Understanding how metabolism and inflammation affect diabetes in teens

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to collect health-related information and blood samples from adolescents to explore the relationship between body composition, lifestyle habits, and diet on meta-inflammatory monocytes (MiMos). The researchers hypothesize that adolescents at risk for metabolic diseases exhibit increased MiMo activity, which may contribute to insulin resistance. By analyzing these factors, the study seeks to provide insights into the mechanisms underlying diabetes and related conditions in this age group.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Between 14 and 18 years of age
* Tanner stage 4 or 5 (mature adult stage of puberty)
* Normal weight (BMI ≥ 5th percentile \& \< 85th percentile), overweight (BMI \> 86th percentile) \& \< 94th percentile), obese weight (BMI percentile ≥ 95th percentile), and/or pre-diabetes (HbA1c \> 5.7%)
* For Type 2 Diabetes cohort, diagnosis of Type 2 Diabetes

Exclusion Criteria:

* Currently pregnant
* Use medications known to affect glucose metabolism (immunosuppressive medications, cancer medications, or high dose steroids), unless prescribed for Type 2 Diabetes management
* Prior diagnosis of autoimmune disease, cancer, or a cognitive or perceptual disability that would inhibit following directions of study staff
* Allergies or intolerance to milk, soy, or palm oil

Where it's running

• University of Michigan
  Ann Arbor, Michigan, United States Recruiting

Study contacts

• Principal investigator: Kanakadurga Singer, MA, MD — University of Michigan
• Study coordinator: The Singer Lab Team
• Email: MiMoStudy@med.umich.edu
• Phone: (734) 615-4938

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.