in Duchenne and Becker muscular dystrophy to find surrogate heart measures

  This study will look at heart disease in people with Duchenne/Becker muscular dystrophy and carriers to see if MRI-based heart measures can predict death or major heart problems.

  Recruiting at 9 sites Vanderbilt University Medical Center · Sacramento, California and 8 other locations · NCT07674758

• Cirrhotic Cardiomyopathy in Adults: A Prospective multicenter look

  This study tests whether adults with decompensated cirrhosis often have hidden heart problems and whether bile acids in the blood are linked to those heart changes.

  Recruiting at 2 sites Vanderbilt University Medical Center · Nashville, Tennessee and 1 other locations · NCT07658222

• Neural basis of working memory in people with memory disorders

  Researchers will test how brain activity during working memory tasks relates to memory problems by recording brain signals from depth electrodes during seizure monitoring.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07617506

• Ultrasound-Guided Lumbar Puncture to Improve CSF Yield in Infants

  A study to test whether using ultrasound during lumbar puncture in newborns and infants helps obtain usable CSF on the first try.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07612644

• IsoLG scavenger 2-HOBA for salt sensitivity of blood pressure

  This study tests whether the IsoLG scavenger 2-HOBA can reduce salt sensitivity and immune activation in adults with salt-sensitive hypertension.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT07602166

• Educational podcast for people with chronic pelvic pain and endometriosis

  This project will test whether giving adults with chronic pelvic pain or endometriosis access to an educational podcast along with their usual care helps improve quality of life, reduce stigma, or increase satisfaction with care compared with usual care alone.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07568834

• Nicotinamide riboside for combined pulmonary hypertension

  This study tests whether nicotinamide riboside (a form of vitamin B3 that raises NAD+) can help adults with combined pre- and post-capillary pulmonary hypertension (CPH).

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07563322

• Suction versus water-seal chest tube management for traumatic hemothorax/hemopneumothorax

  This trial will try whether starting chest tubes on suction or keeping them on a water seal helps adults with traumatic hemothorax or hemopneumothorax get their tubes out sooner and recover faster.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07551791

• Decision aid to support choices for coronary artery anomalies

  This study tests a decision aid to help English-speaking patients 10-35 and their families weigh management options for R-AAOCA without ischemia.

  Recruiting Vanderbilt University Medical Center · Boston, Massachusetts and 4 other locations · NCT07544979

• Survey of physical activity and quality of life for people with fibromuscular dysplasia

  This national survey asks adults with fibromuscular dysplasia to see if activity restrictions affect their quality of life and emotional well-being.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07529691

• Antibiotics or placebo for acute uncomplicated diverticulitis in diverse US patients

  This study tests whether antibiotics help people with acute uncomplicated diverticulitis, compared with a placebo, in diverse patients treated in US emergency departments.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT07492134

• Endoscopic Oxygen Monitoring During Colorectal Connections

  This study tests a new endoscopic device that shows real-time tissue oxygen levels to help surgeons evaluate perfusion at the bowel connection in adults undergoing colorectal surgery.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07467980

• Community TMS to reduce opioid craving and support recovery

  This program tests whether repetitive transcranial magnetic stimulation (TMS) can reduce craving and opioid use in adults on buprenorphine who have recently returned to opioid use.

  Recruiting at 2 sites Vanderbilt University Medical Center · Brentwood, Tennessee and 1 other locations · NCT07457489

• How the brain signals reward and risk in Parkinson's disease

  This project will record brain signals during deep brain stimulation surgery to see how reward-seeking and risk-taking work in people with Parkinson's disease who are having electrodes placed.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07409207

• Empowered Relief to improve recovery after lumbar spine surgery

  This project will test if a single remote Empowered Relief session helps adults 18–75 recover better after lumbar spine surgery than a single remote education session.

  Recruiting Vanderbilt University Medical Center · Honolulu, Hawaii and 3 other locations · NCT07406997

• Storing deceased donor kidneys at 10°C instead of on ice (4°C)

  This trial will try to see if deceased donor kidneys stored at 10°C help adult transplant recipients have better kidney function after transplant compared with kidneys stored on ice (4°C).

