Predicting the risk of postpartum hemorrhage during childbirth

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research project aims to improve childbirth safety by utilizing advanced computer models to predict the risk of postpartum hemorrhage (PPH). The study compares a traditional risk assessment tool with a new model that evaluates 21 factors and updates in real-time during labor. If a patient's risk exceeds a certain threshold, a Best Practice Advisory (BPA) will alert clinicians to recommended interventions. The goal is to enhance perinatal outcomes by providing timely and evidence-based recommendations for at-risk patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All vaginal and cesarean deliveries occurring at Vanderbilt University Medical Center

Exclusion Criteria:

* All patients will be randomized at the time of admission to the obstetric service. Patients who are discharged prior to delivery will be excluded from subsequent analysis. Any patients with a pre-delivery planned hysterectomy (for placenta increta or percreta) will be excluded from the treatment algorithm and primary analysis.

Where it's running

• Vanderbilt University Medical Center
  Nashville, Tennessee, United States Recruiting

Study contacts

• Principal investigator: Holly Ende, MD — Vanderbilt University Medical Center
• Study coordinator: Holly Ende, MD
• Email: holly.ende@vumc.org
• Phone: 615-322-8476

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Evaluating ultrasound to predict postpartum hemorrhage risk

  This study is testing if ultrasound exams done shortly after delivery can help predict the risk of bleeding complications for new mothers in the hours following childbirth.

  Recruiting Endeavor Health · Evanston, Illinois · NCT06898034

• Comparing carbetocin and oxytocin to prevent postpartum bleeding after cesarean delivery

  This study is testing whether carbetocin works better than oxytocin to prevent heavy bleeding after a cesarean delivery in women who are at higher risk for this complication.

  Recruiting Samuel Lunenfeld Research Institute, Mount Sinai Hospital · Toronto, Ontario · NCT06333340

• Point-of-care hemoglobin testing during pregnancy

  This project will test non-invasive and finger-prick devices to see if they give accurate, immediate hemoglobin readings for pregnant people during prenatal visits.

  Recruiting Inova Health Care Services · Washington D.C., District of Columbia and 1 other locations · NCT05977686

• Investigating how oxytocin works during cesarean deliveries

  This study is testing how oxytocin works during scheduled cesarean deliveries to see if it helps prevent complications like uterine atony in new mothers.

  Recruiting Phase 2 Stanford University · Stanford, California and 1 other locations · NCT05488457

• Using Tranexamic Acid to Prevent Postpartum Hemorrhage

  This study is testing if Tranexamic Acid can help prevent heavy bleeding after childbirth in women having cesarean sections or vaginal deliveries.

  Recruiting at 2 sites Phase 2 Inova Health Care Services · Washington D.C., District of Columbia and 1 other locations · NCT05370820

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.