Assessing cardiovascular health after preeclampsia
Official title: Identification of Early HFpEF After Preeclampsia by Exercise Stress Testing
Run by Vanderbilt University Medical Center · NCT06741436 · Data updated 2026-11-12
This study looks at the heart health of women who had preeclampsia during pregnancy to see if it affects their cardiovascular risks later on.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 500 (estimated) |
| Sponsor | Vanderbilt University Medical Center Academic / other |
| Locations | 1 site (Nashville, Tennessee) |
| Status | Recruiting |
| Started | February 18, 2025 |
| Main results expected | June 30, 2029 |
| Study ends | June 30, 2029 |
| Registry record updated | April 14, 2026 |
| Trial ID | NCT06741436 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women over 18 years old who have given birth at Vanderbilt University Medical Center and have been diagnosed with preeclampsia.
✕Probably not a fit
Patients who are under 18, unable to provide informed consent, or have significant pre-existing cardiovascular conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the cardiovascular health of women who have experienced preeclampsia during pregnancy. Participants will be identified through electronic health records and will include both women diagnosed with preeclampsia and a control group without the condition. The study will focus on understanding the long-term cardiovascular risks associated with preeclampsia, particularly in relation to endothelial dysfunction and heart health. Recruitment will occur during the third trimester and at the time of labor and delivery, with a target enrollment of 250 cases and 250 controls.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of cardiovascular risks in women post-preeclampsia.
How similar studies have gone: While studies on cardiovascular health post-preeclampsia are emerging, this specific approach focusing on endothelial dysfunction and long-term outcomes is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Women age \> 18 years 2. Give birth at VUMC 3. Have a diagnosis of PreE based on accepted American College of Obstetricians and Gynecologists criteria Exclusion Criteria: 1. Age \<18 years old 2. Unable to provide informed consent 3. Does not speak English 4. Active COVID-19 infection 5. Residual symptoms related to prior COVID-19 infection 6. HIV infection 7. Hepatitis B or C infection 8. Pulmonary arterial hypertension 9. Sickle cell disease 10. Pulmonary embolism 11. Pre-existing cardiomyopathy 12. Coronary artery disease 13. Active substance abuse (other than tobacco or marijuana) 14. Unable to attend postpartum visits Controls 1\. Enrolling controls who meet the same inclusion/exclusion criteria, except they do not have preeclampsia and do not have pre-existing diabetes or chronic hypertension.
Where it's running
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Vanderbilt University Medical Center
Nashville, Tennessee, United States Recruiting
Study contacts
- Principal investigator: Kathryn Lindley, MD, FACC — Vumc
- Study coordinator: Olivia H Patridge, BS
- Email: olivia.h.patridge@vumc.org
- Phone: 615-875-2942
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.