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07385651

• Guided electronic tools to help clinicians manage MASLD

  Aimed at testing whether an electronic decision support tool used in primary care and specialty settings can help clinicians better manage MASLD in adults.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07382349

• Ketone drink to see if it helps ICU delirium in adults

  A ketone supplement given by mouth or feeding tube is being tested to see if it can reduce delirium duration or occurrence in adults in the ICU compared with a placebo.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT07364162

• Make germline genetic testing easier for people with breast, pancreatic, or colorectal cancer

  This project tries a set of clinic changes to see if oncology teams will order more germline genetic tests for people with breast, pancreatic, or colorectal cancer.

  Recruiting at 10 sites Vanderbilt University Medical Center · Los Angeles, California and 9 other locations · NCT07307664

• Cyclic vs Static Manual Aspiration for Acute Large Vessel Occlusion Stroke

  A randomized trial tests whether cyclic (plunger) suction or continuous suction works better to remove clots in adults with acute ischemic stroke from large vessel blockage.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07231380

• 2-HOBA for Lupus: A 2-period crossover study to see if scavenging IsoLGs lowers blood pressure

  This phase II study tests whether 2-HOBA taken three times daily can reduce blood pressure and immune activation in adults with systemic lupus erythematosus compared to placebo.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT07225543

• Perioperative Lidocaine in Enhanced Recovery After Major Non-Cardiac Surgery

  This trial tests whether giving IV lidocaine during major non-cardiac surgery helps recovery and reduces opioid use in adults within an ERAS program.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT07224711

• Intraoperative oxygen levels and postoperative outcomes in adults

  This project will try three different amounts of oxygen during general anesthesia to see which one leads to fewer organ injuries or deaths in adults having surgery with a breathing tube.

  Recruiting at 4 sites Vanderbilt University Medical Center · Ann Arbor, Michigan and 3 other locations · NCT07224243

• Single-port robotic DIEP flap harvest for breast reconstruction

  This project will test whether a single-port robotic technique can safely and effectively harvest DIEP flaps for adults having breast reconstruction.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07222514

• Semaglutide to reduce drinking, smoking, and heart disease risk in people with HIV

  This trial tests whether the diabetes drug semaglutide can help adults living with HIV drink less alcohol, smoke fewer cigarettes, and lower their heart disease risk.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT07221214

• Improving math and working memory in first graders with math learning disabilities

  This project will test whether adding computerized working memory training to a validated math word-problem program helps first graders with math learning disabilities improve math skills more than the math program alone.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07220746

• Voice app to help NICU mothers connect with their babies (NURTURE)

  This trial will test whether the VoiceLove mobile app helps mothers with infants in the NICU have less postpartum depression compared with usual care.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07214597

• Precision brain stimulation to reduce cannabis craving in people with schizophrenia

  This trial tests whether targeted brain stimulation can reduce cannabis craving and improve thinking in people with schizophrenia who currently use cannabis.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07196462

• High-dose versus standard-dose flu vaccine for lung transplant recipients

  This study will test whether two yearly doses of the high‑dose flu vaccine produce stronger immune responses than two yearly standard‑dose flu vaccines in people who have received a lung transplant.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT07192458

• 2-HOBA to reduce persistent immune activation in Long COVID with POTS

  This trial will test whether 2‑HOBA, a compound that scavenges harmful IsoLG-adducts, can reduce immune activation in adults with Long COVID who have POTS.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT07189936

• SGLT2 inhibitor therapy for Duchenne cardiomyopathy in kids

  This study tests whether empagliflozin can be safely given to children with Duchenne muscular dystrophy to help their heart condition and understand how the drug behaves in their bodies.

  Recruiting Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT07172971

• Discovery Program for Teens and Young Adults with Type 1 Diabetes

  This project tests whether the Discovery Program—personalized mobile health messages, clinician support, and structured problem-solving—helps teens and young adults (ages 13–21) with type 1 diabetes improve blood sugar control and self-management.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07116434

• Using rose scent to reduce breathing pauses during seizures

  This study will test whether continuous exposure to rose scent can reduce breathing pauses (ictal apnea) during seizures in adults with epilepsy who are being monitored in the hospital.

