New T-UP: Engaging vulnerable students in diabetes prevention
Official title: Targeted Upstream Prevention (T-UP): Engaging Vulnerable Students in Diabetes Prevention
Run by University of California, Los Angeles · NCT07225218 · Data updated 2026-11-12
This project will try an online, student-tailored diabetes prevention program to help UCLA undergraduates with prediabetes or high diabetes risk lose weight.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 17 Years to 25 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | University of California, Los Angeles Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Status | Recruiting |
| Started | October 14, 2025 |
| Main results expected | July 2027 |
| Study ends | August 2027 |
| Registry record updated | October 21, 2026 |
| Trial ID | NCT07225218 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
UCLA undergraduate students with BMI ≥25 (or ≥23 for those who self-identify as Asian) and either documented prediabetes or high risk on a CDC diabetes risk questionnaire, especially those facing food, financial, or stress-related vulnerabilities.
✕Probably not a fit
Students who are not enrolled undergraduates at UCLA, who do not meet the BMI/prediabetes or high-risk criteria, or who require more intensive in-person medical management are unlikely to benefit from this program.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a pre/post pilot trial that will enroll 80 UCLA undergraduates at elevated diabetes risk and randomize them to an asynchronous, AYA-tailored version of the UC Diabetes Prevention Program (DPP) or to a control condition with delayed access. Randomization will be stratified by age (≤19 vs ≥20) and sex (M/F) using block sizes of two, and the primary outcome is weight change at program completion (9 months) with a target of 5% weight loss. Participants will complete brief online lessons (about 15 minutes each) on their own schedule, and feasibility and acceptability will be measured by recruitment, retention, and participant feedback. Control participants will be offered the tailored DPP in the following academic year to maintain equipoise.
Why it matters
Potential benefit: If successful, this approach could help at-risk students achieve clinically meaningful weight loss (~5%) and reduce progression to type 2 diabetes.
How similar studies have gone: The core DPP has strong evidence for preventing diabetes in adults, but fully asynchronous, AYA-tailored online adaptations for underserved college students have been less widely tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants who are currently enrolled (either full time or part time) as an undergraduate at UCLA and meet criteria for the T-UP Wellness Program (students who have a BMI of ≥25 (≥23 for those self- identifying as Asian) and either documented prediabetes or identified as high-risk on a CDC questionnaire). Exclusion Criteria: * Participants who are not currently enrolled (either full time or part time) as an undergraduate at UCLA and do not meet criteria for the T-UP Wellness Program.
Where it's running
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University of California, Los Angeles
Los Angeles, California, United States Recruiting
Study contacts
- Principal investigator: Lauren E Wisk, PhD — University of California, Los Angeles
- Study coordinator: Lauren E Wisk, PhD
- Email: lwisk@mednet.ucla.edu
- Phone: 310-267-5308
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.