Condition

Liver Cancer clinical trials and research

• 96Clinical trials
• 89NIH research projects
• 1New in 30 days
• 22Countries

Newest Liver Cancer clinical trials

All recruiting trials (96)

• Integrated genomic and clinical database for cancer biomarker discovery

  Researchers are building a combined genomic and clinical database at Samsung Medical Center to test biomarkers for cancer diagnosis, treatment choice, and predicting how well treatments work.

  Recruiting Samsung Medical Center · Seoul, Gang-Nam · NCT07911267

• BGB-B2033 vs Sorafenib or Lenvatinib for advanced liver cancer

  This study tests whether the investigational drug BGB-B2033 can help people with advanced hepatocellular carcinoma when given after prior PD-1/PD-L1 therapy, compared with the standard medicines sorafenib or lenvatinib.

  Recruiting at 2 sites Phase 3 BeOne Medicines · South Brisbane, Queensland and 1 other locations · NCT07836530

• Protoacoustic Imaging to See Radiation Delivery in Proton Therapy

  This study tests radioacoustic imaging with ultrasound to help doctors see where proton therapy is delivering radiation for liver and prostate cancer patients.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT07832617

• YMN-136 vaccine for advanced liver, biliary tract, and pancreatic cancers

  A first-in-human dose-escalation study tests whether the YMN-136 vaccine is safe and tolerable for adults with unresectable advanced liver, biliary tract, or pancreatic cancers who have progressed on standard therapies or cannot receive them.

  Recruiting Phase 1 West China Hospital · Chengdu, Sichuan · NCT07763301

• DRAGON: International registry for patients who had combined portal and hepatic vein embolization before liver surgery

  This registry collects data on patients who had PVE/HVE before liver resection to see if it helps liver regeneration and what factors relate to outcomes.

  Recruiting at 30 sites Maastricht University Medical Center · Chicago, Illinois and 30 other locations · NCT07717437

• Precision navigation to boost cancer screening participation in high-risk communities

  This study tests whether a personalized navigation program helps adults aged 45–74 in Chinese communities who are at high risk for several cancers to complete recommended free cancer screenings.

  Recruiting at 3 sites Hunan Cancer Hospital · Huaihua, Hunan and 2 other locations · NCT07676383

• Metastatic liver cancer patient registry from multiple Chinese centers

  This is a registry that collects real-world data on adults with liver metastases to understand patterns and prognosis and to support future research.

  Recruiting at 2 sites Anhui Provincial Hospital · Bengbu, Anhui and 2 other locations · NCT07602504

• AI language tools to help tumor care teams write MDT reports

  We will test whether AI language tools can help junior cancer doctors write MDT diagnosis and treatment reports more accurately and faster.

  Recruiting at 2 sites Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong and 1 other locations · NCT07504367

• Riluzole to prevent thinking and memory problems during chemotherapy

  This pilot trial tests whether riluzole can prevent thinking and memory problems in adults with cancer receiving anthracycline- or platinum-based chemotherapy.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT07447050

• Biomarker-guided donor CAR-NK therapy targeting one or two tumor antigens for advanced solid tumors

  This treatment tries donor-derived CAR-NK cells that target one or two tumor antigens for adults with advanced solid tumors such as breast, NSCLC, colorectal, and recurrent prostate cancer.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT07410494

• Temperature-sensitive embolic agent during chemoembolization for primary liver cancer

  This trial will see if adding a temperature-sensitive embolic agent to TACE controls liver tumors as well as standard gelatin sponge particles in adults with primary liver cancer.

  Recruiting at 15 sites GrandPharma (China) Co., Ltd. · Hefei, Anhui and 14 other locations · NCT07356531

• SL-28 for Advanced Solid Tumours

  A new allogeneic cell therapy called SL-28 is being tested in adults with advanced solid tumors to see if it is safe and can help shrink tumors.

  Recruiting Phase 1/2 Second Life Therapeutics · Sydney, New South Wales and 2 other locations · NCT07341737

• Predicting Immunotherapy Response from Live Tumor Biopsies

  This project will try to see if analyzing live tumor biopsy samples kept in their 3D environment can predict whether people with advanced solid tumors will respond to immunotherapy.

  Recruiting at 7 sites Elephas · Fort Smith, Arkansas and 7 other locations · NCT07327489

• Emotional distress and immunotherapy response in liver cancer

  This project will see if emotional distress changes how well immunotherapy works for people with newly diagnosed, treatment‑naïve liver cancer.

  Recruiting Tongji Hospital · Wuhan, Hubei · NCT07325565

• Collecting blood and leftover tumor tissue to test molecular residual disease (MRD) detection

  This project will test whether blood and leftover tumor tissue from adults with certain solid tumors can be used with Natera's MRD blood tests to find tiny amounts of cancer (ctDNA) after treatment.

  Recruiting Natera, Inc. · Austin, Texas · NCT07318051

• Personalized computer-guided planning for radioembolization in liver cancer

  This project will try using patient-specific computer models of liver blood flow to predict where radioactive microspheres go during transarterial radioembolization for people with hepatocellular carcinoma.

  Recruiting University Hospital, Ghent · Ghent · NCT07315633

• Folate-targeted NIR-II carbon dot imaging to detect HCC in removed liver tissue

  This will test a folate-targeted near-infrared probe on removed liver tissue to see if it helps identify hepatocellular carcinoma margins and tiny lesions in patients undergoing radical hepatectomy.

  Recruiting West China Hospital · Chengdu, Sichuan · NCT07295340

• Transarterial ICG-guided laparoscopic anatomical liver resection for hepatocellular carcinoma

  This study tests whether using trans-arterial indocyanine green (ICG) dye to guide laparoscopic anatomical liver resection reduces cancer recurrence in people with hepatocellular carcinoma compared with the conventional portal-vein ICG method.

  Recruiting at 3 sites West China Hospital · Beijing, Beijing Municipality and 2 other locations · NCT07295275

• MRI-guided adaptive single-session radiation for liver tumors (SABR)

  This trial will test a single-session, MRI-guided adaptive high-dose radiation (SABR) for adults with primary or metastatic liver tumors to see if on-table MRI planning and replanning can treat tumors without a separate simulation visit.

  Recruiting Phase 2 Stanford University · Palo Alto, California · NCT07223307

• Tracking immune and genomic changes in liver cancer during immunotherapy

  This study will test whether blood and tumor biomarkers can predict how people with advanced hepatocellular carcinoma respond to immunotherapy.

  Recruiting Asan Medical Center · Seoul, Song-pa · NCT07186010

• Using contrast-enhanced ultrasound to check Y-90 radioembolization response in liver cancer

  This will test whether contrast-enhanced ultrasound (CEUS) can show treatment response to Y‑90 radioembolization in people with newly diagnosed hepatocellular carcinoma who are scheduled for TARE.

  Recruiting Phase 2 Thomas Jefferson University · Philadelphia, Pennsylvania · NCT07145801

• How ALPPS surgery affects liver regrowth after major liver cancer operations

  This project will follow adults with liver cancer who undergo ALPPS surgery to see if the quickly regrown liver tissue works well and how that relates to cancer coming back.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT07142213

• Testing trastuzumab deruxtecan (T‑DxD) for HER2‑positive advanced solid tumors

  This will test whether trastuzumab deruxtecan (T‑DxD) helps adults in the US with HER2‑positive (IHC 3+) locally advanced, unresectable, or metastatic solid tumors who have had prior systemic treatment and have no satisfactory alternative options.

  Recruiting at 18 sites AstraZeneca · Birmingham, Alabama and 17 other locations · NCT07124000

• Virtual exercise program to preserve function and prevent disability during chemotherapy

  This trial tests whether supervised resistance sessions by video plus short home aerobic workouts help adults 18–64 maintain strength and stay active while receiving curative-intent chemotherapy.

  Recruiting at 29 sites Alliance for Clinical Trials in Oncology · Dublin, California and 29 other locations · NCT07059884

• CRISPR-edited donor liver transplant to reduce rejection

  This trial will try transplanting deceased-donor livers that have had key HLA genes removed with CRISPR to see if they cause less rejection in adults needing a liver transplant.

