Using artificial tears to prevent tear duct blockage after thyroid cancer treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effect of artificial tears on preventing nasolacrimal duct obstruction in patients who have undergone radioactive iodine therapy for thyroid cancer. It is based on previous findings that suggest radioactive iodine can accumulate in the lacrimal system, leading to inflammation and blockage. By administering artificial tears, the study aims to reduce the incidence of this obstruction over a two-year period following treatment. Participants will be monitored for changes in their tear duct function and overall eye health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Radio-iodine therapy for thyroid cancer
2. Radioiodine therapy ≥150 mCi
3. Age 18 or older

Exclusion Criteria:

1. Use of eye drops, other than artificial tears
2. History of periocular trauma with tear duct involvement/lacrimal gland trauma
3. History of lacrimal drainage disease: canaliculitis, dacryocystitis
4. Prior radiotherapy
5. Current or prior use of chemotherapy drugs (i.e. 5-fluorouracil, docetaxel)
6. Medical conditions that predispose to NLD stenosis (i.e. sarcoidosis, granulomatosis with polyangiitis, chronic lymphocytic leukemia)
7. Nasolacrimal duct obstruction at baseline

Where it's running

• Vanderbilt University Medical Center
  Nashville, Tennessee, United States Recruiting

Study contacts

• Study coordinator: Marybeth Carter
• Email: marybeth.l.carter@vumc.org
• Phone: 615-936-1639

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.