Precision medicine for prediabetes: uncovering cardiometabolic subtypes to sharpen risk prediction
Official title: Precision Medicine in Prediabetes: Identifying Cardiometabolic Subtypes to Improve Risk Stratification
Funded at Johns Hopkins University · NIH-11293532 · Data updated 2026-11-12
A Johns Hopkins study will use patient data to find prediabetes subtypes based on cardiometabolic clues and see how these groups differ in progression to diabetes and heart/kidney risks.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 1, 2026 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $116,625 |
| NIH project number | 1R21DK150976-01 |
| Project ID | NIH-11293532 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with prediabetes represented in US cardiovascular and metabolic cohorts.
✕Less likely to help
People without prediabetes or those outside the studied cohorts may not benefit from these findings.
What this research studies
This project analyzes existing cardiovascular and metabolic data from US cohorts to identify distinct prediabetes subtypes using machine learning. By linking these subtypes to outcomes like diabetes, heart disease, kidney disease, and death, researchers aim to improve how we predict who is at higher risk. The goal is to enable more personalized prevention strategies for people with prediabetes. The work is designed to inform which individuals might benefit most from targeted lifestyle changes or therapies.
Why it matters
Potential benefit: If successful, this could lead to better, more personalized prevention plans for people with prediabetes.
How similar studies have gone: Subtyping has shown promise in type 2 diabetes, but this study applies similar methods to prediabetes for the first time.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Rooney, Mary R — Johns Hopkins University
- Study coordinator: Rooney, Mary R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.