Condition
Overweight clinical trials and research
As of November 12, 2026, Find a Trial lists 120 Overweight clinical trials that are recruiting, at sites in 46 countries (most in United States (68), China (19), Germany (17)). 7 were first registered in the last 30 days. By phase: Phase 3 (32), Phase 1 (29), Phase 2 (10), Phase 1/2 (1). The most active sponsors are Novo Nordisk A/S (25), Eli Lilly and Company (16), Pfizer (5). There are also 39 NIH-funded research projects on Overweight, with $14.9 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 120Clinical trials
- 39NIH research projects
- 7New in 30 days
- 46Countries
Newest Overweight clinical trials
All recruiting trials (120)
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Berobenatide for knee pain in adults who are overweight or with obesity
This study tests berobenatide vs. placebo to see if it reduces knee pain and improves function while helping with weight in adults with knee osteoarthritis and overweight/obesity.
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Concurrent exercise program changes PCSK9 in adults with overweight
A supervised program of aerobic plus resistance training for eight weeks will test whether it lowers PCSK9 levels in adults who are overweight.
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Maridebart cafraglutide in people who switched from weekly GLP-1 receptor agonists
This study tests how much maridebart cafraglutide appears in the blood after people with overweight or obesity switch from weekly GLP-1 receptor agonists.
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EloraTZP for weight loss in adults with overweight/obesity and type 2 diabetes
This trial tests whether a coformulation of eloralintide and tirzepatide helps people with obesity or overweight and type 2 diabetes lose weight compared with tirzepatide alone.
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Monthly dose of PF-08653944 vs placebo in Chinese adults who are overweight or obese
This study tests whether berobenatide (PF-08653944) given once a month helps adults in China lose weight compared with a placebo.
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FutureShape Family: a family-based weight-management program with semaglutide for children and parents
This trial tests whether a family-centered program that combines a prescription medication (semaglutide) with lifestyle support and app-based coaching can help adults with obesity and their children who are overweight/obese.
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Home self-administration of a weight-management medicine with an autoinjector in adults who are overweight or obese
This study tests whether adults who are overweight or have obesity can successfully self-administer maridebart cafraglutide at home using an autoinjector.
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Switching to Zenagamtide From Tirzepatide in Adults With Overweight or Obesity With or Without Type 2 Diabetes
This study tests whether adults who are overweight or have obesity (with or without type 2 diabetes) can switch from tirzepatide to a new treatment called zenagamtide to find a tolerable dose.
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Switching to Zenagamtide from Semaglutide in adults with overweight or obesity, with or without type 2 diabetes
This study tests whether adults who are already taking semaglutide can successfully switch to zenagamtide at different doses to see which dose works best.
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Switching to a monthly dose of Berobenatide to help keep weight off after weight loss with semaglutide or tirzepatide
This study tests whether switching to a monthly berobenatide shot can help adults who have overweight or obesity and have already lost weight using semaglutide or tirzepatide to keep the weight off.
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Amaze 10: Testing NNC0487-0111 for Weight Loss in Japan
This study tests whether the medicine NNC0487-0111 helps adults in Japan who are overweight or have obesity lose weight, compared with a placebo.
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How meal timing and water amount affect how Zenagamtide is absorbed
This study tests whether taking Zenagamtide with different meals and water amounts changes how the medicine enters the bloodstream in adults who are overweight or have obesity.
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Testing LY4329090 in adults with overweight or obesity who are otherwise healthy
This study tests how LY4329090 works in adults with overweight or obesity who are otherwise healthy to see if it is tolerated and what side effects might occur.
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Eloralintide and birth-control pill study in women with overweight or obesity
This study tests whether eloralintide affects how oral contraceptives work in women with overweight or obesity.
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Tirzepatide for type 1 diabetes patients who are overweight or obese
This study tests whether tirzepatide can affect stomach emptying in adults with type 1 diabetes and overweight or obesity.
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Orforglipron in adults with overweight at risk for obesity-related problems
This study tests whether orforglipron can help people who are overweight and have early signs of metabolic or cardiovascular risk.
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Ribupatide PK in People with Kidney Impairment
This study tests how a single shot of ribupatide behaves in the body for people with severe kidney problems compared to those with normal kidney function.