  Recruiting Early Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT07116421

• See if same day discharge after bariatric surgery is safe for select patients

  This trial tests whether people having sleeve gastrectomy or gastric bypass can go home the same day or should stay at least one night, to see if ER visits within a week differ.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT07011628

• AI-driven clinical decision support to reduce hospital-acquired blood clots

  This project will test whether an automated AI tool that flags hospitalized adults at risk can help clinicians prevent hospital-acquired blood clots at Vanderbilt hospitals.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06939803

• Tracking how labeled glucose is used by immune cells in real time

  Adults will receive a short infusion of safe, non-radioactive labeled glucose while researchers take blood immune cells to see how those cells use glucose for energy and as building material.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06930976

• VoiceLove app to improve communication, family engagement, and delirium in critically ill adults

  This trial will test whether the VoiceLove phone app helps families communicate with intubated adults in the medical or coronary ICU and whether it improves family engagement and reduces ICU delirium.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06923462

• Using continuous glucose monitors for diabetes management after hospital discharge

  This study is testing if using continuous glucose monitors can help adults with diabetes manage their blood sugar better after leaving the hospital.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06852950

• Examining how psychotherapy affects paranoia in schizophrenia

  This study is testing whether psychotherapy can help people with schizophrenia feel less paranoid and change how they think about their surroundings.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06835556

• Reducing unnecessary antibiotic use in children with respiratory infections

  This study is testing whether using a new support system in hospitals can help reduce unnecessary antibiotic prescriptions for kids with respiratory infections like pneumonia and bronchiolitis.

  Recruiting Vanderbilt University Medical Center · Oakland, California and 2 other locations · NCT06788093

• Assessing cardiovascular health after preeclampsia

  This study looks at the heart health of women who had preeclampsia during pregnancy to see if it affects their cardiovascular risks later on.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06741436

• Investigating swallowing issues in adults with and without Alzheimer's disease

  This study is testing how swallowing problems differ between adults with Alzheimer's disease and healthy older adults to see how it affects both the patients and their caregivers.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06678100

• Evaluating the effectiveness of different intensities of behavioral interventions for childhood obesity

  This study is testing how different amounts of support for healthy habits can help children aged 5-17 with obesity feel better and improve their health.

  Recruiting at 2 sites Vanderbilt University Medical Center · Baton Rouge, Louisiana and 1 other locations · NCT06654323

• Evaluating Baricitinib for Long COVID Symptoms

  This study is testing if the medication baricitinib can help adults with Long COVID feel better physically and mentally compared to a placebo.

  Recruiting at 17 sites Phase 3 Vanderbilt University Medical Center · Tucson, Arizona and 16 other locations · NCT06631287

• New imaging technology for diagnosing retinopathy of prematurity in infants

  This study is testing a new imaging technology to help doctors better see and understand eye problems in premature infants with retinopathy of prematurity.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06612541

• Reducing high insulin levels to improve heart and blood sugar health in type 1 diabetes

  This study is testing whether a new medication can help people with type 1 diabetes lower their insulin levels to improve their heart and blood sugar health.

  Recruiting Early Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT06609356

• Understanding the experiences of adolescents with tic disorders

  This study looks at the experiences of teenagers with tic disorders to see how their tics and other feelings affect their daily lives and mental health.

  Recruiting Vanderbilt University Medical Center · Nashvile, Tennessee · NCT06576726

• Identifying risks of dangerous heart rhythms in genetic heart conditions

  This study is trying to see if special heart tests can help find people with genetic heart conditions who are at risk for serious heart rhythm problems.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06575881

• Mobile health program to boost exercise in teens with pulmonary arterial hypertension

  This study is testing a mobile health program to see if it can help teenagers with pulmonary arterial hypertension get more exercise.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06549452

• Adapting obesity interventions for children in community settings

  This study is testing a new version of a family-focused program to help children in underserved communities manage their weight better and see if it works better than the original program.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06546696

• Preventing strokes in children with sickle cell disease in Nigeria using hydroxyurea

  This study is testing if hydroxyurea can help prevent strokes in children with sickle cell disease in Nigeria who are at high risk.

  Recruiting at 2 sites Phase 4 Vanderbilt University Medical Center · Kano and 1 other locations · NCT06526117

• Understanding risk factors and biomarkers in ARDS, sepsis, and pneumonia

  This study is trying to find out what causes acute respiratory distress syndrome, sepsis, and pneumonia by collecting health information and samples from hospitalized adults to help improve treatment for these conditions.

