Fasting blood sugar control in people with and without prediabetes
The regulation of fasting glucose metabolism in people with and without prediabetes
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-11100011
This project looks at how the hormones insulin and glucagon affect fasting blood sugar in adults with and without prediabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11100011 on ClinicalTrials.gov |
What this research studies
I would have blood drawn over time so researchers can measure insulin, glucagon, and glucose and see how those hormones act on fasting blood sugar. The team will test how glucagon changes glucose directly and indirectly through insulin, and how insulin changes glucose directly and indirectly through glucagon. They will use a new method to measure rapid hormone pulse patterns from the pancreas to find early signs of islet cell problems. Comparing people with normal glucose and those with prediabetes aims to pinpoint what changes lead to fasting high blood sugar before full diabetes develops.
Who could benefit from this research
Good fit: Ideal candidates are adults with prediabetes or with normal fasting glucose who can undergo detailed metabolic blood testing at Mayo Clinic Rochester.
Not a fit: Children, people with type 1 diabetes, and those with longstanding or insulin-treated type 2 diabetes are unlikely to be eligible or to benefit from findings focused on early fasting hyperglycemia.
Why it matters
Potential benefit: If successful, this work could reveal early hormone changes that predict or cause fasting high blood sugar and guide new prevention or treatment strategies.
How similar studies have performed: Prior studies show insulin and glucagon interact to control glucose, but using hormone-pulse measurements is a newer approach aimed at detecting earlier islet dysfunction.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VELLA, ADRIAN — MAYO CLINIC ROCHESTER
- Study coordinator: VELLA, ADRIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus