Continuous glucose monitoring with Diabetes Prevention Program coaching to prevent type 2 diabetes
Official title: A Novel Continuous Glucose Monitoring Enhanced DPP Intervention to Prevent Type 2 Diabetes in Adults With Prediabetes
Run by State University of New York at Buffalo · NCT07140848 · Data updated 2026-11-12
This project will try adding continuous glucose monitors to DPP coaching to help adults with prediabetes stick to healthy habits and lower their risk of developing type 2 diabetes.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | State University of New York at Buffalo Academic / other |
| Locations | 1 site (Buffalo, New York) |
| Status | Recruiting |
| Started | April 13, 2026 |
| Main results expected | March 2028 |
| Study ends | March 2028 |
| Registry record updated | November 3, 2026 |
| Trial ID | NCT07140848 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older with laboratory-defined prediabetes (HbA1c 5.7–6.4% or qualifying glucose values), a BMI ≥24 kg/m² (or ≥22 kg/m² for Asian Americans), and willingness to attend coaching and use CGM devices are ideal candidates.
✕Probably not a fit
People with diagnosed type 1 or type 2 diabetes, current CGM users, those with medical contraindications to CGM, or with significant cognitive impairment or active substance dependence are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional program pairs real-time continuous glucose monitoring (CGM) with trained Diabetes Prevention Program (DPP) coaches to provide personalized feedback on diet, activity, and daily habits. A total of 214 adults with prediabetes will participate in a 12-month program with regular check-ins and monitoring. Outcomes include changes in blood sugar measures, weight, physical activity, quality of life, and economic costs. Results will compare the CGM-plus-coaching group to a control group to see if the combination yields better, cost-effective prevention of diabetes.
Why it matters
Potential benefit: If successful, this approach could help people with prediabetes maintain lifestyle changes more effectively and reduce progression to type 2 diabetes.
How similar studies have gone: The original DPP has strong evidence for preventing diabetes, and early small studies suggest CGMs can improve glucose awareness and behavior, but combining CGM with DPP coaching is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. adults aged 18 years or older, 2. diagnosis of prediabetes, as defined by current clinical guidelines (HbA1c 5.7% to 6.4%, fasting plasma glucose 100-125 mg/dL, or 2-hour plasma glucose 140-199 mg/dL following a 75g oral glucose tolerance test), 3. body mass index (BMI) of at least 24 kg/m² (or 22 kg/m² for Asian Americans), 4. willingness to comply with all aspects of the study protocol, including attending coaching sessions and using CGM devices. Exclusion Criteria: Individuals will be excluded from the study if they 1. have a diagnosis of type 1 or type 2 diabetes, 2. are currently using CGMs or have medical contraindications to CGM use, such as severe skin allergies or implantable defibrillators, or 3. are currently enrolled in another clinical trial for prediabetes. Additionally, using validated assessments, we will exclude participants with significant dementia, alcohol or drug abuse/dependency, active psychosis, or life expectancy less than 12 months as these conditions are likely to interfere with adherence to the intervention.
Where it's running
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Division of Population Health, Department of Medicine
Buffalo, New York, United States Recruiting
Study contacts
- Study coordinator: Raphael A Fraser, PhD, MS
- Email: rfraser@buffalo.edu
- Phone: 7168295733
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.