Improving oral and systemic health in people with prediabetes using personalized hygiene advice

Improving Oral and Systemic Health in Individuals With Prediabetes Through Personalized Oral Hygiene Advice Provided by Dentists or by Artificial Intelligence: A Randomized Clinical Trial

This study is testing whether personalized oral hygiene advice from dental professionals or AI can help people with prediabetes improve their oral and overall health.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 148 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: The University of Hong Kong (other)
• Locations: 1 site (Hong Kong, Sai Ying Pun)
• Trial ID: NCT06980701 on ClinicalTrials.gov

What this trial studies

This study aims to enhance oral and systemic health in individuals with prediabetes by providing personalized oral hygiene advice through either dental professionals or artificial intelligence (AI). It recognizes the link between gum disease and prediabetes, where controlling gum inflammation can improve blood glucose levels. Participants will receive tailored guidance on maintaining oral hygiene, which is crucial for managing their condition. The study will compare the effectiveness of AI-generated advice versus traditional advice from dental professionals.

Who should consider this trial

Good fit: Ideal candidates for this study are adults over 18 years old who have prediabetes and can independently practice oral hygiene.

Not a fit: Patients with a current diagnosis of type 2 diabetes or those with significant mental illness may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to improved oral health and better management of prediabetes, potentially reducing the risk of developing diabetes.

How similar studies have performed: Other studies have shown promising results using AI for health management, suggesting this approach could be effective, though it may also be considered novel in this specific context.

Eligibility criteria

Inclusion Criteria:

* \- Subjects who are \>18 years of age and able to give informed consent.
* \- Subjects who are mentally and cognitively healthy.
* \- Subjects who have at least 6 anterior maxillary or mandibular natural teeth including incisors and canine.
* \- Subjects who are with prediabetic state with impaired HbA1c 5.7% to 6.4%, impaired fasting plasma glucose level 5.6mmol/L to 6.9 mmol/L and/or impaired plasma glucose level after 2h OGTT 7.8 mmol/L to 11.0 mmol/L.
* \- Subjects who can speak, read, or understand Cantonese to complete the satisfaction questionnaire.
* \- Subjects who can practice oral hygiene procedure (regular tooth brushing and interdental cleansing/flossing/brushing) daily on their own independently.

Exclusion Criteria:

* \- Subjects who have less than 6 anterior maxillary or mandibular natural teeth with or without dental prostheses in those area.
* \- Subjects who are with a current diagnosis or clinical history of T2DM.
* \- Subjects who have mental illness, or similar problems that unable to complete the satisfaction questionnaire.
* \- Subjects who cannot perform oral hygiene procedure (regular tooth brushing and interdental cleansing/flossing/brushing) by any condition of oral cavity such as tumor or maxillomandibular fixation.

Where this trial is running

Hong Kong, Sai Ying Pun

• Prince Philip Dental Hospital — Hong Kong, Sai Ying Pun, Hong Kong (RECRUITING)

Study contacts

• Principal investigator: Walter Y.H. Lam, Prof. — The University of Hong Kong
• Study coordinator: Walter Y.H. Lam, Prof.

Conditions: Gum Disease, Prediabetes, gum disease, prediabetes, oral health, oral hygiene