DAG Oil for Metabolic Risk in Prediabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study assigns middle-aged and older adults with prediabetes to replace their cooking oil with DAG oil for four weeks, while a control group uses colza oil. All other lifestyle factors are kept the same to isolate the effect of DAG oil on glycemic regulation, lipid metabolism, and body composition. Participants must consume all study-provided meals and meet specific metabolic and health criteria. Exclusion criteria include diabetes, certain medications, recent weight changes, and other health conditions that could confound results. The trial is led by The First Affiliated Hospital of Guangdong Pharmaceutical University with collaboration from Sun Yat-sen University and is conducted in Guangzhou/Beijing area locations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged 40-75 years.
2. Diagnosed with prediabetes according to American Diabetes Association (ADA) criteria: including fasting plasma glucose (FPG) levels of 5.6-6.9 mmol/L, and/or 2-hour postprandial glucose (OGTT-2h) levels of 7.8-11.1 mmol/L, and/or glycated hemoglobin (HbA1c) levels of 5.7%-6.4%.
3. Body mass index (BMI) ≥ 24 kg/m².
4. No plans to relocate or travel extensively in the next three months.
5. Willing to consume all study-provided meals throughout the intervention.
6. Willing and able to provide written informed consent.

Exclusion Criteria:

1. Diagnosis of diabetes (Type 1 or Type 2).
2. Current use of any glucose-lowering medication.
3. Use of appetite suppressants or hormonal medications.
4. History of bariatric surgery, or weight change \>5% in the past 3 months.
5. Alcohol consumption \>40 g/day.
6. Use of antibiotics, probiotics, or prebiotics within the past 3 months.
7. Pregnancy, lactation or planning pregnancy.
8. History of severe cardiovascular disease, malignancy, autoimmune disease, cognitive impairment, or severe dysfunction of thyroid, liver, kidney, or digestive system.
9. Inability to comprehend information, communicate effectively, or comply with the study protocol.

Where it's running

• Beijing Street
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: QiuYe Dr. Lan
• Email: lanqiuye@gdpu.edu.cn
• Phone: +86-18520395821

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.