Observational study on Alzheimer's disease and cognitive health in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The Tennessee Alzheimer's Project aims to create a diverse clinical cohort of up to 1000 participants aged 60 and older, including those with mild cognitive impairment and Alzheimer's disease. This observational study will provide researchers with access to clinical data, biosamples, and neuroimaging data to enhance understanding and treatment of Alzheimer's disease. Participants will undergo annual comprehensive assessments, including blood draws, questionnaires, and neuropsychological evaluations, to support ongoing research efforts in Alzheimer's prevention and treatment. The project is part of the Vanderbilt Alzheimer's Disease Research Center's broader initiative to address the growing public health crisis of Alzheimer's disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 60 or older
* Meet standard criteria for (a) cognitively unimpaired, (b) mild cognitive impairment, or (c) Alzheimer's disease
* English speaking
* Individuals who lack decisional capacity to provide informed consent at baseline will not be enrolled in the study

Exclusion Criteria:

* No available reliable study partner (reliable is defined as someone who interacts significantly with the participant and is available to participate in study visits in person or by phone)
* History of major psychiatric illness (e.g., schizophrenia, bipolar), neurological illness (e.g., epilepsy, multiple sclerosis, Parkinson's disease), or head injury with significant loss of consciousness.
* Unable to undergo MRI (e.g., claustrophobia, ferrous metal in body)

Where it's running

• Vanderbilt University Medical Center
  Nashville, Tennessee, United States Recruiting

Study contacts

• Principal investigator: Angela Jefferson, PhD — Professor of Neurology
• Study coordinator: Michelle Houston
• Email: michelle.houston@vumc.org
• Phone: 615-875-3175

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.