New T-UP: Engaging vulnerable students in diabetes prevention
Targeted Upstream Prevention (T-UP): Engaging Vulnerable Students in Diabetes Prevention
NA · University of California, Los Angeles · NCT07225218
This project will try an online, student-tailored diabetes prevention program to help UCLA undergraduates with prediabetes or high diabetes risk lose weight.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 17 Years to 25 Years |
| Sex | All |
| Sponsor | University of California, Los Angeles (other) |
| Locations | 1 site (Los Angeles, California) |
| Trial ID | NCT07225218 on ClinicalTrials.gov |
What this trial studies
This is a pre/post pilot trial that will enroll 80 UCLA undergraduates at elevated diabetes risk and randomize them to an asynchronous, AYA-tailored version of the UC Diabetes Prevention Program (DPP) or to a control condition with delayed access. Randomization will be stratified by age (≤19 vs ≥20) and sex (M/F) using block sizes of two, and the primary outcome is weight change at program completion (9 months) with a target of 5% weight loss. Participants will complete brief online lessons (about 15 minutes each) on their own schedule, and feasibility and acceptability will be measured by recruitment, retention, and participant feedback. Control participants will be offered the tailored DPP in the following academic year to maintain equipoise.
Who should consider this trial
Good fit: UCLA undergraduate students with BMI ≥25 (or ≥23 for those who self-identify as Asian) and either documented prediabetes or high risk on a CDC diabetes risk questionnaire, especially those facing food, financial, or stress-related vulnerabilities.
Not a fit: Students who are not enrolled undergraduates at UCLA, who do not meet the BMI/prediabetes or high-risk criteria, or who require more intensive in-person medical management are unlikely to benefit from this program.
Why it matters
Potential benefit: If successful, this approach could help at-risk students achieve clinically meaningful weight loss (~5%) and reduce progression to type 2 diabetes.
How similar studies have performed: The core DPP has strong evidence for preventing diabetes in adults, but fully asynchronous, AYA-tailored online adaptations for underserved college students have been less widely tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants who are currently enrolled (either full time or part time) as an undergraduate at UCLA and meet criteria for the T-UP Wellness Program (students who have a BMI of ≥25 (≥23 for those self- identifying as Asian) and either documented prediabetes or identified as high-risk on a CDC questionnaire). Exclusion Criteria: * Participants who are not currently enrolled (either full time or part time) as an undergraduate at UCLA and do not meet criteria for the T-UP Wellness Program.
Where this trial is running
Los Angeles, California
- University of California, Los Angeles — Los Angeles, California, United States (RECRUITING)
Study contacts
- Principal investigator: Lauren E Wisk, PhD — University of California, Los Angeles
- Study coordinator: Lauren E Wisk, PhD
- Email: lwisk@mednet.ucla.edu
- Phone: 310-267-5308
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Prediabetes, Type 2 Diabetes