Investigating cognitive impairment in older adults with prediabetes and type 2 diabetes
Official title: Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD Project
Funded at Columbia University Health Sciences · NIH-11162996 · Data updated 2026-11-12
This study is looking at how prediabetes and type 2 diabetes might impact thinking and memory in older adults, and it aims to find ways to help prevent these issues by understanding different health factors and habits.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $250,000 |
| NIH project number | 3U19AG078558-03S1 |
| Project ID | NIH-11162996 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above who have been diagnosed with prediabetes or type 2 diabetes.
✕Less likely to help
Patients without prediabetes or type 2 diabetes, or those under 65 years of age, may not benefit from this research.
What this research studies
This research explores how prediabetes and type 2 diabetes affect cognitive function in older adults, particularly focusing on the risk factors and mechanisms that contribute to cognitive decline. It aims to understand the role of various factors such as neuropathology, glycemia, and physical activity in this high-risk population. By utilizing the Diabetes Prevention Program Outcomes Study cohort, the research will gather detailed information on participants' health and cognitive status to identify potential interventions. The findings could lead to better strategies for preventing cognitive impairment in individuals with diabetes.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for cognitive decline in older adults with diabetes.
How similar studies have gone: Previous research has shown that understanding the relationship between diabetes and cognitive impairment can lead to significant advancements in treatment approaches.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Luchsinger, Jose Alejandro — Columbia University Health Sciences
- Study coordinator: Luchsinger, Jose Alejandro
Related research
Other NIH-funded projects on the same topics.
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Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes
This grant aims to understand why some older adults with prediabetes or type 2 diabetes develop memory problems or dementia.
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Alzheimer’s and related dementia in older adults with prediabetes or type 2 diabetes
This grant aims to understand why cognitive problems occur in people 65 and older who have prediabetes or type 2 diabetes, using data from a long-running diabetes study to identify what drives memory and thinking decline.
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Alzheimer's and related dementia risk in people with prediabetes and type 2 diabetes
This project looks at brain changes, memory, medications, and health measures in older adults with prediabetes or type 2 diabetes to find what leads to dementia.
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Investigating cognitive impairment in older adults with prediabetes and type 2 diabetes
This study is looking at how prediabetes and type 2 diabetes might impact thinking and memory in older adults, especially those at risk for Alzheimer's and similar conditions, to find ways to help prevent or treat cognitive decline.
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ONWARD: Helping teens and young adults with prediabetes and type 2 diabetes get the resources they need
A study tests easy, in-clinic and post-visit resource help for teens and young adults with type 2 diabetes to address social needs that affect their health.
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Smartphone and smartwatch screening for prediabetes and type 2 diabetes
This project uses data from smartphones and smartwatches to spot early signs of prediabetes and type 2 diabetes in adults who have no symptoms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.