Storing deceased donor kidneys at 10°C instead of on ice (4°C)
Official title: Deceased Donor Kidney Storage at 10 Celsius Versus Conventional Storage
Run by Vanderbilt University Medical Center · NCT07385651 · Data updated 2026-11-12
This trial will try to see if deceased donor kidneys stored at 10°C help adult transplant recipients have better kidney function after transplant compared with kidneys stored on ice (4°C).
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Vanderbilt University Medical Center Academic / other |
| Locations | 1 site (Nashville, Tennessee) |
| Status | Recruiting |
| Started | November 18, 2024 |
| Main results expected | June 1, 2027 |
| Study ends | December 2027 |
| Registry record updated | April 6, 2026 |
| Trial ID | NCT07385651 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adult (≥18) single-organ kidney transplant candidates listed at Vanderbilt University Medical Center who consent to receive a deceased donor kidney stored at 10°C are eligible.
✕Probably not a fit
Children under 18, candidates listed for multi-organ transplants, patients who decline consent, and recipients of living-donor kidneys are not eligible and would not be expected to benefit from this specific storage approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will compare outcomes in adults listed for single-organ kidney transplant at Vanderbilt who receive deceased donor kidneys stored at 10°C using the Traferox XPort device versus conventional storage on ice at 4°C. Participants who consent will receive an allocated kidney and have urine collected 24 hours after surgery for biomarker analysis related to ischemia-reperfusion injury and graft function. The trial is motivated by preclinical data showing reduced mitochondrial injury and reactive oxygen species at milder cold temperatures and aims to measure clinical graft function, including rates of delayed graft function. Outcomes will inform whether a change in storage temperature can improve early post-transplant recovery.
Why it matters
Potential benefit: If successful, 10°C storage could reduce delayed graft function and improve short- and long-term graft outcomes for deceased donor kidney recipients.
How similar studies have gone: Preclinical porcine and other organ studies (including lungs) have shown reduced cell injury and markers of mitochondrial damage with 10°C storage, but clinical data in human kidney transplantation remain limited and novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Participant inclusion criteria 1\. All adult single organ kidney transplant candidates on the waiting list at Vanderbilt University Medical Center (VUMC) will be eligible for enrollment. Participant exclusion criteria 1. Kidney transplant candidates less than 18 years old 2. Kidney transplant candidates that decline consent 3. Transplant candidates listed for multi-organ transplant Deceased donor organ inclusion criteria: 1. Donation after brain death or donation after circulatory death kidney donors, whose health care proxy has consented for donation and the possibility of research 2. Deceased donor kidneys that have been allocated to VUMC as a primary match offer prior to organ procurement will be eligible Deceased donor organ exclusion criteria: 1. Donors whose health care proxy has declined consent for the possibility of research 2. Deceased donor kidneys that have been allocated to VUMC as a backup offer 3. Deceased donor kidneys that have been allocated to VUMC as a post procurement offer 4. Deceased donor kidneys that have already been placed on ice
Where it's running
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Vanderbilt University Medical Center
Nashville, Tennessee, United States Recruiting
Study contacts
- Principal investigator: W. Christian Crannell, MD — Vanderbilt University Medical Center
- Study coordinator: W. Christian Crannell, MD
- Email: christian.crannell@vumc.org
- Phone: 615-322-5000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.