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IBI3042: a first-in-human dose-finding study in adults with overweight or obesity
This is a Phase 1 trial testing IBI3042 in healthy adults and adults with overweight or obesity to see if it is safe and tolerable and to get a sense of how it works in the body, with some groups comparing to a placebo and, in Part B, to orforglipron.
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Weekly medicine versus placebo for overweight or obesity in Chinese adults
This study tests whether berobenatide given once weekly helps adults in China lose weight compared with a placebo.
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Weight and Metabolic Management with elénzia CONTROL in adults using or stopping GLP-1 weight loss meds
This study tests whether elénzia CONTROL can help adults manage weight for 16 weeks, either those who have never used GLP-1 meds or those who recently stopped them.
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Elecoglipron in adults who are overweight or obese with or without type 2 diabetes
This study tests whether an oral drug called elecoglipron can help adults lose weight when added to diet and exercise, compared with a placebo.
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Oral semaglutide for weight loss in adults who are overweight or have obesity
This study tests whether lower doses of oral semaglutide can help adults with overweight or obesity lose weight, compared with a placebo.
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First-in-human look at how NNC0721-8060 works in people who are overweight or obese
This early study tests whether NNC0721-8060 is safe and how it behaves in adults with overweight or obesity.
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How a new drug (NNC0487-0111) changes energy use after weight loss in adults who are overweight or have obesity
This study tests whether NNC0487-0111 changes how much energy the body uses after weight loss, compared with a low-calorie diet or placebo.
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How well different and multiple doses of BI 3034701 are tolerated in adults with overweight or obesity
This trial tests whether BI 3034701, given in varying doses, is safe and tolerated in adults who are overweight or obese and have at least one weight-related health issue.
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ABBV-295 for weight management in adults with obesity or overweight
This study tests whether ABBV-295, given as injections, helps people with obesity or overweight and related health conditions lose weight compared to placebo.
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Two versions of an injectable medicine for people with excess weight, plus placebo
This phase 3 trial tests whether cagrilintide helps adults with overweight or obesity lose weight compared to placebo.
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Dance-Based Exercise vs Clinical Pilates for Women with Overweight or Obesity
This study tests whether a 10-week dance-based exercise program or a Clinical Pilates program helps women with overweight or obesity stick with exercise and feel better about it.
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Once-daily ASC30 for adults who are overweight or obese with weight-related health issues
This study tests whether three different daily doses of ASC30 can help adults who are overweight or obese with related health problems lose weight and stay safe.
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Once-daily ASC30 to See if it helps adults with obesity or overweight and Type 2 diabetes
This study tests three daily doses of ASC30 against placebo in adults who are overweight or obese and have Type 2 diabetes to see if it helps with weight loss and safety over time.
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How Eloralintide Aims to Slow Stomach Emptying in Overweight or Obese Adults
This study tests whether Eloralintide can slow stomach emptying in adults who are overweight or obese.
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How semaglutide affects brain responses to food cues in adults with obesity and food-addiction tendencies
This study tests whether eight weeks of semaglutide changes brain dopamine responses to food cues and post-meal signals in adults with obesity and tendencies toward food addiction.
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Digital dietary help for people on GLP-1 therapy to reach better blood sugar and weight
This trial tests whether adding a digital dietary program (NutriSteppe) to usual care helps adults on GLP-1 medications see better blood sugar control and weight results.
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Zenagamtide for weight loss in adults with overweight or obesity
This study tests whether Zenagamtide tablets help adults with excess body weight lose weight compared with placebo.
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How UBT251 Changes Levels of Midazolam, Caffeine, and Warfarin in People with Overweight or Obesity
This study tests whether UBT251 can be safely used with common medicines like midazolam, caffeine, and warfarin in adults who are overweight or obese.
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How UBT251 works with birth control pills in women who are overweight or obese
This study tests whether UBT251, taken with oral contraceptives and with an added option of acetaminophen, is safe and effective for women who are overweight or obese and unable to become pregnant.
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Long-term test of maridebart cafraglutide in people who are overweight or have obesity
This trial tests maridebart cafraglutide versus placebo to see if long-term treatment helps people who are overweight or obese manage weight safely and tolerably.
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Long-term test of maridebart cafraglutide for obesity and type 2 diabetes
This extension study tests whether maridebart cafraglutide remains effective and safe for people with obesity and type 2 diabetes who previously completed a parent trial.
