Investigating blood flow changes in POTS after glucose intake

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore how glucose ingestion affects blood flow and symptoms in patients with Postural Tachycardia Syndrome (POTS). It will compare POTS patients experiencing postprandial symptoms with healthy controls, measuring changes in splanchnic venous capacitance and blood flow before and after consuming a glucose solution. The study employs an innovative technique using segmental impedance to assess these changes during different body positions. The goal is to understand the mechanisms behind worsening symptoms in POTS patients after meals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Between 18 and 50years of age
* Cases: Diagnosis of POTS with presyncope symptoms after meals Or

Controls:

* With no significant past medical history, non-smokers and not on chronic medications.
* Body mass index (BMI) between 18.5 to 29.9 kg/m2
* If pre-menopausal women: must have regular menstrual cycle.

Exclusion Criteria:

* BMI above ≥30 kg/m2
* Irregular menstrual cycle
* Intolerance to CPAP.
* Chronic use of acetaminophen
* Heart problems: myocardial infarction, angina, heart failure, stroke
* Undergone any heart related procedures or stents or on pacemaker.
* Uncontrolled hypertension.
* Type 1 or type 2 diabetes mellitus
* Pregnant or breast-feeding women.
* Impaired liver function
* Impaired Kidney function test.
* Anemia (Hematocrit\<34%).
* Ongoing substance abuse.
* Subjects with abnormal EKG
* History of seizures.
* Diagnosed with neuropathy due to any reason
* History of neck surgery.
* Smoker,
* On statin therapy for high cholesterol
* Rheumatoid arthritis.
* On oral corticosteroids,
* Current infections
* Documented of moderate decrease in blood volume

Where it's running

• Vanderbilt University Medical Center
  Nashville, Tennessee, United States Recruiting

Study contacts

• Principal investigator: Cyndya Shibao, M.D — Vanderbilt University Medical Center
• Study coordinator: Pedro J Ortiz, MD
• Email: pedro.ortiz.saavedra@vumc.org
• Phone: 689-233-2623

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.