  Recruiting Phase 1/2 American Organ Transplant and Cancer Research Institute LLC · Beijing, Changping · NCT07053488

• PD-1 mRNA lipid‑nanoparticle vaccine for advanced liver cancer

  This trial will try a PD‑1 mRNA vaccine delivered in lipid nanoparticles as a treatment for adults with advanced hepatocellular carcinoma who have not responded to standard therapies.

  Recruiting Phase 1 West China Hospital · Chengdu, Sichuan and 1 other locations · NCT07053072

• Histotripsy plus chemotherapy versus chemotherapy alone for colorectal cancer spread to the liver

  This trial will test whether adding noninvasive histotripsy to standard chemotherapy helps people with unresectable, liver‑confined colorectal cancer metastases stay free of disease progression longer.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07044362

• Website to teach people how to prevent liver cancer

  This project will test a website that teaches adults at risk about liver cancer prevention and lets them get a personal risk summary.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT07010315

• Direct injection of a modified vaccinia virus (vvDD-hIL2) into abdominal and gastrointestinal tumors

  This trial will try a single direct injection of a modified vaccinia virus (vvDD-hIL2) into abdominal tumors to see if it is safe for adults with advanced metastatic gastrointestinal or peritoneal cancers who have not responded to standard treatments.

  Recruiting Phase 1 Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Pittsburgh, Pennsylvania · NCT07001592

• Early multi-gene sequencing to guide therapy in advanced poor-prognosis cancers

  This trial tests whether doing broad multigene sequencing early, with tumor-board input, can help choose targeted treatments for adults with advanced pancreatic, liver, or triple-negative breast cancer.

  Recruiting University Hospital, Lille · Lille · NCT06958224

• Evaluating the effects of adjuvant therapy after surgery for liver cancer

  This study is testing if additional treatment after surgery can help people with a rare and aggressive type of liver cancer do better.

  Recruiting West China Hospital · Chengdu, Sichuan · NCT06950814

• Assessing blood biomarkers and MRI for liver cancer patients undergoing radiation therapy

  This study is testing if using special MRI scans and blood tests can help doctors keep track of liver health in patients with liver cancer who are getting radiation therapy.

  Recruiting Montefiore Medical Center · The Bronx, New York · NCT06899152

• Combining TACE and surgery for large liver tumors

  This study is testing if a treatment called TACE before surgery can help people with large liver tumors do better after surgery and have fewer chances of the cancer coming back.

  Recruiting Sun Yat-sen University · Beijing, Beijing Municipality · NCT06898398

• New treatment for advanced solid tumors using SON-DP

  This study is testing a new treatment called SON-DP to see if it can help people with advanced solid tumors, like gastric and liver cancer, by turning cancer cells into normal cells instead of just killing them.

  Recruiting at 10 sites Phase 1 Qurgen Inc. · Beijing, Beijing Municipality and 10 other locations · NCT06873659

• PSMA PET-guided Lu-177 radioligand therapy for metastatic hepatocellular carcinoma.

  This will test whether Lu-177 PSMA-617 can safely reach and shrink PSMA-positive metastatic hepatocellular carcinoma in adults whose cancer progressed after first-line treatment.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06852820

• ImmunoPET imaging for solid tumors targeting Trop2

  This study is testing a new imaging method to see if it can help diagnose solid tumors like bladder and prostate cancer better than current methods.

  Recruiting Phase 2/3 RenJi Hospital · Shanghai · NCT06851663

• Registry of liver cancer patients in China

  This study is creating a detailed database of liver cancer patients in China to help improve treatment and research for different types of liver cancer.

  Recruiting at 38 sites Anhui Provincial Hospital · Anqing, Anhui and 37 other locations · NCT06777485

• Electrochemotherapy for unresectable visceral tumors including liver metastases

  This will try electrochemotherapy with bleomycin in adults who have unresectable primary or metastatic visceral tumors, such as liver metastases.

  Recruiting Istituto Oncologico Veneto IRCCS · Padova · NCT06753136

• Imaging method for digestive system cancer using targeted PET scans

  This study is testing a new type of PET scan to see if it can better help doctors find and diagnose cancers in the digestive system.

