Condition
Liver Cirrhosis clinical trials and research
As of November 12, 2026, Find a Trial lists 57 Liver Cirrhosis clinical trials that are recruiting, at sites in 33 countries (most in China (11), Germany (9), Austria (7)). 1 was first registered in the last 30 days. By phase: Phase 2 (4), Phase 4 (3), Phase 3 (3), Phase 1 (1). The most active sponsors are Medical University of Vienna (3), Medical University of Graz (2), Massachusetts General Hospital (2). There are also 21 NIH-funded research projects on Liver Cirrhosis, with $13.6 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 57Clinical trials
- 21NIH research projects
- 1New in 30 days
- 33Countries
Newest Liver Cirrhosis clinical trials
All recruiting trials (57)
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Using spleen size to help detect gastroesophageal varices in compensated cirrhosis
This study tests whether ultrasound measurements of spleen size can help identify esophageal varices in adults with compensated cirrhosis, compared with the standard endoscopy test.
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Laparoscopic liver and spleen removal for small liver cancer in people with cirrhosis and enlarged spleen
This study tests whether removing part of the liver and the spleen during one operation helps people with small liver cancers and hypersplenism by improving liver function and immune balance.
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Coil-assisted small-diameter stent shunt reduction for refractory HE after TIPS
A coil-assisted, small-diameter covered-stent technique is being tested to see if it can safely and effectively reduce shunt flow and lessen recurrent hepatic encephalopathy in people with a prior TIPS.
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Foscenvivint in HIV/HCV co-infected adults with liver cirrhosis and hemophilia
This study tests whether foscenvivint can help people with liver cirrhosis due to HIV/HCV co-infection who also have hemophilia.
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Austrian PBC Registry
This registry follows adults with primary biliary cholangitis in Austrian centers to see how the disease develops over time and how biomarkers relate to complications and symptoms.
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Reference framework for outcomes after machine-preserved liver transplantation in Europe
This study tests how liver transplants that use machine perfusion perform in real-world practice, to see how different perfusion methods relate to outcomes for adults in Europe.
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Even protein distribution plus exercise for people awaiting liver transplant
This trial tests whether spreading daily protein evenly and combining it with a 12-week exercise program improves nutrition, muscle mass, and function in people waiting for a liver transplant compared with uneven protein timing or usual advice.
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Blood clotting and portal vein changes during TIPS placement in cirrhosis
This project will see how blood clotting in the body and in the portal vein changes in adults with cirrhosis who are having a TIPS placed.
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Developing and testing the Liver Cirrhosis Cognitive Decline Scale (LiCCoS)
This project will test a short questionnaire called LiCCoS to see if it can spot thinking and everyday mental problems in adults with liver cirrhosis.
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Autologous Bone Marrow Cells With Wharton Gel Exosomes for Liver Cirrhosis
Doctors are testing whether using a patient’s own bone marrow cells with Wharton gel exosomes can help the liver repair itself in people with liver cirrhosis.
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Underdilated stent technique to reduce encephalopathy after TIPS
This trial tries to see if using an underdilated stent (smaller balloon dilation before placing a standard covered stent) during TIPS lowers the chance of hepatic encephalopathy for people with cirrhosis who need TIPS for variceal bleeding or refractory ascites.
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DIALIVE 2.0 Liver Dialysis for ACLF in adults with cirrhosis
This trial tests whether adding the DIALIVE 2.0 liver dialysis device to standard care can help adults with acute-on-chronic liver failure and cirrhosis see improvement.
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BI 3802876 for adults with compensated cirrhosis from MASH
This study will test whether BI 3802876 given by IV infusion is tolerated and how different doses are handled in adults with compensated cirrhosis due to MASH.
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Phycocyanin for liver protection in fibrosis and cirrhosis
This trial will test whether a daily phycocyanin supplement can help adults with liver fibrosis or cirrhosis by lowering liver enzymes and improving liver stiffness.
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Underdilated versus standard TIPS to prevent variceal rebleeding in cirrhosis
We will test whether using a slightly smaller TIPS stent (underdilated with a 6-mm balloon) instead of a standard stent lowers repeat variceal bleeding and reduces hepatic encephalopathy in people with cirrhosis who need TIPS.