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Impact of Weight on Work in Medical Residents
This study tests whether being overweight or obese affects how medical residents perform at work and feel about their quality of life over a year.
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Enicepatide in people who are overweight or obese, with or without Type 2 diabetes
This study tests whether enicepatide helps people who are overweight or have obesity, with or without Type 2 diabetes, lose weight when added to a reduced-calorie diet and more activity.
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Can Zenagamtide help people with excess weight lose more than Semaglutide
This study tests whether Zenagamtide can help adults with overweight or obesity lose weight more effectively than Semaglutide or placebos.
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Eloralintide (LY3841136) vs placebo in people who are overweight or obese
This study tests whether eloralintide can improve insulin sensitivity, metabolism, and body weight compared to placebo in adults who are overweight or obese.
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Blood-level and safety study of LY4174794 in adults who are overweight or obese
This study tests how safe LY4174794 is and how it behaves in the body of adults who are overweight or obese but otherwise healthy.
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Aleniglipron for adults with overweight/obesity and type 2 diabetes
A long-term test to see if aleniglipron helps weight loss and blood sugar control in adults who are overweight or obese and have type 2 diabetes.
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Aleniglipron for weight management in obesity or overweight with a related condition
This study tests whether aleniglipron, taken daily, helps people with obesity or overweight plus a weight-related condition lose weight when added to a reduced-calorie diet and more activity, compared with a placebo.
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Oral VRB-103 Alone or With VRB-101 for Obesity/Overweight
This study tests whether oral VRB-103, alone or with VRB-101, is safe and tolerable in adults who are overweight or obese.
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Confident Moves: See if a web-based program helps adults with obesity stay more active
This study tests whether a web-based program called Confident Moves can help adults with obesity be more physically active than standard obesity care alone.
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See if cagrilintide is tolerated in people with overweight or obesity who can't continue GLP-1-RA therapy due to GI side effects
This study tests whether cagrilintide is safe and tolerated in adults with overweight or obesity who previously had GI side effects from GLP-1-RA medicines, compared with placebo, over about eight months.
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Two versions of cagrilintide in adults with overweight or obesity
This study tests two versions of the drug cagrilintide to see how their blood levels compare in adults who are overweight or obese.
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Berobenatide (PF-08653944) for overweight or obesity in adults
This study tests whether berobenatide helps adults with overweight or obesity lose weight compared with a placebo.
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Weight management with macupatide and eloralintide, alone or together
This study tests whether macupatide and eloralintide, by themselves or in combination, can help adults who are overweight or have obesity lose weight compared with placebo.
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Blood levels and tolerance of NNC0487-0111 in people with overweight/obesity and varying liver function
This study tests a new medicine (NNC0487-0111) to see if it is safe and how it behaves in people with overweight or obesity, with or without liver impairment.
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Test of NNC0497-0040 in healthy adults, people with overweight/obesity, and adults with type 1 diabetes with overweight
This study tests whether NNC0497-0040 is safe and tolerable and can help people who are healthy, those with overweight or obesity, and those with type 1 diabetes and overweight or obesity.
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Obesity's effect on muscle insulin action and cardiorespiratory fitness in type 1 diabetes
This will see if muscle insulin resistance and excess weight are linked to lower cardio fitness in adults with type 1 diabetes compared with healthy controls before and after a high-intensity interval training program.
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NNC0487-0111 for weight loss and sleep apnea in adults with obesity and OSA on PAP
A phase 3 study will test whether the medicine NNC0487-0111 helps adults who are overweight or have obesity and treated sleep apnea lose weight and improve sleep apnea symptoms compared with placebo.
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Amazing weight loss and sleep apnea treatment with NNC0487-0111
This study tests whether weekly injections of NNC0487-0111 help adults with overweight or obesity and sleep apnea who aren’t using CPAP to lose weight and improve breathing during sleep.
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How a new medicine (NNC0113-5840) may help with overweight or obesity
This study tests whether NNC0113-5840 is safe and working to help adults who are overweight or have obesity, compared to a placebo.
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How cagrilintide affects appetite and food intake in adults with overweight or obesity
This study tests whether cagrilintide changes how much people with overweight or obesity eat compared with a placebo.
