Using CPAP to treat high blood pressure in patients with autonomic failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of continuous positive airway pressure (CPAP) in reducing blood pressure in patients suffering from supine hypertension due to autonomic failure. Supine hypertension is a common issue in these patients, complicating their treatment for orthostatic hypotension. The study will apply varying levels of CPAP pressure to assess its acute impact on blood pressure. If successful, CPAP may be used as a nighttime treatment for these patients to manage their blood pressure more effectively.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with autonomic failure and with supine hypertension from all races

Exclusion Criteria:

* All medical students
* Pregnant women
* High-risk patients (e.g. heart failure, symptomatic coronary artery disease, liver impairment, history of stroke or myocardial infarction)
* History of serious allergies or asthma.

Where it's running

• Autonomic Dysfunction Center/ Vanderbilt University Medical Center
  Nashville, Tennessee, United States Recruiting

Study contacts

• Principal investigator: Italo Biaggioni, MD — Vanderbilt University Medical Center
• Study coordinator: Bonnie K Black, RN
• Email: autonomics@vumc.org
• Phone: 615-343-6862

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using CPAP to treat high blood pressure in patients with autonomic failure

  This study tests if using a CPAP machine can help people with autonomic failure lower their nighttime blood pressure when they lie down.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT05489575

• Raising the head of the bed to lower blood pressure in patients with autonomic failure

  This study is testing if raising the head of the bed can help people with autonomic failure lower their high blood pressure while lying down.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT04502225

• Using a CO2 rebreather to improve blood pressure in patients with neurogenic orthostatic hypotension

  This study is testing whether a CO2 rebreather can help people with neurogenic orthostatic hypotension improve their blood pressure and feel better when standing up.

  Recruiting University of Calgary · Calgary, Alberta · NCT05908760

• Using an accelerometer to measure symptoms of neurogenic orthostatic hypotension

  This study is testing if using a device to track how long people with neurogenic orthostatic hypotension can stay upright helps show if their medication works better than a placebo.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT04782830

• Imaging with [18F]F-DOPA in patients with autonomic failure

  This study is testing a special imaging technique to see if it can help identify early signs of neurodegenerative diseases in people with autonomic failure.

  Recruiting Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT04246437

• Heat application for managing high blood pressure in patients with autonomic failure

  This study is testing if using a heating pad on the belly at night can help people with autonomic failure lower their high blood pressure while lying down.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT03042988

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.