Clinical trial Recruiting at 4 sites Observational Ages 18 and up

Collecting tissue samples from head and neck cancer patients and healthy participants

Official title: Head and Neck Tumor Tissue Repository and Clinical Database

Run by Vanderbilt University Medical Center · NCT00898638 · Data updated 2026-11-12

This study is collecting tissue, saliva, and blood samples from people with head and neck cancer and healthy individuals to help researchers learn more about the disease and improve treatment in the future.

More Head and Neck Cancer trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment8000 (estimated)
SponsorVanderbilt University Medical Center
Academic / other
Locations4 sites (Nashville, Tennessee and 3 other locations)
StatusRecruiting
StartedFebruary 13, 2003
Main results expectedDecember 2050
Study endsDecember 2050
Registry record updatedOctober 28, 2025
Trial IDNCT00898638 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients diagnosed with head and neck cancer or those being treated at Vanderbilt University Medical Center, as well as healthy participants.

Probably not a fit

Patients with conditions unrelated to head and neck cancer or those not meeting the eligibility criteria may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research collects and stores tissue, saliva, and blood samples from patients diagnosed with head and neck cancer as well as healthy participants. The objective is to maintain a clinical database related to diagnosis and treatment outcomes while developing a repository of biospecimens for future cancer studies. Patients undergoing surgery or bronchoscopy will provide tumor samples, and additional samples will be collected periodically. Healthy participants will contribute samples at baseline only, and comprehensive medical histories will also be gathered.

Why it matters

Potential benefit: If successful, this study could enhance our understanding of head and neck cancer and improve future diagnostic and treatment strategies.

How similar studies have gone: Other studies have successfully utilized similar biospecimen collection methods to advance cancer research, indicating a promising approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
DISEASE CHARACTERISTICS:

* Meets 1 of the following criteria:

  * Diagnosis of head and neck cancer
  * Being treated at Vanderbilt University Medical Center for the cancer
  * Healthy participant

PATIENT CHARACTERISTICS:

* Not specified

PRIOR CONCURRENT THERAPY:

* Not specified

Where it's running

  • Vanderbilt-Ingram Cancer Center - Cool Springs
    Nashville, Tennessee, United States
    Recruiting
  • Vanderbilt-Ingram Cancer Center at Franklin
    Nashville, Tennessee, United States
    Recruiting
  • Veterans Affairs Medical Center - Nashville
    Nashville, Tennessee, United States
    Recruiting
  • Vanderbilt-Ingram Cancer Center
    Nashville, Tennessee, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Phenotype-based Pain Guidance for Head and Neck Cancer-Related Pain (pilot)

    This pilot test sees if tailoring pain treatment to a patient’s pain type can reduce head and neck cancer pain in adults who haven’t started cancer treatment yet.

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  • Airway ultrasound in head and neck cancer patients

    This observational study tests whether neck ultrasound measurements of the airway match CT measurements in adults with maxillofacial cancer undergoing surgery with anesthesia.

    Recruiting at 2 sites University Hospital Dubrava · Zagreb, City of Zagreb and 1 other locations · NCT07910149

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    This study tests whether metformin and naproxen can lower the chance of cancer developing in adults with Fanconi anemia.

    Recruiting at 2 sites Phase 1 Rockefeller University · Minneapolis, Minnesota and 1 other locations · NCT07901959

  • Iparomlimab and Tuvonralimab With Cetuximab Before Surgery in Resectable Oral Cancer

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    Recruiting Phase 2 Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Shanghai, Shanghai Municipality · NCT07882888

  • SumMET: Targeted radioligand therapy for c-MET–positive solid tumors

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    Recruiting at 2 sites Phase 1/2 Full-Life Technologies UK Limited · Minneapolis, Minnesota and 1 other locations · NCT07873450

  • Using Silverlon for head and neck patients with tracheostomies

    This early-phase study tests whether Silverlon dressings can prevent severe skin reactions under tracheostomy collars in adults with head and neck cancer.

    Recruiting Phase 1 State University of New York - Upstate Medical University · Syracuse, New York · NCT07856732

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.