Understanding brain activity in psychiatric disorders
Neural Correlates of Neuropsychiatric Functions
This study is trying to see how brain activity relates to psychiatric and memory disorders in people with epilepsy to help improve diagnosis and treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Vanderbilt University Medical Center Academic / other |
| Locations | 1 site (Nashville, Tennessee) |
| Trial ID | NCT04725409 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the neural activity associated with psychiatric and memory disorders by collecting resting state local field potential recordings from patients with medically refractory epilepsy. Participants will have depth electrodes implanted for seizure localization, and their neural activity will be correlated with psychiatric symptoms assessed through questionnaires. Additionally, subjects may engage in neurocognitive tasks and receive neural stimulation during recordings. The goal is to enhance understanding of disordered neural activity, potentially leading to improved diagnostic and treatment methods for neuropsychiatric conditions.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are undergoing SEEG monitoring at Vanderbilt University Medical Center.
Not a fit: Patients under 18 years of age or those unable to complete questionnaires may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to novel diagnostic and treatment approaches for patients with psychiatric disorders.
How similar studies have performed: While this approach is innovative, similar studies exploring neural correlates of psychiatric disorders have shown promise in understanding brain activity.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Undergoing SEEG monitoring at Vanderbilt University Medical Center * At least 18 years of age * English speaking Exclusion Criteria: * Age \<18 * Not able to complete questionnaires (e.g., unable to comprehend instructions or follow directions)
Where this trial is running
Nashville, Tennessee
- Vanderbilt University Medical Center — Nashville, Tennessee, United States (Recruiting)
Study contacts
- Principal investigator: Sarah Bick, MD — Vanderbilt University Medical Center
- Study coordinator: Isabel Long, BS
- Email: Isabel.Long@vumc.org
- Phone: 615-421-3046
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.