Comprehensive periodontal care to help prediabetes and gum health
Official title: Comprehensive Periodontal Therapy to Improve Oral and Cardiometabolic Health in Prediabetes
Funded at Mayo Clinic Rochester · NIH-11366654 · Data updated 2026-11-12
A new Mayo Clinic study will test whether comprehensive gum treatment can slow the worsening of blood sugar and gum disease in adults with prediabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $575,803 |
| NIH project number | 1UG3DE035059-01A1 |
| Project ID | NIH-11366654 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with prediabetes and periodontitis who can participate at Mayo Clinic Rochester or affiliated Apple sites.
✕Less likely to help
People without prediabetes or significant gum disease may not benefit from this specific intervention.
What this research studies
If you have prediabetes and gum disease, this study will test a full dental treatment approach to see if improving your gum health can also help stabilize blood sugar. Researchers will use a pragmatic randomized design, recruiting from Mayo Clinic Health System and Apple locations, to compare comprehensive periodontal therapy with standard care. The goal is to see if treating the mouth can slow progression toward diabetes and reduce gum inflammation, with attention to real-world applicability and maintenance care.
Why it matters
Potential benefit: If successful, this approach could provide a dual benefit of better gum health and delayed diabetes progression.
How similar studies have gone: Prior trials show gum treatment can improve glycemic control in people with diabetes, but this study tests the effect in prediabetes.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Demmer, Ryan T. — Mayo Clinic Rochester
- Study coordinator: Demmer, Ryan T.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.