NIH-funded research U01 cooperative agreement

HIV care and outcomes in the Americas network

Official title: Caribbean, Central, and South America network for HIV Epidemiology (CCASAnet)

Funded at Vanderbilt University Medical Center · NIH-11541269 · Data updated 2026-11-12

A regional HIV research network in the Americas studies how people living with HIV access care, stay in care, and how health issues like tuberculosis, mental health, and non-communicable diseases affect them.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionVanderbilt University Medical Center
NIH-funded
Lab location1 site (Nashville, United States)
Project startJune 15, 2006
Project endMay 31, 2028
Funding year2026
Award (this year)$123,962
NIH project number3U01AI069923-22S6
Project IDNIH-11541269 on NIH RePORTER

Who could benefit from this research

Could help

People living with HIV across Argentina, Brazil, Chile, Haiti, Honduras, Mexico, Peru, and the United States, including pregnant women, adolescents, and older adults.

Less likely to help

Care improvements may be limited for populations not represented in the study sites or in settings with very different health systems.

What this research studies

This project is a long-running, collaborative effort that collects and harmonizes HIV care data from sites across the Americas. Researchers analyze patient care, outcomes, and related health conditions to improve understanding of the HIV care continuum. The team also focuses on building biostatistics and informatics methods and mentoring researchers at partner sites. Over time, they plan to examine care gaps, pregnancy-related outcomes, substance use, and mental health among diverse populations, including adolescents and older adults. The work is embedded in real-world clinical data to inform better strategies for treatment and prevention.

Why it matters

Potential benefit: If successful, findings could inform policies and practices that improve HIV care, retention, and health outcomes for people across the Americas.

How similar studies have gone: Observational HIV research collaborations like leDEA have yielded important insights into care continua and outcomes, supporting the value of this network.

Where this research is happening

  • Vanderbilt University Medical Center
    Nashville, United States
    Active

Researchers

  • Principal investigator: Castilho, Jessica L — Vanderbilt University Medical Center
  • Study coordinator: Castilho, Jessica L

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.