Using CPAP to treat high blood pressure in patients with autonomic failure
Treatment of Supine Hypertension in Autonomic Failure With Continuous Positive Airway Pressure
This study tests if using a CPAP machine at night can help lower blood pressure in patients with autonomic failure who have high blood pressure when lying down.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 12 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Vanderbilt University Medical Center Academic / other |
| Locations | 1 site (Nashville, Tennessee) |
| Trial ID | NCT03312556 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of continuous positive airway pressure (CPAP) in reducing blood pressure in patients suffering from supine hypertension due to autonomic failure. Supine hypertension is a common issue in these patients, complicating their treatment for orthostatic hypotension. The study will apply varying levels of CPAP pressure to assess its acute impact on blood pressure. If successful, CPAP may be used as a nighttime treatment for these patients to manage their blood pressure more effectively.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with autonomic failure who experience supine hypertension.
Not a fit: Patients with serious underlying conditions such as heart failure or a history of stroke may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve blood pressure management in patients with autonomic failure and supine hypertension.
How similar studies have performed: While CPAP is commonly used for sleep apnea, its application for treating supine hypertension in autonomic failure is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with autonomic failure and with supine hypertension from all races Exclusion Criteria: * All medical students * Pregnant women * High-risk patients (e.g. heart failure, symptomatic coronary artery disease, liver impairment, history of stroke or myocardial infarction) * History of serious allergies or asthma.
Where this trial is running
Nashville, Tennessee
- Autonomic Dysfunction Center/ Vanderbilt University Medical Center — Nashville, Tennessee, United States (Recruiting)
Study contacts
- Principal investigator: Italo Biaggioni, MD — Vanderbilt University Medical Center
- Study coordinator: Bonnie K Black, RN
- Email: autonomics@vumc.org
- Phone: 615-343-6862
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.