  Recruiting RenJi Hospital · Shanghai, Shanghai Municipality · NCT06715839

• Evaluating new imaging technology for cancer radiation therapy

  This study is testing a new imaging technology for cancer radiation therapy to see if it can provide better pictures than the standard method, helping patients get more effective treatment.

  Recruiting at 4 sites Varian, a Siemens Healthineers Company · Columbus, Ohio and 3 other locations · NCT06681233

• Using brodalumab to treat immune-related side effects from cancer therapy

  This study is testing if brodalumab can help cancer patients who are having immune-related side effects from their immunotherapy treatment feel better.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06673329

• Comparing two treatments for large liver cancer

  This study is testing whether a new way of giving chemotherapy directly to the liver works better than a standard method for people with large liver cancer.

  Recruiting Sun Yat-sen University · Beijing, Beijing Municipality · NCT06641713

• AI-assisted non-contrast CT for detecting multiple cancers

  This study is testing whether an AI tool can help find different types of cancer earlier in healthy people getting routine check-ups.

  Recruiting Changhai Hospital · Shanghai, Shanghai Municipality · NCT06632886

• Exploring the links between cancer, undernutrition, and sensory changes

  This study looks at how newly diagnosed cancers in the mouth, throat, colon, and liver affect patients' nutrition and senses like taste and smell, to see how these changes impact their eating habits and quality of life.

  Recruiting Centre Hospitalier Universitaire Dijon · Dijon · NCT06600295

• Using Riluzole to Help Breast Cancer Survivors with Cognitive Issues

  This study is testing if the medication riluzole can help breast cancer survivors who are having trouble with thinking and memory feel better.

  Recruiting Phase 2 University of California, Irvine · Orange, California · NCT06580002

• Exploring imaging and tumor environment relationships in liver cancer

  This study is trying to see how imaging results relate to the tumor environment in liver cancer patients to better understand their outcomes.

  Recruiting Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Wuhan, Hubei · NCT06536998

• Combination therapy using checkpoint inhibitors for liver cancer treatment

  This study is testing a new way to treat liver cancer by combining special immune drugs with chemotherapy to see if it helps patients feel better and live longer.

  Recruiting Phase 2 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou · NCT06482801

• Software-guided immunotherapy for advanced solid tumors

  This study is testing a new AI software that suggests a mix of immunotherapy drugs for people with advanced solid tumors, like lung and liver cancers, to see if it helps them respond better to treatment while reducing side effects.

  Recruiting Phase 2/3 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT06478108

• Analyzing shopping habits to improve early cancer diagnosis

  This study is trying to see if changes in shopping habits can help spot cancer earlier by looking at purchase data from loyalty cards of people recently diagnosed with cancer and those without it.

  Recruiting Imperial College London · London · NCT06447064

• Evaluating AGX101 for advanced solid tumors

  This study is testing a new drug called AGX101 to see if it can help people with advanced solid tumors who haven't had success with other treatments.

  Recruiting at 7 sites Phase 1 Angiex, Inc. · Los Angeles, California and 6 other locations · NCT06440005

• Using DEB-TACE before liver transplantation for liver cancer treatment

  This study is testing if giving a special cancer treatment called DEB-TACE two weeks before a liver transplant can help people with liver cancer live longer without their cancer coming back.

  Recruiting Phase 4 RenJi Hospital · Shanghai · NCT06353126

• Improving early detection of liver cancer using advanced ultrasound techniques

  This study is testing new ultrasound techniques to see if they can help doctors find liver cancer earlier in adults who are already being checked for it.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT06345508

• Effect of electrical stimulation on pain and recovery after liver surgery

  This study is testing if a special electrical treatment can help reduce pain and speed up recovery for people having liver surgery for cancer.

  Recruiting West China Hospital · Chengdu, Sichuan · NCT06341270

• Testing a new drug for advanced liver cancer

  This study is testing a new drug called ETN101 to see if it can help people with advanced liver cancer who haven't had success with other treatments.