  Recruiting at 20 sites Vanderbilt University Medical Center · Fresno, California and 19 other locations · NCT06521502

• Behavioral intervention to improve sleep for adolescents with type 1 diabetes

  This study is testing whether a coaching program can help teenagers with type 1 diabetes sleep better and see if that improves their blood sugar control and thinking skills.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06516614

• Predicting the risk of postpartum hemorrhage during childbirth

  This study tests a new computer model that predicts the risk of heavy bleeding after childbirth to help doctors take better care of new moms.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06513351

• Be SMART secure firearm storage counseling for hospitalized caregivers

  This program will test whether a short Be SMART video and handout help caregivers of hospitalized children store firearms more safely at home.

  Recruiting at 2 sites Vanderbilt University Medical Center · Aurora, Colorado and 1 other locations · NCT06485141

• Using traditional healers to offer HIV testing and counseling instead of standard clinic-based care in rural South Africa

  This project will test whether training traditional healers to offer free HIV counseling, testing, and linkage services helps more adults in rural South Africa get tested and linked to care compared with standard clinic-based services.

  Recruiting Vanderbilt University Medical Center · Agincourt, MP · NCT06483854

• Text messaging support for parents after a child's psychiatric emergency

  This study is testing a text messaging program to help parents of kids and teens who just had a mental health crisis feel more supported and better navigate mental health services.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06456762

• Flushing chest drains to improve outcomes in pleural infections

  This study is testing if flushing chest drains with saline every six hours can help people with serious lung infections recover faster and spend less time in the hospital.

  Recruiting at 5 sites Vanderbilt University Medical Center · Sterling Heights, Michigan and 4 other locations · NCT06427538

• Impact of GLP-1Ra on Metabolic Outcomes in Early Stage Type 1 Diabetes

  This study is testing if a new diabetes drug can help people with early stage Type 1 Diabetes improve their blood sugar control and heart health while they are also getting another treatment.

  Recruiting Early Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT06338553

• Understanding retinal changes during pregnancy

  This study looks at how pregnancy affects the eyes by taking special pictures of the retina at different stages to help doctors better understand eye health during this time.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06311617

• Assessing pain types in treating bladder pain syndrome

  This study is trying to see how different types of bladder pain affect how well people with bladder pain syndrome respond to pelvic floor physical therapy and cognitive-behavioral therapy.

  Recruiting Vanderbilt University Medical Center · Franklin, Tennessee · NCT06299683

• Improving recovery after cervical spine surgery with early physical therapy

  This study is testing if starting physical therapy sooner after neck surgery helps people recover better than waiting a few months.

  Recruiting at 4 sites Vanderbilt University Medical Center · Honolulu, Hawaii and 3 other locations · NCT06202443

• Breathing exercises for heart transplant patients

  This study tests whether breathing exercises can help heart transplant patients recover better and improve their ability to eat and swallow after surgery.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06190171

• Using wearable technology to assess blood sugar and heart health in boys with Duchenne muscular dystrophy

  This study is testing how blood sugar levels and heart health are connected in boys with Duchenne muscular dystrophy using wearable technology to gather data.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06124196

• Using wearable technology to monitor blood sugar and heart health in boys with Duchenne Muscular Dystrophy

  This study is testing how wearable technology can help monitor blood sugar and heart health in boys with Duchenne Muscular Dystrophy to better understand their risks for heart problems.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06093100

• Reducing oxidative stress to prevent chronic pain after knee surgery

  This study is testing if a special antioxidant can help people who have knee surgery feel less pain and recover better.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT06083480

• Home-based cardiac rehabilitation after heart valve procedures

  This study tests a home-based cardiac rehab program using a mobile app to see if it helps people who have had heart valve procedures improve their health without going to a rehab center.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06077201

• Using Tranexamic Acid to Reduce Bleeding in Nasal Reconstruction

  This study is testing whether giving tranexamic acid can help reduce bleeding and improve recovery for patients having nasal reconstruction surgery.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT06057675

• How attention and cholinergic signaling work in older adults with subjective cognitive decline

  This project will test whether blocking a key brain chemical with mecamylamine disrupts attention more in older adults who feel their thinking is slipping than in those who do not, using cognitive tests and EEG.

  Recruiting Early Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT06002477

• Using artificial tears to prevent tear duct blockage after thyroid cancer treatment

  This study tests if using artificial tears can help prevent tear duct blockages in people who have had radioactive iodine treatment for thyroid cancer.

