Guided electronic tools to help clinicians manage MASLD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pragmatic randomized trial at Vanderbilt sites will compare usual care to using the eMPOWER decision aid embedded in the electronic health record. Providers receive patient-specific recommendations for MASLD care based on clinical features and risk factors, with primary and secondary outcomes focused on care linkage and noninvasive fibrosis testing. Participants are adults with MASLD or related liver conditions followed for 12 months after a 3-year study period. Primary endpoint is referral linkage to hepatology; secondary endpoints include fibrosis assessment completion, referral completion, and time to elastography or referrals. Qualitative surveys and interviews with clinicians will assess acceptance and barriers to use.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (age ≥ 18 years)
* Outpatient clinic visit (in-person or telemedicine) at a participating clinic site
* Demonstrated Screening Need due to High Risk Profile, which includes the following: Diagnostic Codes for MASLD or Hepatic Steatosis on Imaging PLUS at least one cardiometabolic risk factors; OR Chronically Elevated Liver Enzymes (\> 6 months); OR patient with impaired glycemic control (prediabetes/diabetes); OR 2 or more cardiometabolic risk factors present

Exclusion Criteria:

* Solid Organ Transplant Recipient
* Existing Hepatology Relationship Evidenced by Prior Hepatology Visit Within 3 Years
* Active Cancer Diagnoses
* Diagnoses for Alcohol-Related Conditions
* Pregnant Individuals
* Receiving Palliative Care Services

Where it's running

• Vanderbilt University Medical Center
  Nashville, Tennessee, United States Recruiting

Study contacts

• Principal investigator: Ashley Spann, MD, MSACI — Vanderbilt University Medical Center
• Study coordinator: Michael McGill
• Email: michael.g.mcgill@vumc.org
• Phone: 6153224643

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Reset-INSPIRE: See if CGM can reveal insulin sensitivity in people at risk for MASLD

  This study tests whether real-time CGM data can accurately reflect insulin sensitivity in adults without diabetes who are at risk for MASLD.

  Recruiting National University Health System, Singapore · Singapore, Singapore · NCT07861191

• ALN-CIDEB in adults with MASLD to see if it helps the liver

  This study tests whether ALN-CIDEB can help adults with MASLD and its liver damage compared to placebo.

  Recruiting at 4 sites Phase 3 Regeneron Pharmaceuticals · Miami, Florida and 3 other locations · NCT07854782

• Peanut intake and liver health in adults with MASLD

  This study tests whether adding peanuts to daily meals for 12 weeks can improve liver markers and metabolic health in adults with MASLD.

  Recruiting Henry Ford Health System · Detroit, Michigan · NCT07646197

• Liver gene response to IV glucose during bariatric surgery in obese people with and without MASLD.

  This trial will test whether giving sugar through a vein changes liver gene activity during bariatric surgery in people with obesity who do or do not have MASLD.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam, North Holland · NCT07326865

• Low‑methoxy pectin for inflammation, gut microbiome, and metabolic health in MASLD

  This tests whether taking daily low‑methoxy pectin for six weeks can reduce inflammation and improve gut bacteria and metabolic markers in adults with MASLD.

  Recruiting at 3 sites University of Nottingham · Nottingham, United Kingdom and 2 other locations · NCT07093346

• Digital early-warning system to predict acute lung injury after major liver surgery

  This study will try a machine-learning based warning tool to predict early acute lung injury in adults having major liver surgery.

  Recruiting at 4 sites Beijing Tsinghua Chang Gung Hospital · Beijing, Beijing Municipality and 3 other locations · NCT07070362

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.