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Clinical trial Recruiting at 1 site Interventional Ages 25 to 65

Understanding insulin and glucagon interactions during fasting in prediabetes

Official title: Effect of Insulin and Insulin Pulses on Fasting Glucagon Secretion and on Glucose Metabolism in Subjects Without Type 2 Diabetes

Run by Mayo Clinic · NCT06424015 · Data updated 2026-11-12

This study is testing how insulin and glucagon work together to control blood sugar levels during fasting in people with prediabetes.

Quick facts

Study typeInterventional
Ages25 Years to 65 Years
SexAll
Enrollment60 (estimated)
SponsorMayo Clinic
Academic / other
Locations1 site (Rochester, Minnesota)
StatusRecruiting
StartedSeptember 15, 2024
Main results expectedJanuary 1, 2027
Study endsSeptember 1, 2027
Registry record updatedOctober 7, 2026
Trial IDNCT06424015 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals with normal or impaired fasting glucose and normal or impaired glucose tolerance.

Probably not a fit

Patients with HbA1c greater than 6.5%, severe obesity, or those on glucose-lowering medications may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how insulin and glucagon interact to regulate fasting glucose levels in individuals with prediabetes. It aims to explore the effects of insulin signaling on glucagon secretion and how these hormones influence glucose production in the liver. By examining the relationship between insulin and glucagon during fasting, the study seeks to identify potential markers of β-cell health and the dynamics of hormone crosstalk. The interventions include administering intralipid and heparin to assess their impact on hormone secretion.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding and management of fasting glucose levels in prediabetes, potentially preventing the progression to type 2 diabetes.

How similar studies have gone: While there is ongoing research into insulin and glucagon interactions, this specific approach to studying fasting glucose regulation in prediabetes is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* people with normal or impaired fasting glucose and normal or impaired glucose tolerance

Exclusion Criteria:

1. HbA1c \> 6.5%
2. BMI ≥ 35 Kg/M2
3. Use of any glucose-lowering agents including metformin or sulfonylureas.
4. For female subjects: positive pregnancy test at the time of enrollment or study
5. History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
6. Active systemic illness or malignancy.
7. Symptomatic macrovascular or microvascular disease.
8. Hematocrit \< 35%

Where it's running

  • Mayo Clinic in Rochester
    Rochester, Minnesota, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.