  Recruiting Phase 3 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05999630

• Comparing low-dose buccal buprenorphine to standard opioids for pain relief and abuse potential

  This study is testing if a low-dose form of buprenorphine can relieve pain and has less potential for abuse compared to the standard opioid oxycodone, using healthy volunteers.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05988710

• Effects of a diabetes medication on inflammation and heart health in obese patients

  This study tests if a diabetes medication called empagliflozin can help reduce inflammation and improve heart health in obese patients with metabolic syndrome.

  Recruiting Phase 1/2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05972564

• Training toddlers with autism to improve imitation and rhythm sensitivity

  This study is testing if adding music to a training program helps toddlers with autism learn to imitate better and if their ability to respond to rhythms affects how well they do.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT05880225

• Effects of a medication on blood vessel function and organ injury in heart surgery patients

  This study tests if a medication called vericiguat can improve blood vessel function and reduce kidney and brain injury in patients having heart surgery.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05812755

• Using tranexamic acid to reduce bleeding and swelling in rhinoplasty

  This study is testing if giving tranexamic acid during nose surgery can help reduce bleeding and swelling for patients.

  Recruiting Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05774717

• Understanding risk and resilience in pulmonary arterial hypertension

  This study is trying to understand why some people with certain genetic changes get pulmonary arterial hypertension while others don’t, by looking at different markers in their bodies over time.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT05584722

• Investigating the role of Varicella zoster virus in achalasia

  This study is testing if a treatment that targets the chickenpox virus can help people with achalasia feel better by improving how food moves from the esophagus to the stomach.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05550194

• Modifying the respiratory microbiome in cesarean-born infants using vaginal secretions

  This study is testing whether using vaginal secretions on healthy cesarean-born infants right after birth can help change their nasal bacteria for the better.

  Recruiting Early Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05505110

• Stimulation of nerves to treat obstructive sleep apnea

  This study is testing if stimulating certain nerves can help people with obstructive sleep apnea breathe better during sleep, especially for those who haven't found relief with other treatments.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT05501236

• Using CPAP to treat high blood pressure in patients with autonomic failure

  This study tests if using a CPAP machine can help people with autonomic failure lower their nighttime blood pressure when they lie down.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT05489575

• Mobile health intervention for patients with pulmonary arterial hypertension

  This study is testing whether a mobile health program using smart texts can help people with pulmonary arterial hypertension feel better and move more compared to regular care.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT05464095

• Investigating Lipid Accumulation in the Right Ventricle of Patients with Pulmonary Arterial Hypertension

  This study is trying to see how fat buildup in the right side of the heart affects the health and exercise ability of people with pulmonary arterial hypertension.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT05462574

• Using CoQ10 and exercise to improve muscle function in kidney disease patients

  This study is testing whether taking CoQ10 along with high-intensity exercise can help improve muscle strength and overall physical performance in patients with kidney disease who are on dialysis.

  Recruiting Phase 3 Vanderbilt University Medical Center · Sacramento, California and 1 other locations · NCT05422534

• Investigating blood flow changes in POTS after glucose intake

  This study is testing how eating glucose affects blood flow and symptoms in people with Postural Tachycardia Syndrome (POTS) compared to healthy individuals.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05375968

• Observational study on Alzheimer's disease and cognitive health in older adults

  This study is looking for older adults with and without memory problems to help researchers learn more about Alzheimer's disease and improve ways to prevent and treat it.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT05372172

• Using a PET tracer to study serotonin receptors in neurodegenerative diseases

  This study is testing how a new imaging method can help us understand serotonin receptors in people with neurodegenerative diseases like Parkinson's and see if a medication can improve their psychosis symptoms.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05357612

• Investigating how sympathetic blockade affects glucose production in obese hypertensive individuals

  This study is testing if a new treatment can help people who are obese and have high blood pressure improve their blood sugar levels.

  Recruiting Phase 1/2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05312892

• Using probiotics to reduce heart disease risk in people with HIV who drink heavily

  This study is testing if a probiotic pill can help improve gut health and lower heart disease risk in people with HIV who drink heavily.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05288790

• Cholinergic Integrity in Down Syndrome and Aging

  This study tests a brain imaging tracer to see if cholinergic nerve health declines with age in adults with Down syndrome who may be at risk for Alzheimer's disease.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT05231798

• Examining gut microbiota changes in patients undergoing metabolic surgery

  This study is testing how metabolic surgery affects gut bacteria and heart health in patients, especially focusing on the African American community, over the next 10 years.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT05000996

• Using 2-HOBA to improve HDL function in patients with Familial Hypercholesterolemia

  This study is testing if a new treatment called 2-HOBA can help improve cholesterol function in people with Familial Hypercholesterolemia.