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Amaze 6: Testing NNC0487-0111 to help people with overweight and knee osteoarthritis lose weight and ease pain
This study tests whether weekly injections of NNC0487-0111 help adults with overweight or obesity and knee osteoarthritis lose weight and reduce knee pain compared with a placebo.
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SA030 Injection in Adults with Overweight or Obesity (Phase 1)
This first-in-human study tests a single dose of SA030 to see if it is safe and well tolerated in adults who are overweight or obese.
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Low-level laser acupuncture to improve body shape and composition in overweight menopausal women
This trial will test whether adding low-level multi-acupoint laser acupuncture to WHO-recommended diet and exercise helps overweight or obese menopausal women lose weight and improve body composition.
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See if IBI362 lowers blood pressure in adults who are overweight or obese
This study tests whether the drug IBI362 can help adults with high blood pressure who are overweight or obese, compared to placebo.
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Semaglutide nasal spray for overweight or obese adults
This study will test whether a semaglutide nasal spray is safe, well tolerated, and how it is absorbed in adults who are overweight or have obesity compared with a placebo and an injected semaglutide control.
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Structured management of adult cardiovascular risk factors in outpatient care
This project will try a structured clinic approach to managing blood pressure, cholesterol, diabetes, and weight in adults with cardiovascular risk factors to see if it improves risk control and outcomes.
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Safety testing of NNC6989-0001 in adults with overweight or obesity
This study will test whether the medicine NNC6989-0001 is safe and tolerable for adults who are overweight or have obesity.
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Extra virgin olive oil for liver and metabolic health in MASLD
This trial will test whether taking extra virgin olive oil every day helps adults with MASLD and overweight reduce liver fat and improve blood sugar and cholesterol.
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Weekly injections of GIP (NNC0480-0389) plus amylin (cagrilintide) to see stomach side effects in adults with overweight or obesity
This trial tests whether adding a GIP injection (NNC0480-0389) to weekly cagrilintide changes stomach-related side effects in adults with overweight or obesity.
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Different doses of UBT251 for adults with overweight or obesity
This trial will test whether different doses of UBT251 help adults with overweight or obesity by comparing the medicine to a placebo.
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Eloralintide for people with persistent obesity on weekly incretin therapy
This trial will test whether adding eloralintide helps adults with persistent obesity or overweight who are already taking a weekly incretin medication, with or without type 2 diabetes.
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Eloralintide for people with obstructive sleep apnea who are overweight or obese
This study will test whether the drug eloralintide helps adults with moderate-to-severe obstructive sleep apnea who are overweight or obese, whether they use PAP therapy or not.
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Genotype-based versus standard dietary counseling to reduce weight and body fat.
This test sees if dietary advice based on your genes helps Greek adults with overweight lose more weight and reduce body fat compared with standard dietary advice.
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Supervised exercise after bariatric surgery to protect muscle and bone
This program tests whether supervised exercise after gastric bypass or sleeve surgery helps preserve muscle mass and bone density in adults.
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Eloralintide for weight loss in adults with obesity or overweight without type 2 diabetes
This trial tests whether eloralintide helps adults with obesity or overweight (who do not have type 2 diabetes) lose weight and is safe.
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Comparing a standard versus an intensified interactive Get Ready app to support patients having bariatric surgery
This trial tests whether an intensified, interactive version of the Get Ready smartphone app helps people having bariatric surgery follow their pre- and post‑operative plan better than the standard app.
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Eloralintide for weight loss in adults with overweight or obesity and type 2 diabetes
This study will test whether eloralintide helps adults with overweight or obesity and type 2 diabetes lose more weight than a placebo over about 75 weeks.
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CagriSema and cagrilintide for weight loss in children and teens with excess body weight
This study will see if CagriSema or cagrilintide help children and teens (ages 8 to under 18) with excess body weight lose weight compared with semaglutide or a placebo.
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Phase 1/2a: RN3161 alone and with tirzepatide for safety, how the drug works in the body, and effects on weight in adults with overweight or obesity
This trial will test RN3161 by itself in healthy volunteers and RN3161 with tirzepatide in adults with overweight or obesity to see if it is safe and changes body weight.
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Grape powder effects on gut and immune health in adults with obesity
This 12-week test will see if taking 48 g per day of freeze-dried grape powder changes the gut microbiome and immune markers in adults aged 30–45 with obesity.
