Midlife obesity and prediabetes as triggers for later cognitive decline linked to immune dysregulation

Who could benefit from this research

What this research studies

The study focuses on people in midlife who are dealing with obesity or prediabetes and follows how these conditions might set the stage for cognitive decline as they age. It investigates a specific immune mechanism called the cGAS/STING pathway and how its dysregulation in the body could connect metabolic issues with brain inflammation. Researchers aim to map how early metabolic imbalance could influence brain health over time, with potential implications for prevention and treatment strategies. The project is conducted at Michigan State University under the leadership of Dr. Sarah Elzinga.

Why it matters

Where this research is happening

• Michigan State University
  East Lansing, United States Active

Researchers

• Principal investigator: Elzinga, Sarah — Michigan State University
• Study coordinator: Elzinga, Sarah

Related research

Other NIH-funded projects on the same topics.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.