Lifestyle Metabotype Study: How Daily Habits Shape Blood Sugar

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study aims to identify lifestyle, metabolic, molecular, and neurocognitive factors that predict individual postprandial glucose fluctuations across people with prediabetes, type 2 diabetes, and those without these conditions. Participants undergo comprehensive phenotyping in the center and are monitored at home for diet, glucose, sleep, and activity during observational phases. Machine learning and metabolic data, including microbiome information, may be used to explore personalized nutrition approaches to glycemic control. The study also considers how meal timing and frequency, as well as socioeconomic and lifestyle factors, influence glycemic responses. Ketone bodies, like beta-hydroxybutyrate, are explored as potential biomarkers and energy sources under varying carbohydrate availability.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Overweight or obesity (BMI 25-40 kg/m²)
* Good knowledge of German

Exclusion Criteria:

* Weight changes of more than 5% in the last 3 months
* Night shift work
* Travel across more than one time zone in the last month before and during study participation
* Intensive regular physical activity of more than 2 hours per day
* Current pregnancy or breastfeeding
* Severe renal, liver or heart disease
* Existing or past hematological malignancies, other malignant tumors, unless successfully treated more than 12 months before study start
* Severe neurological or psychiatric disorders
* Daily alcohol consumption of more than 20 grams or more than 150 grams per week
* Use of illicit or legal drugs one week prior to study start and during study participation
* Known systemic infections
* Type 1 diabetes and rare forms of diabetes
* Diabetes treatment with insulin or sulfonylureas or diabetes medication in the absence of manifest type 2 diabetes
* Unstable thyroid dysfunction
* Blood coagulation disorders or anticoagulation therapy that cannot be interrupted
* Medications affecting nutrient absorption
* Medications with immunosuppressants or steroids (oral or parenteral)
* Current eating disorders, functional or structural digestive disorders or bariatric surgery
* Food allergies or intolerances to ingredients of the test meals
* Intermittent fasting or calorie-restricted diet four weeks prior to the start of the study or during the study
* Ketogenic diet or ketogenic supplements four weeks prior to or during module B
* Left-handedness
* Severe claustrophobia
* Electrical implants or non-removable metallic implants
* Concurrent participation in another intervention study
* Assessment by the study physician based on medical concerns precluding study participation

Where it's running

• German Institute of Human Nutrition, Dept. Molecular Metabolism and Precision Nutrition and Decision Neuroscience and Nutrition
  Potsdam, Potsdam-Rehbrücke, Germany Recruiting

Study contacts

• Principal investigator: Olga Ramich, Prof. Dr. — German Institute of Human Nutrition Potsdam-Rehbruecke and the Charité - Universitätsmedizin Berlin
• Study coordinator: Olga Ramich, Prof. Dr.
• Email: olga.ramich@dife.de
• Phone: +49 33200 882749

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Lifestyle Metabotype Study B: Understanding Personalized Glucose Responses

  This study tests how lifestyle, metabolism, and brain energy use relate to each person’s blood sugar response after meals, across people with and without prediabetes or type 2 diabetes.

  Recruiting at 2 sites German Institute of Human Nutrition · Berlin and 1 other locations · NCT07888257

• New T-UP: Engaging vulnerable students in diabetes prevention

  This project will try an online, student-tailored diabetes prevention program to help UCLA undergraduates with prediabetes or high diabetes risk lose weight.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT07225218

• Eight-hour early versus late eating windows to improve blood sugar and cardiometabolic health in overweight adults

  We will try early versus late 8-hour time-restricted eating with moderate calorie reduction to see if it improves blood sugar and heart-related health in adults who are overweight with normal glucose, prediabetes, or non-insulin-treated type 2 diabetes.

  Recruiting German Institute of Human Nutrition · Nuthetal · NCT07171281

• PortionSize Ed mobile program to support healthier eating after a recent stroke for people with prediabetes or type 2 diabetes

  See if a mobile app called PortionSize Ed helps adults who recently had a stroke and have prediabetes or type 2 diabetes follow a Mediterranean-style diet.

  Recruiting University of Hawaii · Honolulu, Hawaii · NCT07120334

• Whole Food for Families: a family whole-foods diet program to prevent type 2 diabetes

  This pilot randomized program will test whether a 12-week, family-centered, non-calorie-restricted whole-foods diet for parents with prediabetes and their children lowers adult HbA1c and improves family diet quality.

  Recruiting Vanderbilt University · Nashville, Tennessee · NCT06482944

• Comparing ketogenic and low-fat diets for diabetes management

  This study tests whether a ketogenic diet or a low-fat diet works better for managing blood sugar and overall health in people with type 2 diabetes or prediabetes.

  Recruiting University of New Mexico · Albuquerque, New Mexico · NCT06115265

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.