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Probiotic Support for GLP-1 RA Weight Loss in Obesity
This study tests whether adding probiotics helps people starting GLP-1 receptor agonist treatment for obesity see if they tolerate the medication better and possibly lose more weight.
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Postpartum program to prevent cardiometabolic problems after preeclampsia
This study will test a 9-month app-based support program to lower blood pressure and help with weight loss in first-time mothers who recently had preeclampsia.
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Managing multiple medications in older adults with chronic diseases
This project will see if taking many different medicines changes the health outlook of people aged 65 and older who have chronic conditions.
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Eight-hour early versus late eating windows to improve blood sugar and cardiometabolic health in overweight adults
We will try early versus late 8-hour time-restricted eating with moderate calorie reduction to see if it improves blood sugar and heart-related health in adults who are overweight with normal glucose, prediabetes, or non-insulin-treated type 2 diabetes.
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Satiating protein or fiber bars with a reduced-calorie diet for weight, joint, and cardiometabolic health
We will test whether eating three satiating protein or fiber bars per day along with a modest reduced-calorie diet helps adults with overweight or obesity lose weight and improve joint and cardiometabolic health.
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Fast In‑Bed Tracking (FIT) weight-loss program using a bed-integrated scale for wheelchair users
We will test whether giving overweight wheelchair users a bed-integrated smart scale alongside an adapted weight-loss program helps them lose more weight than the program alone.
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Fueling Strong Hearts for South Carolina stroke survivors.
This program will test whether a virtual lifestyle program that adds medically tailored groceries to a peer-led exercise and nutrition class helps adults 45–80 with chronic stroke and overweight or obesity improve activity, diet, and quality of life.
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UBT251 injection for adults with overweight or obesity and chronic kidney disease
This randomized, double-blind trial will test whether UBT251 injections help obese or overweight adults with chronic kidney disease.
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Support healthy emotional co-regulation between mothers with PCOS and obesity and their infants
This program will try a brief, multimodal ECoFam intervention to see if it improves emotional connection and reduces depressive symptoms in mothers with PCOS and obesity and their infants.
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Follow-up care for people five years after bariatric surgery who were lost to follow-up
This project will try to compare health outcomes and care needs for people who had bariatric surgery and either were lost to follow-up or remained under follow-up five years after their operation.
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Pressure-support versus T-piece breathing test for overweight and obese adults on ventilators
This test will see if a one-hour pressure-support or T-piece breathing trial helps overweight and obese adults on a ventilator be successfully extubated without needing reintubation within 72 hours.
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EndoZip versus Apollo ESG for weight loss in people with obesity
This test will see if the EndoZip procedure helps adults with obesity who haven't lost weight through non-surgical methods lose more weight and is as safe as the Apollo ESG procedure.
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GLP-1 Formula to boost GLP-1 and improve blood sugar control
This will test whether a multi-ingredient GLP-1 dietary supplement can raise GLP-1 levels and improve blood sugar and insulin responses in adults with higher body fat.
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Mobile app training to strengthen control over food
This project tests whether a four-week mobile app (FoodTraining) can strengthen food-related self-control for people with obesity, binge-eating disorder, or bulimia who are receiving usual outpatient care.
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Behavioral therapy plus GLP-1 medicines for binge eating and weight in people with obesity
This project will try adding GLP-1 medications to a lifestyle program with CBT-E to see if they reduce binge eating and help adults with obesity lose weight and cope better.
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Long-term weight loss using a galactooligosaccharide (GOS) chewing gum
This study will see if a chewing gum containing galactooligosaccharides (GOS) helps adults with overweight (BMI >25) lower their weight and change their oral and gut microbiomes.
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KDS2010 for weight loss in adults with overweight or obesity
This trial will test whether daily KDS2010 helps adults with overweight or obesity lose weight safely compared with a placebo.
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Testing HRS-5817 injections for safety in adults with obesity
This will test whether subcutaneous HRS-5817 injections are safe and how the body processes them in adults with obesity.
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Optimizing meal timing to improve health in night shift workers
This study tests if changing when night shift workers eat can help them lose weight and improve their overall health.
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Using blueberries to improve health in women with prediabetes
This study is testing if eating freeze-dried wild blueberry powder can help improve health, brain function, and gut health in women with prediabetes.
