Fasting blood sugar control in people with and without prediabetes
Official title: The regulation of fasting glucose metabolism in people with and without prediabetes
Funded at Mayo Clinic Rochester · NIH-11100011 · Data updated 2026-11-12
This project looks at how the hormones insulin and glucagon affect fasting blood sugar in adults with and without prediabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 1, 2007 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $667,267 |
| NIH project number | 5R01DK078646-19 |
| Project ID | NIH-11100011 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with prediabetes or with normal fasting glucose who can undergo detailed metabolic blood testing at Mayo Clinic Rochester.
✕Less likely to help
Children, people with type 1 diabetes, and those with longstanding or insulin-treated type 2 diabetes are unlikely to be eligible or to benefit from findings focused on early fasting hyperglycemia.
What this research studies
I would have blood drawn over time so researchers can measure insulin, glucagon, and glucose and see how those hormones act on fasting blood sugar. The team will test how glucagon changes glucose directly and indirectly through insulin, and how insulin changes glucose directly and indirectly through glucagon. They will use a new method to measure rapid hormone pulse patterns from the pancreas to find early signs of islet cell problems. Comparing people with normal glucose and those with prediabetes aims to pinpoint what changes lead to fasting high blood sugar before full diabetes develops.
Why it matters
Potential benefit: If successful, this work could reveal early hormone changes that predict or cause fasting high blood sugar and guide new prevention or treatment strategies.
How similar studies have gone: Prior studies show insulin and glucagon interact to control glucose, but using hormone-pulse measurements is a newer approach aimed at detecting earlier islet dysfunction.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Vella, Adrian — Mayo Clinic Rochester
- Study coordinator: Vella, Adrian
Related research
Other NIH-funded projects on the same topics.
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Understanding how fasting glucose is controlled in people with and without prediabetes
This NIH grant studies how insulin and glucagon work together to control fasting glucose in people with and without prediabetes.
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Intermittent fasting with PD-1 inhibitors for non-small cell lung cancer
This grant tests whether a fasting-mimicking diet can boost the effectiveness of PD-1 inhibitors for people with non-small cell lung cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.