Using Tranexamic Acid to Reduce Bleeding in Nasal Reconstruction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effects of tranexamic acid (TXA) administered subcutaneously in patients undergoing nasal Mohs reconstruction with local flaps at Vanderbilt University Medical Center. TXA is an antifibrinolytic agent that helps stabilize the fibrin matrix in the clotting process, potentially reducing postoperative complications such as bleeding, ecchymosis, and hematoma formation. The study is a prospective randomized control trial, comparing TXA treatment to a control group receiving only lidocaine with epinephrine. The goal is to improve surgical outcomes and patient satisfaction following nasal reconstruction.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adults at least 18 years of age undergoing local flap reconstruction (bilobe flap, note flap dorsal nasal flap, advancement flap) of a nasal defect following Mohs micrographic surgery. Reconstructive procedures will be performed by Drs. Yang or Patel in the division of Facial Plastic Surgery in the Department of Otolaryngology, Head and Neck Surgery at Vanderbilt University Medical Center.
2. No other facial plastic procedure or sinus surgery performed simultaneously.
3. Lack of all the below exclusion criteria.

Exclusion Criteria:

1. Known allergy to TXA
2. Intracranial bleeding
3. Known defective color vision
4. History of venous or arterial thromboembolism
5. History of coagulation disorder
6. Active thromboembolic disease
7. Severe renal impairment (diagnosis of chronic kidney disease)
8. History of acute myocardial infarction
9. History of stroke
10. History of seizure
11. History of liver failure
12. Preoperative lab results indicating thrombocytopenia (platelets \<150,000), increased bleeding risk (PT over 45, INR over 1.2).

Where it's running

• Vanderbilt University Medical Center
  Nashville, Tennessee, United States Recruiting

Study contacts

• Principal investigator: Priyesh Patel, MD — Vanderbilt University Medical Center
• Study coordinator: Connie Ma, MD
• Email: connie.ma@vumc.org
• Phone: 2815366877

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.