Effects of different exercise intensities on blood vessels and metabolism in prediabetes and diabetes
Official title: Impact of Exercise on Vascular and Metabolic Function Across Prediabetes and Diabetes
Funded at University of the Pacific-Stockton · NIH-11420736 · Data updated 2026-11-12
This project tests how moderate and high-intensity interval exercise affects blood vessel and fat tissue function in male and female rats with prediabetes or diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of the Pacific-Stockton NIH-funded |
| Lab location | 1 site (Stockton, United States) |
| Project start | August 1, 2026 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $122,065 |
| NIH project number | 1R16GM165339-01 |
| Project ID | NIH-11420736 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with prediabetes or type 2 diabetes who are able to participate in structured exercise programs when translated to human studies.
✕Less likely to help
Non-human studies or results from rat models may not directly translate to individual patients.
What this research studies
Researchers will study two types of interval exercise (moderate and high intensity) in type 2 diabetes and prediabetes rat models, looking at how these workouts change vascular health and metabolism in different sexes. The study uses rat models to explore the mechanisms behind exercise benefits, including effects on adipose tissue and key signaling pathways. Results could point toward tailoring exercise prescriptions to improve heart and metabolic health in people with or at risk for type 2 diabetes, considering sex and disease stage.
Why it matters
Potential benefit: If successful, the findings could inform more effective, sex-specific exercise guidance to reduce vascular and metabolic risks in people with prediabetes or type 2 diabetes.
How similar studies have gone: Prior work supports that exercise improves vascular and metabolic health, but this study adds sex- and disease-status specific insights in a rat model.
Where this research is happening
-
University of the Pacific-Stockton
Stockton, United States Active
Researchers
- Principal investigator: Rahimian, Roshanak — University of the Pacific-Stockton
- Study coordinator: Rahimian, Roshanak
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.