Examining the effects of stress on adults with Tourette Syndrome
Official title: Longitudinal Impact of Stressors in Adults With Tourette Syndrome
Run by Vanderbilt University Medical Center · NCT04851678 · Data updated 2026-11-12
This study looks at how stress affects adults with Tourette Syndrome over two years to see if it changes their tics, mental health, and overall quality of life.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 140 (estimated) |
| Sponsor | Vanderbilt University Medical Center Academic / other |
| Locations | 1 site (Nashville, Tennessee) |
| Status | Recruiting |
| Started | September 30, 2021 |
| Main results expected | March 1, 2027 |
| Study ends | June 30, 2027 |
| Registry record updated | May 5, 2026 |
| Trial ID | NCT04851678 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 who have been diagnosed with Tourette Syndrome or related tic disorders.
✕Probably not a fit
Patients with significant medical, neurologic, or psychiatric conditions other than Tourette Syndrome may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the long-term impact of environmental stressors on adults with Tourette Syndrome (TS) over a two-year period. It will assess how lifetime exposure to stress affects tic severity, psychiatric comorbidities, and overall health-related quality of life. The study will include adults over 18 who meet the diagnostic criteria for TS or related disorders, and it will gather data through interviews and assessments without any interventions. The findings could provide valuable insights into the challenges faced by adults with TS and inform future treatment approaches.
Why it matters
Potential benefit: If successful, this study could enhance understanding of how stress influences the lives of adults with Tourette Syndrome, potentially leading to improved support and interventions.
How similar studies have gone: While there is limited research specifically on the impact of stress in adults with Tourette Syndrome, studies on stress and its effects on mental health have shown promising results.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * adults (\>18) meeting Diagnostic and Statistics Manual, 5th edition (DSM-V) criteria for Tourette syndrome, chronic motor tic disorder, or chronic vocal tic disorder * ability to provide informed consent * English proficiency Exclusion Criteria: \- significant medical, neurologic, or psychiatric diagnoses (e.g. uncontrolled epilepsy, chronic heart failure, schizophrenia) besides TS and its commonly co-occurring psychiatric diagnoses
Where it's running
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Vanderbilt University Medical Center
Nashville, Tennessee, United States Recruiting
Study contacts
- Principal investigator: David A Isaacs, MD, MPH — Vanderbilt University Medical Center
- Study coordinator: Michelle Eckland, BS
- Email: michelle.r.eckland.1@vumc.org
- Phone: 615-875-7394
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.