Identifying biomarkers in tissue and fluid samples from colorectal cancer patients
Novel Colon Cancer Markers in Gastrointestinal Tissue and Biofluids
Vanderbilt University Medical Center · NCT00899626
This study is trying to find new markers in tissue and fluid samples from people with colorectal cancer and healthy volunteers to see if they can help identify cancer risk and improve screening methods.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 5000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Vanderbilt University Medical Center (other) |
| Locations | 2 sites (Nashville, Tennessee and 1 other locations) |
| Trial ID | NCT00899626 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify new potential biomarkers associated with gastrointestinal cancers by analyzing tissue and biological fluid samples from patients undergoing colonoscopy, endoscopy, or surgery. Participants include both cancer patients and healthy volunteers, with samples collected for proteomic analysis to discover substances that may indicate cancer risk. The study also seeks to develop new screening strategies based on these biomarkers. Participants will be followed for up to five years to assess the prognostic significance of identified biomarkers.
Who should consider this trial
Good fit: Ideal candidates include individuals undergoing colonoscopy or endoscopy for diagnostic or screening purposes who have a diagnosis of gastrointestinal cancer, polyps, or inflammatory bowel disease.
Not a fit: Patients who do not require colonoscopy or endoscopy and do not have a history of gastrointestinal issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved screening and early detection strategies for gastrointestinal cancers.
How similar studies have performed: Other studies have shown promise in identifying biomarkers for cancer detection, suggesting that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
DISEASE CHARACTERISTICS: * Undergoing colonoscopy or endoscopy for diagnostic or screening purposes at the Vanderbilt University Medical Center or at the Veterans Affairs Medical Center AND * Meets 1 of the following criteria: * Diagnosis of gastrointestinal (GI) cancer, polyps, or inflammatory bowel disease * History of previously treated GI cancer, polyps, or inflammatory bowel disease PATIENT CHARACTERISTICS: * Capable of giving informed consent * Not mentally or medically impaired * No bleeding disorder PRIOR CONCURRENT THERAPY: * See Disease Characteristics
Where this trial is running
Nashville, Tennessee and 1 other locations
- Veterans Affairs Medical Center - Nashville — Nashville, Tennessee, United States (RECRUITING)
- Vanderbilt-Ingram Cancer Center — Nashville, Tennessee, United States (RECRUITING)
Study contacts
- Study coordinator: Kristen K Ciombor, MD
- Email: kristen.k.ciombor@vumc.org
- Phone: 6159368422
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Colorectal Cancer, Esophageal Cancer, Gastric Cancer, Pancreatic Cancer, Precancerous Condition, colon cancer, gastric cancer, pancreatic cancer