Using mirabegron and tadalafil to improve prediabetes treatment
Mirabegron and tadalafil effectiveness for treatment of prediabetes
This study is looking at how well two medications, mirabegron and tadalafil, can help people with prediabetes improve their blood sugar levels and metabolism without needing to lose a lot of weight.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10746813 on NIH RePORTER |
What this research studies
This research investigates the effectiveness of two medications, mirabegron and tadalafil, in treating prediabetes, a condition affecting millions of Americans. The study aims to improve glucose metabolism and insulin sensitivity without requiring significant weight loss. By activating specific pathways in the body, these medications may help convert white fat to beige fat, which is beneficial for glucose management. Participants will be monitored for changes in their glucose tolerance and overall metabolic health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with prediabetes who struggle to make lifestyle changes necessary for reversing their condition.
Not a fit: Patients who are not diagnosed with prediabetes or those who have already developed type 2 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new medication-based approach to prevent the progression of prediabetes to type 2 diabetes.
How similar studies have performed: Previous studies have shown promising results using similar approaches with mirabegron and tadalafil, indicating potential for success in this research.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Kern, Philip a — University of Kentucky
- Study coordinator: Kern, Philip a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.