  Recruiting Phase 2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT04941599

• Examining the effects of stress on adults with Tourette Syndrome

  This study looks at how stress affects adults with Tourette Syndrome over two years to see if it changes their tics, mental health, and overall quality of life.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT04851678

• Using an accelerometer to measure symptoms of neurogenic orthostatic hypotension

  This study is testing if using a device to track how long people with neurogenic orthostatic hypotension can stay upright helps show if their medication works better than a placebo.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT04782830

• Improving blood vessel function in African Americans using galantamine

  This study is testing if a medication called galantamine can improve blood vessel function and reduce stress on the blood vessels in African Americans who may be at higher risk for heart problems.

  Recruiting Phase 1/2 Vanderbilt University Medical Center · Nashville, Tennessee · NCT04769206

• Understanding brain activity in psychiatric disorders

  This study is trying to see how brain activity relates to psychiatric and memory disorders in people with epilepsy to help improve diagnosis and treatment options.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT04725409

• Understanding brain activity related to cognitive issues in Parkinson's disease

  This study is trying to see how brain activity is linked to thinking problems in people with Parkinson's disease by recording brain signals during surgery.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT04715984

• Raising the head of the bed to lower blood pressure in patients with autonomic failure

  This study is testing if raising the head of the bed can help people with autonomic failure lower their high blood pressure while lying down.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT04502225

• Using long-acting tacrolimus for lung transplant patients

  This study is testing if a new long-acting version of tacrolimus can help lung transplant patients avoid complications and protect their kidneys better than traditional medications.

  Recruiting Early Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT04469842

• Imaging with [18F]F-DOPA in patients with autonomic failure

  This study is testing a special imaging technique to see if it can help identify early signs of neurodegenerative diseases in people with autonomic failure.

  Recruiting Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT04246437

• Observing sensory symptoms in Tourette syndrome

  This study looks at how sensory symptoms affect people with Tourette syndrome over time by having them fill out questionnaires about their experiences each year.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee and 1 other locations · NCT03851484

• Evaluating diagnostic tests for Primary Ciliary Dyskinesia

  This study is testing how well nasal nitric oxide testing works for diagnosing Primary Ciliary Dyskinesia in people who are being checked for this condition.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT03704207

• Understanding Familial Pulmonary Fibrosis

  This study follows family members of people with a specific lung disease to see how the disease develops over time and what factors might increase their risk of getting pulmonary fibrosis.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT03437486

• Evaluating the ALPS Proximal Humerus Plating System for shoulder fractures

  This study is testing how well a new shoulder plate works for people with shoulder fractures by looking at their strength, movement, and pain levels after treatment.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT03328650

• Using CPAP to treat high blood pressure in patients with autonomic failure

  This study tests if using a CPAP machine at night can help lower blood pressure in patients with autonomic failure who have high blood pressure when lying down.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT03312556

• Heat application for managing high blood pressure in patients with autonomic failure

  This study is testing if using a heating pad on the belly at night can help people with autonomic failure lower their high blood pressure while lying down.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT03042988

• Effects of angiotensin-(1-7) on metabolism in obese individuals

  This study is testing if a substance called angiotensin-(1-7) can help improve metabolism and insulin sensitivity in people who are obese and have insulin resistance.

  Recruiting Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT02646475

• Understanding hormonal and metabolic factors in pulmonary arterial hypertension

  This study is trying to see how hormones like estrogen and testosterone, along with metabolic factors, affect pulmonary arterial hypertension (PAH) differently in men and women to help improve treatment options.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT01884051

• Using stereotactic radiosurgery to treat essential and Parkinsonian tremors

  This study is testing if a new type of radiation treatment can help people with essential tremor or Parkinsonian tremor feel better and improve their quality of life.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT01734122

• Identifying biomarkers in tissue and fluid samples from colorectal cancer patients

  This study is trying to find new markers in tissue and fluid samples from people with colorectal cancer and healthy volunteers to see if they can help identify cancer risk and improve screening methods.

  Recruiting at 2 sites Vanderbilt University Medical Center · Nashville, Tennessee and 1 other locations · NCT00899626

• Collecting tissue samples from head and neck cancer patients and healthy participants

  This study is collecting tissue, saliva, and blood samples from people with head and neck cancer and healthy individuals to help researchers learn more about the disease and improve treatment in the future.

