Using glucose levels to identify early Alzheimer's risk in people with prediabetes.
Glucose Variability as a Digital Biomarker for Preclinical AD Risk in Prediabetes.
This study is looking at how changes in blood sugar levels might help spot early signs of Alzheimer's Disease in older adults who are at risk for Type 2 diabetes, using a special device that tracks glucose levels continuously to see how it relates to thinking and memory.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore County NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10910153 on NIH RePORTER |
What this research studies
This research investigates how fluctuations in glucose levels can serve as a digital biomarker for early signs of Alzheimer's Disease (AD) in older adults who are at risk for Type 2 diabetes. By utilizing Continuous Glucose Monitoring (CGM) technology, the study aims to provide a more detailed understanding of how glucose variability affects cognitive function and the risk of developing AD. Participants will have their glucose levels monitored continuously, allowing researchers to identify patterns that may indicate cognitive decline. The goal is to enhance early detection and intervention strategies for those at risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 21 and above who are at risk for Type 2 diabetes and may be experiencing early cognitive decline.
Not a fit: Patients who do not have prediabetes or are not at risk for Type 2 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better management strategies for Alzheimer's Disease in individuals with prediabetes.
How similar studies have performed: While the use of CGM technology is innovative in this context, previous research has shown success in using digital biomarkers for other conditions, suggesting potential for this approach.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore County — Baltimore, United States (Active)
Researchers
- Principal investigator: Khambaty, Tasneem — University of Maryland Baltimore County
- Study coordinator: Khambaty, Tasneem
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.