Identifying risks of dangerous heart rhythms in genetic heart conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to determine if electrophysiologic mapping and cardiac MRI can identify patients with genetic cardiomyopathies who are at high risk for developing dangerous ventricular arrhythmias. The study will assess the prevalence and mechanisms of inducible ventricular tachycardia, utilize pace-mapping to locate the origins of ventricular arrhythmias, and perform voltage mapping to identify low voltage scar substrates in the heart. Participants will undergo cardiac MRI and voltage mapping as part of the data collection process to enhance understanding of how genetic factors influence arrhythmia risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 and older
* Diagnosed with AF, frequent PVCs, or VT before age 60
* Scheduled for catheter-based AF ablation (de-novo or repeat) OR catheter-based PVC ablation OR catheter-based VT ablation
* Able to provide written, informed consent
* P/LP variant in TTN or other CM gene (cases) or identified as a genotype-negative control.

Exclusion Criteria:

* Diagnosed with a genetic CM or arrhythmia syndrome prior to ablation procedure
* VUS in 'possibly pathogenic' subgroup (control group only)
* Previous PVC or VT ablation
* LVEF \<20%
* Prosthetic mitral or aortic valve
* Contraindication to heparin
* Prior myocardial infarction

Where it's running

• Vanderbilt University Medical Center
  Nashville, Tennessee, United States Recruiting

Study contacts

• Study coordinator: Dakota Graherr, RN
• Email: dakota.grauherr@vumc.org
• Phone: 615-936-6069

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.