Clinical trial Recruiting at 1 site Observational Ages 18 and up

Examining the effects of stress on adults with Tourette Syndrome

Official title: Longitudinal Impact of Stressors in Adults With Tourette Syndrome

Run by Vanderbilt University Medical Center · NCT04851678 · Data updated 2026-11-12

This study looks at how stress affects adults with Tourette Syndrome over two years to see if it changes their tics, mental health, and overall quality of life.

More Tourette Syndrome trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment140 (estimated)
SponsorVanderbilt University Medical Center
Academic / other
Locations1 site (Nashville, Tennessee)
StatusRecruiting
StartedSeptember 30, 2021
Main results expectedMarch 1, 2027
Study endsJune 30, 2027
Registry record updatedMay 5, 2026
Trial IDNCT04851678 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults over 18 who have been diagnosed with Tourette Syndrome or related tic disorders.

Probably not a fit

Patients with significant medical, neurologic, or psychiatric conditions other than Tourette Syndrome may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the long-term impact of environmental stressors on adults with Tourette Syndrome (TS) over a two-year period. It will assess how lifetime exposure to stress affects tic severity, psychiatric comorbidities, and overall health-related quality of life. The study will include adults over 18 who meet the diagnostic criteria for TS or related disorders, and it will gather data through interviews and assessments without any interventions. The findings could provide valuable insights into the challenges faced by adults with TS and inform future treatment approaches.

Why it matters

Potential benefit: If successful, this study could enhance understanding of how stress influences the lives of adults with Tourette Syndrome, potentially leading to improved support and interventions.

How similar studies have gone: While there is limited research specifically on the impact of stress in adults with Tourette Syndrome, studies on stress and its effects on mental health have shown promising results.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* adults (\>18) meeting Diagnostic and Statistics Manual, 5th edition (DSM-V) criteria for Tourette syndrome, chronic motor tic disorder, or chronic vocal tic disorder
* ability to provide informed consent
* English proficiency

Exclusion Criteria:

\- significant medical, neurologic, or psychiatric diagnoses (e.g. uncontrolled epilepsy, chronic heart failure, schizophrenia) besides TS and its commonly co-occurring psychiatric diagnoses

Where it's running

  • Vanderbilt University Medical Center
    Nashville, Tennessee, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.