Collecting tissue samples from head and neck cancer patients and healthy participants
Official title: Head and Neck Tumor Tissue Repository and Clinical Database
Run by Vanderbilt University Medical Center · NCT00898638 · Data updated 2026-11-12
This study is collecting tissue, saliva, and blood samples from people with head and neck cancer and healthy individuals to help researchers learn more about the disease and improve treatment in the future.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 8000 (estimated) |
| Sponsor | Vanderbilt University Medical Center Academic / other |
| Locations | 4 sites (Nashville, Tennessee and 3 other locations) |
| Status | Recruiting |
| Started | February 13, 2003 |
| Main results expected | December 2050 |
| Study ends | December 2050 |
| Registry record updated | October 28, 2025 |
| Trial ID | NCT00898638 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients diagnosed with head and neck cancer or those being treated at Vanderbilt University Medical Center, as well as healthy participants.
✕Probably not a fit
Patients with conditions unrelated to head and neck cancer or those not meeting the eligibility criteria may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This research collects and stores tissue, saliva, and blood samples from patients diagnosed with head and neck cancer as well as healthy participants. The objective is to maintain a clinical database related to diagnosis and treatment outcomes while developing a repository of biospecimens for future cancer studies. Patients undergoing surgery or bronchoscopy will provide tumor samples, and additional samples will be collected periodically. Healthy participants will contribute samples at baseline only, and comprehensive medical histories will also be gathered.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of head and neck cancer and improve future diagnostic and treatment strategies.
How similar studies have gone: Other studies have successfully utilized similar biospecimen collection methods to advance cancer research, indicating a promising approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
DISEASE CHARACTERISTICS: * Meets 1 of the following criteria: * Diagnosis of head and neck cancer * Being treated at Vanderbilt University Medical Center for the cancer * Healthy participant PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified
Where it's running
-
Vanderbilt-Ingram Cancer Center - Cool Springs
Nashville, Tennessee, United States Recruiting -
Vanderbilt-Ingram Cancer Center at Franklin
Nashville, Tennessee, United States Recruiting -
Veterans Affairs Medical Center - Nashville
Nashville, Tennessee, United States Recruiting -
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States Recruiting
Study contacts
- Principal investigator: Eben Rosenthal, MD — Vanderbilt University Medical Center
- Study coordinator: Brandee Brown
- Email: brandee.t.brown@vumc.org
- Phone: 615-936-4896
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Phenotype-based Pain Guidance for Head and Neck Cancer-Related Pain (pilot)
This pilot test sees if tailoring pain treatment to a patient’s pain type can reduce head and neck cancer pain in adults who haven’t started cancer treatment yet.
-
Airway ultrasound in head and neck cancer patients
This observational study tests whether neck ultrasound measurements of the airway match CT measurements in adults with maxillofacial cancer undergoing surgery with anesthesia.
-
Safe use of metformin and naproxen to help prevent cancer in people with Fanconi anemia
This study tests whether metformin and naproxen can lower the chance of cancer developing in adults with Fanconi anemia.
-
Iparomlimab and Tuvonralimab With Cetuximab Before Surgery in Resectable Oral Cancer
In this phase 2 study, patients with locally advanced, resectable oral squamous cell carcinoma will receive a combination of iparomlimab, tuvonralimab, and cetuximab before surgery to see if the treatment is safe and can shrink tumors.
-
SumMET: Targeted radioligand therapy for c-MET–positive solid tumors
This first‑in‑human study tests the safety and potential effectiveness of a radioligand therapy called [225Ac]Ac-FL-261 in adults with advanced or metastatic solid tumors that overexpress c-MET.
-
Using Silverlon for head and neck patients with tracheostomies
This early-phase study tests whether Silverlon dressings can prevent severe skin reactions under tracheostomy collars in adults with head and neck cancer.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.