Personalized oxygen therapy for critically ill adults
Official title: Personalized oxygen therapy for critically ill adults: a randomized trial
Funded at Vanderbilt University Medical Center · NIH-11579981 · Data updated 2026-11-12
A study tests whether customizing oxygen levels for adults on invasive ventilation can lower death rates and complications.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 15, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $874,123 |
| NIH project number | 4R33HL180352-02 |
| Project ID | NIH-11579981 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+ years) who require invasive mechanical ventilation in an intensive care setting.
✕Less likely to help
Patients not eligible for ICU-level care or those not on mechanical ventilation would not benefit from this trial.
What this research studies
If you or a loved one is critically ill and on a ventilator, this trial aims to find out if choosing different oxygen targets tailored to each patient can improve survival. The study builds on earlier work comparing high and low oxygen targets and uses a personalized model to decide the best target for each person. Researchers will monitor outcomes to see if this individualized approach reduces mortality and other complications compared with standard care. Participation would involve using specific oxygen targets guided by patient data during the ICU stay.
Why it matters
Potential benefit: If successful, patients on mechanical ventilation could have better survival odds through more precise oxygen therapy.
How similar studies have gone: Prior randomized trials showed mixed results for high vs low oxygen targets, with personalized targeting showing promise in secondary analyses.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Semler, Matthew Wall — Vanderbilt University Medical Center
- Study coordinator: Semler, Matthew Wall
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.