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Effects of wild blueberries on heart, brain, and gut health in adults with high blood pressure
This study tests if eating freeze-dried wild blueberries can improve heart health, brain function, and gut health in adults aged 45-65 with high blood pressure.
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Evaluating Orforglipron for Adolescents with Obesity or Overweight
This study is testing if an oral medication called orforglipron can help adolescents who are overweight or obese improve their weight and health over 18 months.
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A trial for treating obesity in children and adolescents
This study is testing different medications to see if they can help kids and teens aged 12 to 17 who struggle with obesity and have tried to lose weight before.
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HealthyTogether: Dyadic 14-week virtual weight-loss program for Veterans and a support person
This program will see if a 14-week, eight-session virtual weight-loss program that includes Veterans and a close support person helps Veterans with obesity lose weight.
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Park-based fitness program for older adults
This study is testing whether a fitness program in local parks can help older adults aged 50 and up improve their heart health and stay active.
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Park-based youth physical activity program for health promotion
This study is testing a fun afterschool program in parks that includes sports and nutrition lessons to see if it helps kids aged 6-14 get fitter and feel better mentally.
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Assessing how meal timing affects glucose tolerance in young people
This study is testing if eating meals at the right times for their body clocks can help young people aged 17-23 manage their blood sugar better.
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Does starting with a low-carb versus a low-fat diet change how much body fat you lose?
This will try whether starting with a low-carb or a low-fat diet changes body fat loss in adults with overweight or obesity over two back-to-back four-week diets.
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Investigating how reduced physical activity affects appetite in healthy men
This study is testing how cutting back on physical activity affects appetite and food choices in healthy men aged 40-55.
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Using semaglutide to help manage weight after quitting smoking
This study is testing if a weight loss medication called semaglutide can help people who have recently quit smoking manage their weight better.
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Evaluating interventions for managing obesity and overweight
This study is testing different new treatments to see if they can help people with obesity and overweight manage their weight safely and effectively.
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Effects of Nicotinamide Riboside on Fat Metabolism and Energy Use
This study is testing whether taking nicotinamide riboside along with a low-carb diet can help adults with overweight or obesity burn fat and use energy better while they sleep.
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Effects of weight loss on heart function in obese patients with heart failure
This study tests if losing weight can help people with heart failure feel better and improve their heart function.
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Using tirzepatide to improve metabolic health in people with obesity or overweight
This study is testing if tirzepatide can help people with obesity or being overweight improve their metabolic health and lose weight over 22 weeks.
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Nutrition therapy program for obesity and diabetes in low-income individuals
This study tests a special meal replacement program to see if it helps low-income people with obesity and diabetes lose weight and manage their blood sugar better.
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Optimizing diet and physical activity for taxi drivers
This study is trying to help taxi drivers who are overweight or obese make healthier choices about their diet and exercise through personalized support and tools.
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Switching from animal to plant-based protein for managing type 2 diabetes
This study is testing if switching from animal protein to a plant-based diet can help people with type 2 diabetes and extra weight manage their blood sugar better.
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Exploring time-restricted feeding and protein's role in obesity management
This study tests if eating during specific hours and taking protein supplements can help overweight and obese adults manage their weight and improve their metabolism.
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Evaluating the effects of orange peel fermentation on reducing body fat in adults
This study is testing if eating fermented orange peel can help adults with overweight or fatty liver disease lose body fat.
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Improving blood sugar control with electrical stimulation
This study is testing if electrical stimulation can help overweight and obese people control their blood sugar better when combined with different types of exercise.
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Nutrition and exercise interventions for prostate cancer survivors
This study tests whether personalized nutrition and exercise plans can help prostate cancer survivors feel stronger and healthier while they are receiving hormone therapy.
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Effects of sucralose on how drugs are absorbed and metabolized
This study is testing how the artificial sweetener sucralose affects how well medications are absorbed and processed in healthy overweight women.
NIH-funded research (39)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Game-based mobile app to help pregnant women with overweight/obesity manage weight in Nepal
A new app designed for pregnant women in Nepal with overweight or obesity to help manage weight gain during pregnancy and reduce weight retention after birth.
