Understanding how fasting glucose is controlled in people with and without prediabetes
Official title: The regulation of fasting glucose metabolism in people with and without prediabetes
Funded at Mayo Clinic Rochester · NIH-11384413 · Data updated 2026-11-12
This NIH grant studies how insulin and glucagon work together to control fasting glucose in people with and without prediabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 1, 2007 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $664,206 |
| NIH project number | 5R01DK078646-20 |
| Project ID | NIH-11384413 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or without prediabetes who participate in studies measuring glucose metabolism and pancreatic hormone function.
✕Less likely to help
People without prediabetes may participate in mechanistic studies but may not directly benefit in the short term.
What this research studies
If funded, researchers at Mayo Clinic Rochester will investigate how alpha and beta cells communicate to regulate glucose production during fasting and how this affects the development of prediabetes and type 2 diabetes. They will study the ways insulin and glucagon influence each other and how brief changes in hormone release might signal early problems in islet function. A novel method to measure hormone pulses will be used to identify early defects in islet cell activity. The aim is to uncover mechanisms that could lead to new strategies to prevent or delay diabetes progression.
Why it matters
Potential benefit: If successful, the work could reveal new targets to prevent fasting hyperglycemia and delay type 2 diabetes.
How similar studies have gone: Previous studies have shown that α- and β-cell interactions influence glucose regulation, though the exact roles in fasting glucose are still being explored.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Vella, Adrian — Mayo Clinic Rochester
- Study coordinator: Vella, Adrian
Related research
Other NIH-funded projects on the same topics.
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Fasting blood sugar control in people with and without prediabetes
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-
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Intermittent fasting with PD-1 inhibitors for non-small cell lung cancer
This grant tests whether a fasting-mimicking diet can boost the effectiveness of PD-1 inhibitors for people with non-small cell lung cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.