Assessing how meal timing affects glucose tolerance in young people

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of aligning meal timing and glucose tolerance tests with the natural sleep-wake cycles of young individuals aged 17-23 who have a late or non-late chronotype. Participants will undergo two oral glucose tolerance tests and two standardized meals, with the timing adjusted to match their chronotype, to evaluate differences in glucose tolerance and insulin sensitivity. Continuous glucose monitoring will be utilized to track post-meal glucose levels, and a pilot aim will explore the role of melatonin in glucose metabolism. The study aims to provide insights into how chronotype influences metabolic health in youth.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Overweight similar to (BMI ≥ 85th percentile but \<95th percentile for age and sex per Centers for Disease Control and Prevention growth curves (as Centers for Disease Control and Prevention growth curves contain ages ≤ 20y; if ages 21-23 years, the BMI ≥ 85th and \<95th percentile equivalents for a 20-year-old will be used))
* Post-pubertal
* Normal sleep duration (avg. \>7 hours of sleep per night)
* Social jetlag (difference between weekend and weekday sleep) of \< 2 hours.

Exclusion Criteria:

* Known diabetes, sleep disorders, major organ system illness, pregnancy, or genetic syndrome
* Medication use known to affect insulin sensitivity, glucose tolerance, or circadian rhythm
* Screening high risk for obstructive sleep apnea
* Night shift work.

Where it's running

• Johns Hopkins School of Medicine
  Baltimore, Maryland, United States Recruiting

Study contacts

• Principal investigator: Talia Hitt, MD/MPH/MSHP — Johns Hopkins University
• Study coordinator: Talia Hitt, MD/MPH/MSHP
• Email: thitt2@jhmi.edu
• Phone: 860-324-0072

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.