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Nutrition and exercise plan to help overweight cancer survivors, using multi-omics to tailor care
A cancer survivorship program combines a tailored diet and exercise plan with multi-omics data to personalize care for adults with overweight or obesity.
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PROGRESS: preventing overweight in early childhood for rural, low‑income families
A program in rural, low‑income communities will test a strengthened parenting approach to help infants grow healthily and reduce future risk of overweight and type 2 diabetes.
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The role of gut-excreted compounds in how kids grow and risk overweight during early complementary feeding
A study will explore how poop-borne small molecules from diet and microbes relate to growth and overweight risk in children during the transition to solid foods.
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Mindful Movement: guided imagery app to boost activity in adults with overweight or obesity
A researcher-led plan to create and test an easy-to-use guided imagery app that helps adults with overweight or obesity stay more physically active.
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Game-based mobile app to help pregnant women with overweight/obesity in Nepal manage weight
A mobile app designed for pregnant women in Nepal who start pregnancy overweight or obese to help them manage weight gain and reduce postpartum weight retention.
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Telehealth Parent-Only Treatment for Kids with Autism and Overweight/Obesity
A telehealth program helps parents of children with autism and overweight/obesity lose weight and improve behaviors, using parent-focused sessions delivered remotely.
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Adding yoga to a weight-loss program for adults with overweight or obesity
This trial compares whether adding regular yoga to a standard behavioral weight-loss program helps adults with overweight or obesity lose more weight over 12 months.
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How weight change affects knee osteoarthritis in people who are overweight or obese
This project looks at how losing or gaining weight affects knee arthritis in adults who are overweight or obese.
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Metformin for asthma in overweight and obese adults
This project tests whether metformin can help improve asthma control in overweight and obese adults.
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Tirzepatide for adults with alcohol use disorder and overweight or obesity
This will see if the weight-loss medication tirzepatide can help adults with alcohol use disorder who are overweight or obese cut back on drinking and improve health measures.
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Understanding how phthalate exposure before birth affects childhood weight and if certain diets can help
This project explores how exposure to common chemicals before birth might affect a child's weight and if healthy eating habits can offer protection.
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Better Blood Sugar Goals for Pregnant Women with Gestational Diabetes Who Are Overweight or Obese
This project looks at whether stricter blood sugar goals can help pregnant women who have gestational diabetes and are also overweight or obese have healthier pregnancies and babies.
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Helping overweight and obese Veterans become more active using games and social support
This project is testing if a fun, game-like program with social encouragement can help overweight and obese Veterans become more physically active.
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Telehealth Support for Parents of Children with Autism and Weight Concerns
This project helps parents of children with autism spectrum disorder who are also overweight or obese learn strategies to support their child's health through online sessions.
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Effects of daily calorie reduction on kidney health in overweight adults with ADPKD
This study is looking at how eating fewer calories each day might help improve kidney health for adults with autosomal dominant polycystic kidney disease (ADPKD) who are overweight or obese, and it aims to see if this can slow down kidney problems while also helping with weight management.
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Weight Loss, Bone Health, and Fracture Risk in Type 2 Diabetes
This project explores why people with type 2 diabetes who lose weight through an intensive program might have a higher chance of bone fractures.
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Creating a program to help adults maintain weight loss and prevent regain
This study is all about helping adults who have lost weight keep it off for good by offering personalized support and strategies that adapt to their needs, making it easier for them to manage their weight in the long run.
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Investigating how yoga can enhance weight loss in adults with obesity
This study is looking at whether adding yoga to a weight loss program helps adults who are overweight or obese lose more weight and improve their health compared to just doing regular exercise, and you could help us learn more about this by joining!
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Using multi-omics to improve nutrition for cancer survivors with overweight and obesity
This study is all about helping cancer survivors who are overweight or obese by creating a personalized nutrition and exercise program that uses their unique health information to improve their overall well-being.
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Effects of sedentary time on heart function in youth with overweight or obesity
This study is looking at how sitting too much might impact the heart's health in young people who are overweight or obese, to help find ways to keep their hearts healthier.
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Evaluating Tirzepatide for treating alcohol use disorder and obesity in adults
This study is looking at how well Tirzepatide, a new weight loss medication, can help adults who are overweight or obese and also have trouble with alcohol use, by seeing if it can reduce their drinking and help them lose weight for better health.
