Genes and GLP-1 treatment response in Mexican‑American adults with prediabetes
Official title: Pharmacogenetics of the Response to GLP-1 in Mexican-Americans with Prediabetes
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11086079 · Data updated 2026-11-12
This project checks if genetic differences change how Mexican‑American adults with prediabetes respond to GLP‑1 therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 9, 2021 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $701,211 |
| NIH project number | 5R01DK127084-05 |
| Project ID | NIH-11086079 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21 years or older) who identify as Mexican‑American/Hispanic with prediabetes and who are willing to provide blood samples and participate in GLP‑1 exposure visits are ideal candidates.
✕Less likely to help
People with established type 2 diabetes, individuals who are not Hispanic/Latino, or those unwilling to undergo blood draws or study visits may not directly benefit from this study's findings.
What this research studies
If you join, researchers will collect blood and clinical information and give or measure GLP‑1 exposure to see how your body and genes respond. They will look at specific genetic variants and measure gene activity (RNA) before and after GLP‑1 to find patterns that link genes to treatment response. The team focuses on Mexican‑American/Hispanic adults with prediabetes to learn why some people get more benefit or side effects than others. Results are meant to help doctors pick the right diabetes prevention or treatment options for people like you.
Why it matters
Potential benefit: If successful, this work could help predict who will benefit from GLP‑1 treatments and guide more personalized prediabetes care for Mexican‑American patients.
How similar studies have gone: Previous genetic studies (mostly in non‑Hispanic white groups) found links between genes and GLP‑1 response, but mechanistic RNA‑sequencing work in Mexican‑Americans is relatively new.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Gutierrez, Absalon Dennis — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Gutierrez, Absalon Dennis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.