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Using high-flow nasal cannulas to prevent oxygen drops during sedated GI endoscopy in critically ill patients
This trial will test whether high-flow nasal cannulas during sedated gastrointestinal endoscopy can prevent low oxygen levels in critically ill (ASA 3–4) adults.
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How liver failure, fibrosis, and low inorganic pyrophosphate contribute to artery calcification in people awaiting liver transplant
This study tests whether liver transplantation in people with chronic liver disease restores blood inorganic pyrophosphate and slows or stops arterial calcification.
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Health literacy and self-confidence in managing alcohol-related liver cirrhosis
This project will measure health literacy and self-confidence in adults with alcohol-related liver cirrhosis to see where extra support or education is needed.
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Using subharmonic imaging with liver stiffness and platelet count to find high-risk esophageal and gastric varices in people with cirrhosis
This tests whether combining subharmonic-assisted pressure estimation, a liver stiffness measurement, and platelet count can identify adults with liver cirrhosis who have high-risk esophageal or gastric varices.
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Handgrip strength and portal vein blood flow in people with liver cirrhosis
This trial will test whether squeezing a handgrip changes portal vein and left gastric vein pressures and blood flow in adults with liver cirrhosis to see if muscle strength affects variceal hemodynamics.
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Lowering portal pressure before liver transplant to reduce bleeding
We will test if lowering portal pressure with a TIPS procedure or with non-selective beta-blocker medication before liver transplant can reduce blood loss for adults with cirrhosis and clinically significant portal hypertension who are at higher risk of heavy bleeding.
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Metformin plus carvedilol versus carvedilol alone to lower portal pressure in cirrhosis
This trial tests whether adding metformin to carvedilol lowers portal pressure more than carvedilol alone in adults with cirrhosis who have had variceal bleeding.
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Digital early-warning system to predict acute lung injury after major liver surgery
This study will try a machine-learning based warning tool to predict early acute lung injury in adults having major liver surgery.
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CRISPR-edited donor liver transplant to reduce rejection
This trial will try transplanting deceased-donor livers that have had key HLA genes removed with CRISPR to see if they cause less rejection in adults needing a liver transplant.
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Using Holmium-166 radioembolization to treat liver cancer
This study is testing if a new type of targeted radiation treatment called Holmium-166 can help people with advanced liver cancer feel better and live longer.
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A breath test to detect liver cancer and monitor liver health
This study is testing a new breath test to see if it can help find liver cancer earlier and keep track of liver health in adults with liver issues or certain stomach symptoms.
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Examining how muscle loss affects disease progression
This study is trying to see how muscle loss affects the health and recovery of patients with liver cirrhosis, cancer, and those on breathing machines.
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Nutritional intervention for treating muscle loss in cirrhotic patients with fluid retention
This study tests whether a special nutrition plan can help people with liver cirrhosis and muscle loss feel better and live longer after a specific procedure.
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Comparing delirium rates from different anesthetics in liver transplant patients
This study is testing whether using different types of anesthesia during liver transplant surgery can help reduce the chances of patients experiencing delirium afterward.
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Using physiological parameters to predict outcomes in cirrhotic patients with gastrointestinal bleeding
This study is testing if certain health measurements can help doctors predict how well patients with liver cirrhosis and gastrointestinal bleeding will do, so they can provide better emergency care.
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Early TIPS for patients with liver cirrhosis and ascites
This study is testing if a procedure called TIPS can help people with liver cirrhosis and fluid buildup in their abdomen feel better compared to standard treatments like medications and draining the fluid.
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Using fecal microbiota transplantation to improve outcomes in patients with cirrhosis
This study is testing whether a new oral capsule treatment using healthy gut bacteria can help people with cirrhosis caused by alcohol and metabolic issues feel better and reduce their risk of infections and death.
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Comparing advice on moderate drinking versus abstention for health outcomes
This study is testing whether giving advice on moderate drinking or complete abstention is better for the health of adults over 50 in Spain.
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Using Ga-PSMA PET/MRI to assess liver cirrhosis
This study is testing a new imaging method to see if it can help doctors better understand liver function and damage in people with liver cirrhosis.
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Identifying risk factors for complications after liver transplantation
This study is trying to find out what factors can lead to bleeding and clotting problems after liver transplant surgery in patients with severe liver disease to help improve their recovery.