  Recruiting at 2 sites Phase 1 Etnova Therapeutics Corp. · Seoul and 1 other locations · NCT06326502

• Improving care for Black patients with gastrointestinal cancer

  This study is trying to improve cancer care for Black patients with gastrointestinal cancers by ensuring they get the right tests and treatments while helping us understand the challenges they face.

  Recruiting Case Comprehensive Cancer Center · Cleveland, Ohio · NCT06263088

• Evaluating high dose radioembolization for large inoperable liver tumors

  This study is testing if a high dose of a treatment called Y90 radioembolization can safely shrink large liver tumors that can’t be surgically removed.

  Recruiting University Hospital of Patras · Pátrai, Achaia · NCT06257030

• Treatment of advanced liver cancer using QY-1-T immunotherapy

  This study is testing a new immunotherapy called QY-1-T to see if it can help people with advanced liver cancer related to hepatitis B who haven't had success with other treatments.

  Recruiting Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · Shanghai, Shanghai Municipality · NCT06251115

• Analyzing blood and tumor markers to predict response to immunotherapy in advanced cancer

  This study is testing if blood and tumor markers can help predict how well people with advanced cancer will respond to immunotherapy treatments.

  Recruiting Gene Solutions · Ho Chi Minh City, Hồ Chí Minh and 1 other locations · NCT06227728

• CAR-γδT cell therapy targeting GPC3 and Mesothelin for cancer treatment

  This study is testing a new cancer treatment that uses modified immune cells to target specific proteins in patients with advanced solid tumors.

  Recruiting Phase 1 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT06196294

• Using AI to improve treatment for liver tumors

  This study is testing whether using artificial intelligence can help doctors choose the best treatments and predict outcomes for patients with liver tumors undergoing thermal ablation.

  Recruiting Leiden University Medical Center · Leiden · NCT06179602

• Endoscopic radiofrequency ablation for unresectable bile duct cancer

  This study tests whether adding intraductal radiofrequency ablation to standard chemotherapy and bile duct stenting helps people with unresectable bile duct cancer.

  Recruiting at 9 sites Universitätsklinikum Hamburg-Eppendorf · Berlin and 8 other locations · NCT06175845

• Detecting early liver, biliary tract, and pancreatic cancers

  This study is trying to see if a new way of testing blood samples can help find early-stage liver, biliary tract, and pancreatic cancers in people who have cancer, those with benign diseases, and healthy individuals.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06139042

• Immunotherapy using tumor-infiltrating lymphocytes for advanced liver cancer

  This study is testing a new treatment using patients' own immune cells to see if it can help people with advanced liver cancer who haven't had success with other therapies.

  Recruiting Phase 1 Tongji Hospital · Wuhan · NCT06084299

• Comparing ultrasound and biomarker screening for liver cancer in patients with cirrhosis or hepatitis B

  This study is testing whether ultrasound or a blood test is better at finding liver cancer early in people with cirrhosis or chronic hepatitis B.

  Recruiting at 18 sites Phase 4 University of Texas Southwestern Medical Center · Los Angeles, California and 18 other locations · NCT06084234

• Comparing methods to increase liver size before surgery

  This study is testing three different ways to help increase liver size before surgery for patients with liver tumors to see which method works best.

  Recruiting Medical University of Warsaw · Warsaw, Masovian Voivodeship · NCT06050200

• Acupuncture for treating nerve pain caused by chemotherapy in cancer patients

  This study is testing if acupuncture can help cancer patients with nerve pain caused by chemotherapy feel better after stopping their treatment.

  Recruiting at 9 sites GERCOR - Multidisciplinary Oncology Cooperative Group · Amiens and 14 other locations · NCT05850130

• Improving recovery after surgery with intravenous iron treatment

  This study tests if giving intravenous iron to patients who lose a lot of blood during major surgeries can help them recover better and need fewer blood transfusions.

