Heat application for managing high blood pressure in patients with autonomic failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effects of applying local heat to the abdomen of patients with autonomic failure and supine hypertension during the night. The aim is to determine if this intervention can reduce nocturnal high blood pressure while lying down. Patients with conditions such as Parkinson's Disease, Multiple System Atrophy, and Pure Autonomic Failure will be included. The study will compare the effects of the heating pad against a sham control to assess efficacy and safety.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male and female patients, between 18-80 yrs., with primary autonomic failure (Parkinson Disease, Multiple System Atrophy, and Pure Autonomic Failure) and supine hypertension. Supine hypertension will be defined as SBP≥150 mmHg.
* Patients able and willing to provide informed consent.

Exclusion Criteria:

* Pregnancy
* Significant cardiac, renal or hepatic illness, or with contraindications to administration of pressor agents or with other factors, which in the investigator's opinion would prevent the subject from completing the protocol including clinically significant abnormalities in clinical, mental or laboratory testing.

Where it's running

• Autonomic Dysfunction Center/ Vanderbilt University Medical Center
  Nashville, Tennessee, United States Recruiting

Study contacts

• Principal investigator: Italo Biaggioni, MD — Vanderbilt University Medical Center
• Study coordinator: Bonnie K Black, RN
• Email: autonomics@vumc.org
• Phone: 615-343-6862

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.