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Understanding healthcare use in liver cirrhosis patients
This study looks at how people with liver cirrhosis use healthcare services to better understand their needs and experiences.
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National cohort study on liver cirrhosis in Switzerland
This study is tracking patients with liver cirrhosis in Switzerland to gather important information that could help improve treatment and prevent the need for liver transplants.
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Comparing ultrasound and biomarker screening for liver cancer in patients with cirrhosis or hepatitis B
This study is testing whether ultrasound or a blood test is better at finding liver cancer early in people with cirrhosis or chronic hepatitis B.
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Combining Albumin and Enoxaparin for Patients with Decompensated Cirrhosis
This study is testing a new treatment that combines albumin and enoxaparin to see if it helps people with severe liver disease feel better compared to standard care.
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Investigating direct oral anticoagulants in patients with liver cirrhosis
This study is testing if the blood-thinning medications apixaban and edoxaban can help people with liver cirrhosis by reducing blood clotting over a week of treatment.
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Registry for patients undergoing TIPS implantation for portal hypertension
This study is collecting information from patients with serious portal hypertension who are getting a TIPS procedure to see how well it works and what complications might happen afterward.
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Investigating blood product use in liver cirrhosis patients
This study tests if giving less blood and clotting products to patients with liver cirrhosis before minor procedures is safe and helpful compared to giving more.
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Assessing muscle loss and liver health in patients with advanced liver disease
This study is testing how muscle loss affects liver health in people with advanced liver disease by looking at their body composition and overall well-being over two years.
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Hepatology home hospital program for people with advanced liver disease
This will try a hospital-at-home program that brings hepatology care to adults with cirrhosis who would otherwise need inpatient care.
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Blood test for detecting liver cancer and cirrhosis
This study is testing a new blood test to see if it can help detect liver cancer and cirrhosis in people who have or are being checked for liver issues.
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Collecting blood samples from healthy individuals and patients with cancer or benign diseases
This study is collecting blood samples from healthy people and patients with cancer or non-cancer conditions to see if certain DNA markers can help detect cancer more accurately.
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Home-based exercise guidance for patients with liver cirrhosis
This study is testing whether giving liver cirrhosis patients a structured exercise plan or just verbal advice helps them be more active after leaving the hospital.
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Using fecal microbiota transplantation to treat liver cirrhosis
This study is testing if a treatment called fecal microbiota transplantation can help people with liver cirrhosis feel better and reduce complications.
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Investigating Rivaroxaban and Apixaban in Patients with Liver Cirrhosis
This study is testing how well the blood thinners rivaroxaban and apixaban work in people with liver cirrhosis to see if they can improve treatment options for them.
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Liver transplantation outcomes for patients with severe liver failure
This study is testing how well liver transplants work for people with severe liver failure compared to those with advanced cirrhosis to see which group has better survival rates and quality of life after the transplant.
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Predicting liver failure after surgery in patients with chronic liver disease
This study is trying to find out what causes liver failure after surgery in people with chronic liver disease to help doctors better predict risks for their patients.
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Stopping proton-pump inhibitors in patients with liver cirrhosis
This study is testing whether stopping proton-pump inhibitors can reduce infection rates and brain issues in people with liver cirrhosis who have been hospitalized.
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Managing blood clotting in patients with liver cirrhosis undergoing TIPS
This study is testing a new way to manage blood clotting in patients with liver cirrhosis who are having a TIPS procedure to see if it can help reduce complications and improve their health.
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Observational study on advanced chronic liver diseases in Vienna
This study looks at patients with advanced chronic liver diseases in Vienna to see how their condition affects blood pressure in the liver and to collect samples for future research.
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Investigating the gut microbiome's role in muscle loss in liver cirrhosis patients
This study is testing how changes in gut bacteria affect muscle loss in people with liver cirrhosis and whether improving nutrition can help.
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Using Orphenadrine to Treat Muscle Cramps in Patients with Cirrhosis
This study is testing if orphenadrine can help people with cirrhosis reduce their muscle cramps and improve their quality of life.
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Effects of liver transplantation on diabetes in cirrhosis patients
This study is testing how getting a liver transplant affects blood sugar control and diabetes in people with liver cirrhosis over the next ten years.
NIH-funded research (21)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Liver Cirrhosis Network: Centers for Clinical Research
A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.