  Recruiting Phase 3 Uppsala University Hospital · Uppsala, Sverige · NCT05744219

• Testing a new radiation therapy for liver cancer

  This study is testing a new type of radiation therapy for patients with liver cancer to see how much radiation they can safely receive while targeting the tumor effectively.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT05727787

• Evaluating blood clotting parameters in cancer patients undergoing surgery

  This study is testing how blood clotting measurements in cancer patients before and after surgery can help predict complications and outcomes for those with different types of adenocarcinoma.

  Recruiting at 2 sites University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT05517811

• Using radiofrequency to reduce liver cancer recurrence after surgery

  This study is testing if using radiofrequency during liver surgery can help prevent liver cancer from coming back and improve survival for patients with questionable surgical margins.

  Recruiting Hospital del Mar · Barcelona · NCT05492136

• Microwave ablation combined with lenvatinib for recurrent liver cancer

  This study is testing whether combining microwave ablation with the drug lenvatinib can help people with recurrent liver cancer feel better and live longer.

  Recruiting Sun Yat-sen University · Changsha, Hunan · NCT05444478

• Blood test for detecting liver cancer and cirrhosis

  This study is testing a new blood test to see if it can help detect liver cancer and cirrhosis in people who have or are being checked for liver issues.

  Recruiting at 7 sites Helio Genomics · Escondido, California and 6 other locations · NCT05199259

• Combination therapy using checkpoint inhibitors for advanced solid tumors

  This study is testing a new combination treatment using special antibodies for people with advanced solid tumors like lung and liver cancer to see if it can be safer and more effective than current options.

  Recruiting Phase 1/2 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT05187338

• Developing a markerless tracking method for real-time tumor motion measurement during radiation therapy

  This study is testing a new way to track tumor movement during radiation therapy without using markers, to see if it can help doctors target the treatment more accurately for cancer patients.

  Recruiting University of Sydney · Saint Leonards, New South Wales and 3 other locations · NCT05184790

• Fast-MRI to improve liver cancer surveillance in high-risk patients

  This trial will test whether adding a fast liver MRI to the routine six-month ultrasound finds early liver cancers sooner in adults with cirrhosis who have an annual HCC risk above 3%.

  Recruiting Assistance Publique - Hôpitaux de Paris · Bondy · NCT05095714

• Evaluating liver cancer treatments and their impact on quality of life

  This study is testing how two different liver cancer treatments affect the quality of life for patients with hepatocellular carcinoma.

  Recruiting at 2 sites Duke University · Durham, North Carolina and 1 other locations · NCT04933435

• Using virtual reality to help manage pain in GI cancer patients

  This study is testing if virtual reality can help people with GI cancer manage their severe abdominal pain better than standard treatments.

  Recruiting Cedars-Sinai Medical Center · Los Angeles, California · NCT04907643

• Engineered TILs and CAR-TILs for treating advanced solid tumors

  This study is testing a new way to treat advanced solid tumors by using specially modified immune cells from patients to see if they can better fight the cancer.

  Recruiting Phase 1 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou · NCT04842812

• Comparing preoperative and postoperative blood clot prevention for liver surgery

  This study is testing whether giving blood clot prevention medicine before or after liver surgery works better to keep patients safe from clots.

  Recruiting at 5 sites Phase 4 Helsinki University Central Hospital · Helsinki and 6 other locations · NCT04731558

• Using engineered T cells to treat pediatric solid tumors

  This study is testing a new treatment using specially modified immune cells to see if they can help children with certain types of solid tumors, like liver cancer and rhabdomyosarcoma, feel better.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT04715191

• Creating biological models to study liver diseases and tumors

  This study is trying to create new models to better understand liver diseases and tumors so that we can find better treatments for people suffering from these conditions.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Strasbourg · NCT04690972

• Using 4D-MRI to improve cancer treatment planning

  This study is testing a new type of MRI that creates 3D movies of the lungs and liver while you breathe to see if it can help doctors plan better radiation treatments for lung and liver cancer patients.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT04657042

• ET140203 T Cells for treating pediatric liver cancer

  This study is testing a new type of T-cell treatment for kids with certain types of liver cancer to see if it is safe and helps them feel better.