  Recruiting at 4 sites Vanderbilt University Medical Center · Nashville, Tennessee and 3 other locations · NCT00898638

• Development of a brain atlas for improved treatment of neurological conditions

  This study is trying to create a detailed brain map to help doctors find the best treatment spots for patients with conditions like Parkinson's, OCD, and epilepsy.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT00575081

• Providing access to visual aids for children with vision impairment

  This study is testing a program that gives children with vision impairments in Tennessee access to special glasses and training to help them see and learn better.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT00341744

NIH-funded research (newest 40 of 1172)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Improving healthcare for patients with inherited cancer syndromes using a web-based platform

  This study is testing a new online tool called MeTree that helps people understand their risk for inherited cancer by combining their medical records and family health history, making it easier for patients and doctors to get the information they need for better care and support.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-9848671

• Stroke prevention with hydroxyurea for children with sickle cell anemia in Nigeria

  A multinational, patient-facing study tests whether hydroxyurea can safely prevent first strokes in Nigerian children with sickle cell anemia.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11629280

• Scaling Up Task-Shifted Epilepsy Care for Children in Africa

  A study to help children with epilepsy in Africa get diagnosed and receive seizure care through trained community health workers.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11625567

• Enhanced surveillance for new vaccine‑preventable diseases

  A Vanderbilt team is tracking how well vaccines work and how diseases like flu, RSV, norovirus, and SARS‑CoV‑2 affect young children over time.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11624131

• Generative AI to create private, fair health data for research

  A researcher at Vanderbilt aims to use Generative AI to create synthetic health data that protects patient privacy while helping AI models be fairer and more accurate.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11623173

• ConProject-003: A patient-facing initiative at Vanderbilt for advancing care

  A Vanderbilt-led project (ConProject-003) is funded to drive improvements in care for people with a specific health condition through a dedicated program.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11622553

• ConProject-002: A major Vanderbilt effort to advance patient care

  A Vanderbilt project aims to advance care for patients by building and applying a large, center-wide approach to a medical challenge over one year.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11622552

• Project 1: advancing care through a Vanderbilt-focused research effort

  A Vanderbilt-led effort is pursuing new ways to improve care for patients through a translational research project funded by NIH.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11622551

• Executive function and reading and math in children

  This project looks at how kids aged 7–8 use executive function skills when doing reading and math tasks and how their brain regions work together.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11619344

• RNA editing in islet function and inflammation

  This project studies how a natural RNA editing process affects the cells in the pancreas that control sugar, with potential links to inflammation and autoimmune diabetes.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11617683

• RNA editing and immune signals in pancreatic islet cells

  A study at Vanderbilt aims to understand how a cellular process called RNA editing affects immune responses in insulin-producing islet cells, potentially linking it to inflammation and type 1 diabetes.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11617682

• Spina Bifida Patient Registry at Vanderbilt

  A California-style patient registry project collects health information from kids and adults with spina bifida treated at Vanderbilt to help understand long-term outcomes.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11616598

• UMPIRE: Standardized Urologic Care for Babies with Spina Bifida

  A child with spina bifida would receive a standardized set of bladder and kidney care to protect kidneys and help with continence as they grow.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11616596

• GLP-1 receptor agonists as immune targets to treat asthma in lean and obese adults

  Aims to understand how GLP-1R‑agonist diabetes medicines may directly calm immune cells to reduce asthma in adults who are lean or obese.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11616517

• Genetic clues to developmental stuttering in people of all ages

  A large-scale genetic study aims to uncover genes linked to developmental stuttering across diverse ages, using family data, electronic records, and biobank information.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11609221

• Sahel Epilepsy Study: finding patterns in epilepsy in rural Africa and its links to genes

  A plan to study epilepsy in rural Nigeria to discover how common it is, what factors affect risk, and how genetics may influence it, with results that could improve care for people with epilepsy.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11607947

• SGLT2 inhibitors for pediatric Duchenne-related cardiomyopathy

  A pediatric-focused study tests whether a diabetes drug class (SGLT2 inhibitors) can help heart disease linked to Duchenne muscular dystrophy in children and young adults.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11607308

• Genetic clues for rhythm and language problems across life

  A study at Vanderbilt will look at how genetic risk for rhythm difficulties might predict language development from childhood through adulthood, with the aim of helping identify kids who may need language support.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11602393