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Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
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Liver Cirrhosis Network: Longitudinal and Clinical Trial Studies
A network-wide NIH study focused on understanding cirrhosis better to prevent complications and improve care for people with advanced liver disease.
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Liver Cirrhosis Network: Coordinating Data for Better Care
A national effort is coordinating data to improve care for people with advanced liver disease and its complications.
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Liver Cirrhosis Network coordinating cirrhosis studies and a rosuvastatin trial
This project follows people with liver cirrhosis over time and tests whether the cholesterol medicine rosuvastatin helps people with cirrhosis.
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First-in-class treatment for liver cirrhosis with portal hypertension
A new therapy called XFB19 aims to reduce liver inflammation and scarring in people with advanced liver disease and portal hypertension.
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Liver cirrhosis network coordinating treatments and patient data
This program brings hospitals together to run and organize tests of treatments and care approaches for people living with liver cirrhosis.
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Using statins to lower liver cancer risk in people with cirrhosis by changing a blood protein signature
This project will see if statins can change a blood protein signature and reduce the chance of liver cancer in people with cirrhosis.
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Investigating the link between gut bacteria and liver cancer risk in people with cirrhosis.
This study is looking at how the bacteria in your gut might affect the risk of liver cancer in people with liver cirrhosis, especially in the Latinx community, and it hopes to find helpful markers that could lead to better ways to screen and prevent cancer for those at risk.
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Liver cirrhosis clinical centers network
This project follows people with cirrhosis from causes like fatty liver disease, alcohol-related liver disease, and HIV to collect medical data and samples that help spot who is at higher risk for liver complications.
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Preventing complications and cancer in people with cirrhosis
This project tests whether close clinical monitoring, detailed biospecimen collection, and long-term statin treatment can help people with compensated cirrhosis avoid liver failure and liver cancer.
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Finding ways to prevent complications in patients with cirrhosis
This study is looking for people with compensated cirrhosis to learn more about their health and behaviors, so we can better predict who might face complications and see if long-term use of statins can help prevent liver problems, all while keeping track of their progress in everyday life.
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Investigating the prevention and treatment of liver cirrhosis complications
This study is looking at ways to help people with liver cirrhosis, especially those from high-risk groups, by finding better ways to prevent complications and improve their health outcomes.
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Preventing complications of liver cirrhosis with simvastatin and AI monitoring
This project compares daily simvastatin to placebo and uses AI on clinical and imaging data to help people with compensated cirrhosis avoid complications.
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Predicting health outcomes for people with liver cirrhosis
This project will create better ways to predict which people with liver cirrhosis — especially older adults — are most likely to have hospital stays, serious complications, or die.
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Using statins to reduce liver cancer risk in patients with cirrhosis
This study is looking at whether taking statins, which are usually used to lower cholesterol, can help prevent liver cancer in people with liver cirrhosis by checking a special marker in their blood that shows their risk of developing cancer.
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Understanding and coordinating care for liver cirrhosis
This study is all about finding better ways to help people with liver cirrhosis by looking at different treatments and lifestyle changes, so we can improve their health and care.
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Understanding and preventing complications of liver cirrhosis
This study is looking for ways to help people with cirrhosis, a serious liver condition, by finding better treatments and understanding how things like race and lifestyle can affect their health, especially for those at higher risk.
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Finding ways to prevent complications in patients with cirrhosis
This study is looking for people with compensated cirrhosis to help gather information about their health and experiences, so researchers can find better ways to predict when their condition might worsen and see if long-term use of statins can help prevent serious complications.
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Investigating the progression of liver cirrhosis and its outcomes.
This study is looking at how liver cirrhosis gets worse over time in people with conditions like nonalcoholic fatty liver disease, alcohol-related liver issues, and those living with HIV, so we can find better ways to keep track of and manage their liver health.
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Investigating treatments for liver cirrhosis complications
This study is looking to help people with compensated liver cirrhosis by tracking their health over time and testing if a medication called simvastatin can improve their condition, while also using advanced technology to predict potential complications.
Related topics
Quick answers
How many Liver Cirrhosis clinical trials are recruiting right now?
57, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 33 countries. The most sites are in China (11 trials), Germany (9 trials), Austria (7 trials), United States (7 trials), Switzerland (6 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 4, Phase 4: 3, Phase 3: 3, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.