Observational study on Alzheimer's disease and cognitive health in older adults
Tennessee Alzheimer's Project
This study is looking for older adults with and without memory problems to help researchers learn more about Alzheimer's disease and improve ways to prevent and treat it.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | Vanderbilt University Medical Center Academic / other |
| Locations | 1 site (Nashville, Tennessee) |
| Trial ID | NCT05372172 on ClinicalTrials.gov |
What this trial studies
The Tennessee Alzheimer's Project aims to create a diverse clinical cohort of up to 1000 participants aged 60 and older, including those with mild cognitive impairment and Alzheimer's disease. This observational study will provide researchers with access to clinical data, biosamples, and neuroimaging data to enhance understanding and treatment of Alzheimer's disease. Participants will undergo annual comprehensive assessments, including blood draws, questionnaires, and neuropsychological evaluations, to support ongoing research efforts in Alzheimer's prevention and treatment. The project is part of the Vanderbilt Alzheimer's Disease Research Center's broader initiative to address the growing public health crisis of Alzheimer's disease.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 60 and older who are cognitively unimpaired, have mild cognitive impairment, or have Alzheimer's disease.
Not a fit: Patients with major psychiatric or neurological illnesses, or those unable to undergo MRI, may not benefit from this study.
Why it matters
Potential benefit: If successful, this project could lead to improved early detection and treatment strategies for Alzheimer's disease.
How similar studies have performed: Other studies have shown success in using similar cohort approaches to enhance Alzheimer's research, making this a promising initiative.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 60 or older * Meet standard criteria for (a) cognitively unimpaired, (b) mild cognitive impairment, or (c) Alzheimer's disease * English speaking * Individuals who lack decisional capacity to provide informed consent at baseline will not be enrolled in the study Exclusion Criteria: * No available reliable study partner (reliable is defined as someone who interacts significantly with the participant and is available to participate in study visits in person or by phone) * History of major psychiatric illness (e.g., schizophrenia, bipolar), neurological illness (e.g., epilepsy, multiple sclerosis, Parkinson's disease), or head injury with significant loss of consciousness. * Unable to undergo MRI (e.g., claustrophobia, ferrous metal in body)
Where this trial is running
Nashville, Tennessee
- Vanderbilt University Medical Center — Nashville, Tennessee, United States (Recruiting)
Study contacts
- Principal investigator: Angela Jefferson, PhD — Professor of Neurology
- Study coordinator: Michelle Houston
- Email: michelle.houston@vumc.org
- Phone: 615-875-3175
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.