Cyclic vs Static Manual Aspiration for Acute Large Vessel Occlusion Stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, prospective randomized trial compares two manual aspiration techniques using FDA-approved devices to treat acute ischemic stroke due to large vessel occlusion. Participants with occlusions in the terminal ICA or M1 MCA and within 24 hours of symptom onset will be assigned 1:1 to either the cyclic plunger technique or static suction. The primary outcome is first pass effect, defined as achieving a TICI 2c/3 after the first attempt, with secondary outcomes including overall recanalization, 90-day functional status, catheter navigation success, and procedural efficiency. Approximately 500 participants across 20 sites are planned, with Vanderbilt University Medical Center as the lead site and Vanderbilt as the sponsor.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- Acute ischemic stroke due to occlusion of the terminal ICA or M1 segment of the MCA, Treatment can be initiated within 24 hours of symptom onset, Age 18 years or older

Exclusion Criteria:

* Evidence of acute intracranial hemorrhage prior to treatment, Failure to obtain informed consent

Where it's running

• Vanderbilt University Medical Center
  Nashville, Tennessee, United States Recruiting

Study contacts

• Study coordinator: Michael T Froehler
• Email: m.froehler@vumc.org
• Phone: 6154210300

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.