Effects of Mirabegron on Beige Fat Activation in Prediabetic Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the impact of the drug mirabegron, a specific ß3 adrenergic receptor agonist, on glucose tolerance and adipose tissue in individuals with prediabetes. The study aims to explore how mirabegron can activate beige adipose tissue, which may help improve insulin sensitivity and glucose homeostasis. Participants will be randomly assigned to receive either mirabegron or a placebo, and their metabolic responses will be monitored throughout the trial. The research is based on the premise that activating beige fat could provide a novel approach to managing prediabetes and obesity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* BMI 27-45
* prediabetes (A1c 5.7-6.4)
* impaired fasting glucose or impaired glucose tolerance

Exclusion Criteria:

* diabetes
* chronic use of anti-diabetic medication
* acute or chronic inflammatory condition
* unstable medical condition
* cancer
* renal insufficiency
* any contraindication for Mirabegron
* BMI \>45

Where it's running

• University of Kentucky
  Lexington, Kentucky, United States Recruiting

Study contacts

• Principal investigator: Philip Kern, MD — University of Kentucky
• Study coordinator: Zach Leicht
• Email: zachary.leicht@uky.edu
• Phone: 859-218-1397

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.