Neural basis of working memory in people with memory disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study records neural activity associated with working memory using depth electrodes implanted for clinical seizure monitoring. It analyzes local field potentials and single neuron spikes during neurocognitive tasks, with some sessions including brain stimulation via depth electrodes. The goal is to better understand how memory works in health and memory disorders and to explore potential diagnostic and treatment avenues, including stimulation. The research is conducted at Vanderbilt University Medical Center with collaboration from the NIMH. Participants are adults undergoing SEEG monitoring, able to complete tasks and English-speaking.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Undergoing SEEG monitoring at Vanderbilt University Medical Center
* Age \>18
* English speaking

Exclusion Criteria:

* Age \<18
* Not able to complete questionnaires (unable to comprehend instructions or follow directions)

Where it's running

• Vanderbilt University Medical Center
  Nashville, Tennessee, United States Recruiting

Study contacts

• Study coordinator: Lucas Chang, BS
• Email: lucas.m.chang@vumc.org
• Phone: 615-421-3046

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Spatial scene memory testing for people with temporal lobe epilepsy having surgery

  This project tests whether a virtual tour memory task combined with brain recordings can show how adults with temporal lobe epilepsy recognize and recall places.

  Recruiting at 2 sites University of California, Davis · Sacramento, California and 1 other locations · NCT07580183

• Eye scan to detect Alzheimer’s related protein deposits in adults with memory issues

  A screening eye test is being tried in adults with memory problems to see if retinal changes can signal Alzheimer’s-related protein deposits.

  Recruiting at 2 sites Eli Lilly and Company · Abu Dhabi and 2 other locations · NCT07254234

• HOBSCOTCH-MS: Home-based telehealth cognitive coaching for people with multiple sclerosis

  This program will test whether a home-based telehealth cognitive coaching program (HOBSCOTCH-MS) can improve thinking, memory, and quality of life for people with MS and reduce caregiver burden.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT06951919

• Home-based self-management and cognitive training for brain tumor survivors

  This trial will try a home-based cognitive coaching program to see if it improves thinking and quality of life for adults who survived non-glioblastoma brain tumors, with optional caregiver participation.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT06930846

• Nutrition-based interventions to prevent cognitive decline

  This study is testing if a 6-month nutrition program can help adults at higher risk for dementia keep their thinking skills sharp.

  Recruiting at 2 sites Instituto de Saude Publica da Universidade do Porto · Porto, Portugal and 1 other locations · NCT06853405

• Investigating biomarkers related to Alzheimer's disease and cognitive impairment

  This study is trying to see how blood tests and brain scans relate to Alzheimer's disease and memory issues in older adults aged 60 to 90.

  Recruiting at 23 sites GAP Innovations, PBC · Atlantis, Florida and 25 other locations · NCT06584357

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.