Understanding how obesity affects insulin resistance through diet and molecular profiling

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This 12-week intervention focuses on the molecular pathways linking obesity to insulin resistance by employing a controlled diet and weight intervention. Participants will undergo blood, adipose, and stool sampling at three timepoints to monitor changes in cellular processes, alongside direct insulin sensitivity testing and imaging of fat content. The study aims to differentiate between insulin resistant and insulin sensitive individuals with similar obesity profiles, utilizing an integrated omics strategy to uncover the underlying biological mechanisms. By analyzing the effects of various dietary interventions, the research seeks to enhance our understanding of obesity's impact on metabolic health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 35-65
* BMI 25-35 kg/m2
* Stable body weight
* Nondiabetic

Exclusion Criteria:

Patients with;

* diabetes
* major organ disease
* history of liposuction or bariatric surgery
* active eating or psychiatric disorder
* pregnancy or lactation, heavy alcohol use
* recent change in weight (over the past 12 weeks)
* use of weight loss medication, statins, or oral steroids

Clinical screening exclusions;

* hematocrit \< 33%
* fasting glucose \>/= 126 mg/dL
* blood pressure \>160/100 mmHg

Where it's running

• Stanford University
  Stanford, California, United States Recruiting

Study contacts

• Principal investigator: Tracey McLaughlin, MD — Stanford University, Department of Medicine, Division of Endocrinology
• Study coordinator: Ekrem M Ayhan, BS
• Email: ayhane@stanford.edu
• Phone: 908-619-5381

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Endoscopic sleeve gastroplasty for people with obesity and MASH

  This study will test whether endoscopic sleeve gastroplasty plus lifestyle changes helps adults with obesity and MASH lose weight and improve liver health compared with lifestyle changes alone.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06138821

• Understanding how metabolism and inflammation affect diabetes in teens

  This study is trying to see how body weight, lifestyle, and diet affect inflammation and metabolism in teens to better understand diabetes risk.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT06007404

• Collection of human metabolic tissues from obese patients undergoing bariatric surgery

  This study is collecting tissue samples from obese patients having weight loss surgery to see how different metabolic conditions affect type 2 diabetes and obesity.

  Recruiting University Hospital, Montpellier · Montpellier · NCT02861781

• Whole-Body Vibration Training in Women With Obesity With and Without Type 2 Diabetes

  This study tests whether eight weeks of supervised whole-body vibration training changes ankle muscle activity and walking performance in women with obesity, comparing those with and without type 2 diabetes.

  Recruiting Pamukkale University · Denizli · NCT07924436

• EloraTZP for weight loss in adults with overweight/obesity and type 2 diabetes

  This trial tests whether a coformulation of eloralintide and tirzepatide helps people with obesity or overweight and type 2 diabetes lose weight compared with tirzepatide alone.

  Recruiting Phase 3 Eli Lilly and Company · Tucson, Arizona and 74 other locations · NCT07881458

• Clazakizumab for adults with high hsCRP at risk for a heart event

  This study tests whether clazakizumab can lower inflammation and reduce cardiovascular risk in adults with high hsCRP and existing risk factors.

  Recruiting at 32 sites Phase 2 Eli Lilly and Company · Huntsville, Alabama and 45 other locations · NCT07783802

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.