Investigating cognitive impairment in older adults with prediabetes and type 2 diabetes
Official title: Alzheimer's Disease and Alzheimer's Disease Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD Project
Funded at Columbia University Health Sciences · NIH-10924046 · Data updated 2026-11-12
This study is looking at how prediabetes and type 2 diabetes might impact thinking and memory in older adults, especially those at risk for Alzheimer's and similar conditions, to find ways to help prevent or treat cognitive decline.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $16,500,642 |
| NIH project number | 5U19AG078558-03 |
| Project ID | NIH-10924046 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above who have been diagnosed with prediabetes or type 2 diabetes.
✕Less likely to help
Patients who are younger than 65 or do not have prediabetes or type 2 diabetes may not benefit from this research.
What this research studies
This research examines how prediabetes and type 2 diabetes affect cognitive function in older adults, particularly focusing on Alzheimer's disease and related dementias. It aims to identify the risk factors and mechanisms that contribute to cognitive decline in this high-risk population. The study will utilize data from the Diabetes Prevention Program Outcomes Study, which includes detailed health information about participants. By exploring various factors such as metabolic health, medication effects, and physical activity, the research seeks to uncover insights that could lead to better prevention and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive impairment in older adults with diabetes, potentially reducing the risk of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the links between diabetes and cognitive decline, making this approach both relevant and potentially impactful.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Luchsinger, Jose Alejandro — Columbia University Health Sciences
- Study coordinator: Luchsinger, Jose Alejandro
Related research
Other NIH-funded projects on the same topics.
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Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes
This grant aims to understand why some older adults with prediabetes or type 2 diabetes develop memory problems or dementia.
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Alzheimer’s and related dementia in older adults with prediabetes or type 2 diabetes
This grant aims to understand why cognitive problems occur in people 65 and older who have prediabetes or type 2 diabetes, using data from a long-running diabetes study to identify what drives memory and thinking decline.
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Alzheimer's and related dementia risk in people with prediabetes and type 2 diabetes
This project looks at brain changes, memory, medications, and health measures in older adults with prediabetes or type 2 diabetes to find what leads to dementia.
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Investigating cognitive impairment in older adults with prediabetes and type 2 diabetes
This study is looking at how prediabetes and type 2 diabetes might impact thinking and memory in older adults, and it aims to find ways to help prevent these issues by understanding different health factors and habits.
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ONWARD: Helping teens and young adults with prediabetes and type 2 diabetes get the resources they need
A study tests easy, in-clinic and post-visit resource help for teens and young adults with type 2 diabetes to address social needs that affect their health.
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Smartphone and smartwatch screening for prediabetes and type 2 diabetes
This project uses data from smartphones and smartwatches to spot early signs of prediabetes and type 2 diabetes in adults who have no symptoms.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.