• All of Us Data and Research Center supports better understanding of health and disease

  This grant funds a data hub that helps researchers use large, diverse health information to uncover factors that influence health and disease and improve prevention and treatment.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11600352

• Coordinating ARDS, Pneumonia, and Sepsis research to improve care

  A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11595454

• Coordinating a national network to put genomics into everyday care

  A national coordinating center will help hospitals use genomic medicine more reliably in routine care so patients can benefit from faster, better-organized genetic testing.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11591353

• Personalized oxygen therapy for critically ill adults

  A study tests whether customizing oxygen levels for adults on invasive ventilation can lower death rates and complications.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11579981

• Partners in Eliminating Cancer Disparities (administrative supplement)

  A US cancer partnership is seeking continued support to keep its community-focused, data-driven work moving forward to reduce cancer disparities.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11573462

• Neural signals linked to recovery from aphasia after stroke

  This grant follows people who recently had a stroke and aphasia to understand why some recover language abilities better than others.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11565238

• Probiotics to Lower Heart Disease Risk for People with HIV and Heavy Drinking

  A probiotic program is tested in people with HIV who drink heavily to see if it can improve gut health and lower markers linked to heart disease.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11550807

• All of Us Data Center to accelerate health and disease research

  A big data hub called the All of Us Data and Research Center helps researchers understand what influences health and disease so they can prevent and treat illnesses.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11550029

• HIV care and outcomes across the Americas collaboration

  A regional network is coordinating data from HIV care sites across the Americas to understand how people with HIV are doing and how to improve care.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11541790

• HIV Care and Outcomes in the Americas Network

  A network across the Americas is studying how people living with HIV are cared for, how well they stay in care, and how to prevent other health problems with data from many clinics.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11541272

• HIV Care and Outcomes Across the Americas Network

  A long-running network of doctors and researchers across the Americas examines how people living with HIV are cared for, how outcomes differ, and what could improve treatment and health in real-world settings.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11541271

• HIV research network across the Americas improving care, outcomes, and prevention

  A large international network collaborates to understand and improve HIV care and health outcomes in the Americas, using large databases and partnerships with clinics.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11541270

• HIV care and outcomes in the Americas network

  A regional HIV research network in the Americas studies how people living with HIV access care, stay in care, and how health issues like tuberculosis, mental health, and non-communicable diseases affect them.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11541269

• HIV care and outcomes across the Americas network

  A network-led effort across several countries to improve understanding and care of people living with HIV through shared data, mentorship, and collaborative studies.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11541268

• HIV care and outcomes in the Americas: CCASAnet network study

  A research effort in the Americas is studying how people living with HIV receive care and how well treatments work across several countries.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11541267

• CCASAnet: HIV care and outcomes across the Americas

  A large network across the Americas studies how HIV care and health outcomes look in real-world settings to improve care for people living with HIV.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11541266

• HIV care and outcomes across the Americas network

  A regional network is studying how people living with HIV are doing across many countries in the Americas to improve care and outcomes.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11541265

• HIV care and outcomes across the Americas network

  A patient-focused program to better understand how HIV care is delivered and what helps people stay healthy across the Americas.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11541262

• Center for Undiagnosed Diseases using AI and big data

  A Vanderbilt-led initiative uses AI and data science to help people with mysterious medical conditions get clearer diagnoses and better care.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11538401

• Big-data approach to curb HIV, hepatitis C, and opioid problems in the South

  A large data project uses health information from southern communities to reduce HIV, hepatitis C, and opioid-related harm.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11537599

• Maternal and Pediatric Precision Therapeutics Center at Vanderbilt (VICE-MPRINT)

  A Vanderbilt-led center aims to improve personalized medicines for pregnant people and children by using health data and new tools to study how genes affect drug responses and neonatal opioid withdrawal.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11536362

• Breast Cancer Diagnostic Kit to Improve Early Diagnosis in Uganda

  A new, easy-to-use breast cancer diagnostic kit is being tested in Uganda to help doctors find cancer earlier in primary care clinics.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11535337

Quick answers

How many clinical trials run by Vanderbilt University Medical Center are recruiting right now?

116, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (114 trials), Nigeria (1 trial), South Africa (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 12, Phase 4: 8, Early Phase 1: 7, Phase 1: 4. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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