Clinical trial Recruiting at 1 site Observational Ages 18 and up

Understanding brain activity in psychiatric disorders

Official title: Neural Correlates of Neuropsychiatric Functions

Run by Vanderbilt University Medical Center · NCT04725409 · Data updated 2026-11-12

This study is trying to see how brain activity relates to psychiatric and memory disorders in people with epilepsy to help improve diagnosis and treatment options.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorVanderbilt University Medical Center
Academic / other
Locations1 site (Nashville, Tennessee)
StatusRecruiting
StartedMarch 31, 2021
Main results expectedDecember 2027
Study endsDecember 2027
Registry record updatedJune 12, 2026
Trial IDNCT04725409 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older who are undergoing SEEG monitoring at Vanderbilt University Medical Center.

Probably not a fit

Patients under 18 years of age or those unable to complete questionnaires may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the neural activity associated with psychiatric and memory disorders by collecting resting state local field potential recordings from patients with medically refractory epilepsy. Participants will have depth electrodes implanted for seizure localization, and their neural activity will be correlated with psychiatric symptoms assessed through questionnaires. Additionally, subjects may engage in neurocognitive tasks and receive neural stimulation during recordings. The goal is to enhance understanding of disordered neural activity, potentially leading to improved diagnostic and treatment methods for neuropsychiatric conditions.

Why it matters

Potential benefit: If successful, this study could lead to novel diagnostic and treatment approaches for patients with psychiatric disorders.

How similar studies have gone: While this approach is innovative, similar studies exploring neural correlates of psychiatric disorders have shown promise in understanding brain activity.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Undergoing SEEG monitoring at Vanderbilt University Medical Center
* At least 18 years of age
* English speaking

Exclusion Criteria:

* Age \<18
* Not able to complete questionnaires (e.g., unable to comprehend instructions or follow directions)

Where it's running

  • Vanderbilt University Medical Center
    Nashville, Tennessee, United States
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.