Effects of Time-Restricted Eating on Cardiometabolic Health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of time-restricted eating (TRE) on cardiometabolic health in individuals with obesity and prediabetes. Participants will follow a 9-hour eating window for 12 weeks without altering their body weight. The study aims to assess key metabolic outcomes, including insulin sensitivity and metabolic homeostasis, to better understand how TRE may influence cardiovascular disease risk factors. By comparing these outcomes, the trial seeks to clarify the potential benefits of TRE in improving metabolic health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* must be able to grant voluntary informed consent and comply with the study instructions
* aged 25-75 years
* men and women
* body mass index 27-45 kg/m2
* fasting plasma glucose 5.6-6.9 mmol/L, or 2h oral glucose tolerance test plasma glucose 7.8-11.1 mmol/L or haemoglobin A1C 39-46 mmol/mol or homeostasis model assessment-insulin resistance (HOMA-IR) score ≥2.73
* self-reported habitual eating period ≥ 13 h per day

Exclusion Criteria:

* shift worker
* fasting \>12 h/day more than once a week
* vegan
* \> once a week no food intake after \~1800 h
* habitually waking up before \~0400 h and sleeping before \~2100 h
* unstable weight (\>5% change the last 2 months)
* Clinical diagnosis of type 1 or 2 diabetes
* Clinical diagnosis of sleep disorder
* Clinical diagnosis of eating disorder
* Clinical diagnosis of cancer in last 5 years
* conditions that render subject unable to complete all testing procedures (including individuals with known allergies or contraindications to the medications used in this study)
* use of medications that affect the study outcome measures or increase the risk of study procedures and that cannot be temporarily discontinued (e.g., steroids, alpha- or beta-adrenergic blockers or agonists, etc.)
* smoking and illegal drug use
* pregnant or lactating
* gastrointestinal or bariatric surgery (except cholecystectomy and appendectomy)
* individuals with electromedical devises
* prisoners
* alcohol abuse

Where it's running

• Cambridge Clinical Research Center
  Cambridge, United Kingdom Recruiting

Study contacts

• Study coordinator: Maria Chondronikola
• Email: mc2425@medschl.cam.ac.uk
• Phone: 01223746784

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.