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Helping parents promote healthy eating and exercise in pediatric cancer survivors with obesity
This study is helping families of kids aged 5-11 who have survived cancer and are dealing with being overweight or obese by encouraging parents to promote healthy eating and exercise, making it easier for everyone to adopt better habits together.
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How prenatal exposure to phthalates affects childhood obesity and dietary strategies to protect against it
This study is looking at how being exposed to certain chemicals during pregnancy might affect a child's weight as they grow up, and it will also explore ways to help reduce any weight gain linked to these chemicals through diet.
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Effects of chemical exposure on weight loss in Hispanic children
This study is looking at how certain chemicals in our environment might affect weight loss in overweight and obese Hispanic kids who are part of a community weight loss program, by checking their weight and health before and after a 10-week program.
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Using metformin to help manage asthma in overweight and obese individuals
This study is looking at whether metformin, a diabetes medication, can help improve asthma symptoms in overweight and obese people, and it will involve a six-month trial where some participants will take the medication while others will take a placebo, all while making it easy for people to join from home.
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Helping overweight and obese veterans manage their weight successfully
This study is looking for veterans who are struggling with obesity and want to improve their health by trying a special weight loss program that includes a low-calorie diet and intermittent fasting, all designed to help them lose weight and feel better over 12 weeks.
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Understanding eating control issues in Black adolescents with obesity and the impact of social factors.
This study is looking at how social situations and experiences of racial discrimination impact eating habits in Black teens who are overweight or obese, and it aims to understand their feelings of losing control over eating by talking to them and gathering real-time information about their daily lives.
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How the timing and nutrient status of aerobic exercise affects energy metabolism in adults with overweight and obesity
This study is looking at how the time of day you exercise—morning or evening—and whether you've eaten before working out affects how your body burns energy, which could help people who are overweight or obese find better ways to lose weight and improve their health.
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Improving emotional skills to help teens manage their weight
This study is all about helping teens aged 12 to 19 who are dealing with being overweight by teaching them how to manage their emotions better, which can lead to healthier eating and more active lifestyles.
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Telehealth treatment for parents of children with autism and obesity
This study is testing a new online program to help parents of children with autism who are also struggling with being overweight, giving them helpful tips to manage their child's weight from the comfort of home.
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Understanding how executive functioning affects weight and eating behaviors in children with obesity
This study is looking at how kids and teens who are overweight or obese can improve their eating habits and weight by understanding how their thinking skills, like decision-making and self-control, affect their eating choices.
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How weight changes impact knee osteoarthritis in overweight individuals
This study is looking at how losing or gaining weight might change how knee osteoarthritis gets worse in people who are overweight or obese, with the hope of finding ways to help keep their knees healthier for longer.
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Using step counts to improve body weight and heart health in overweight adults
This study is looking at how setting daily step goals can help overweight and obese adults get healthier by improving their body shape and lowering health risks, all while enjoying their favorite foods over an eight-month program.
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Effects of chemical exposure on weight loss in Hispanic children
This study is looking at how certain chemicals in our environment might affect weight loss in overweight and obese Hispanic kids who are part of a community weight loss program, by checking their weight and health before and after a 10-week program.
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Improving asthma control in overweight adults with late-onset asthma using L-citrulline
This study is looking at how taking L-citrulline might help overweight adults who developed asthma later in life by improving their breathing and reducing asthma symptoms.
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Impact of prenatal milk expression on breastfeeding success in overweight and obese women
This study is looking at how teaching expectant moms who are overweight or obese to express milk before their baby arrives can help them have a better breastfeeding experience.
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How sleep affects eating behaviors in children with overweight or obesity
This study looks at how sleep affects eating habits in kids who are overweight or obese, hoping to find ways to help them make healthier choices and feel better overall.
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Using mobile health tools to help overweight and obese women manage weight gain during pregnancy
This study is looking at how using mobile health tools can help pregnant women who are overweight or obese manage their weight gain in a way that fits their needs, so both they and their babies can be healthier.
Related topics
Quick answers
How many Overweight clinical trials are recruiting right now?
120, as of November 12, 2026. 7 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 46 countries. The most sites are in United States (68 trials), China (19 trials), Germany (17 trials), Spain (14 trials), Japan (13 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 3: 32, Phase 1: 29, Phase 2: 10, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.