  Recruiting at 4 sites Phase 1/2 Eureka Therapeutics Inc. · Los Angeles, California and 3 other locations · NCT04634357

• Using MRI to improve radiation therapy planning for cancer treatment

  This study is testing whether using MRI scans can help doctors plan better radiation treatments for people with different types of cancer, like prostate and liver cancer.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT04545957

• Using advanced ultrasound techniques to improve liver cancer diagnosis

  This study is testing new ultrasound techniques to see if they can help doctors better diagnose liver cancer in patients with liver lesions.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT04409340

• Observational cohort for non-alcoholic fatty liver disease and related conditions

  This study is trying to learn more about non-alcoholic fatty liver disease and its related conditions by looking at patients with different stages of the disease and comparing them to people with diabetes and obesity who don't have it.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma, Rome/lazio/italy · NCT04371042

• Testing a new type of radiotherapy using an MR-Linac device

  This study tests a new type of radiotherapy using a special machine that combines imaging and treatment to see if it can better target tumors while protecting healthy tissue.

  Recruiting University Hospital Tuebingen · Tübingen, Baden-Wurttemberg · NCT04172753

• Using pembrolizumab to treat pediatric liver cancer

  This study is testing if the immunotherapy drug pembrolizumab can help children and young adults with liver cancer feel better and improve their condition.

  Recruiting at 5 sites Phase 2 Dana-Farber Cancer Institute · San Francisco, California and 4 other locations · NCT04134559

• Evaluating the impact of MR-guided radiation therapy on cancer treatment outcomes

  This study is testing how using a special type of radiation therapy with real-time imaging can improve treatment results and quality of life for adults with cancer.

  Recruiting at 14 sites UMC Utrecht · Pittsburgh, Pennsylvania and 17 other locations · NCT04075305

• Microwave ablation for treating small kidney and liver tumors

  This study is testing whether microwave ablation can safely and effectively treat small kidney and liver tumors in patients while they continue their regular care.

  Recruiting IRCCS San Raffaele · Milan · NCT03981497

• Infusion of immune inhibitors for liver cancer treatment

  This study is testing whether delivering immune inhibitors directly into the liver can help people with advanced liver cancer live longer and feel better compared to traditional methods.

  Recruiting Phase 3 Second Affiliated Hospital of Guangzhou Medical University · Guanzhou, Guangdong · NCT03949231

• Using 3D ultrasound for liver and kidney tumor procedures

  This study tests if using 3D ultrasound during liver and kidney tumor procedures can help doctors see better and improve the results for patients.

  Recruiting Western University, Canada · London, Ontario · NCT03844399

• Biobank for cholestatic liver diseases

  This study is collecting samples and health information from people with cholestatic liver diseases to see if it can help us better understand these conditions and improve how we detect and predict them.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT03445585

• A resource for collecting cancer data and biospecimens

  This study is creating a resource to collect health information and samples from cancer patients and healthy individuals to help improve cancer prevention and treatment strategies.

  Recruiting at 42 sites University of Nebraska · Greenwood Village, Colorado and 41 other locations · NCT02012699

• Long-term follow-up for patients previously treated with poxviral vector gene therapy

  This study is checking on the long-term health of cancer patients who received poxviral vector gene therapy to see how they are doing years later.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00451022

• Collecting blood samples from cancer patients

  This study is collecting blood samples from cancer patients to see how their immune cells change before and after chemotherapy.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00034216

NIH-funded research (newest 40 of 89)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• AI-powered liver cancer screening using ultrasound blood flow patterns

  A new AI-based method analyzes liver blood flow signals to help detect liver cancer early in people with liver disease, especially in settings with limited resources.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11638603

• Aging and liver cancer: new ways to prevent and fight hepatocellular carcinoma

  This research explores how aging promotes liver cancer and tests new preventive approaches that could help people at higher risk due to age.

  NIH research Sanford Burnham Prebys Medical Discovery Institute · La Jolla, United States · NIH-11602178

• Testing new therapies for pediatric and young adult sarcoma, kidney, and liver cancers

  Researchers are testing new drugs and smart combinations in models of pediatric cancers to help guide future treatments for kids and young adults.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11538882

• Liver cancer prevention and care in Uganda using HIV clinic networks

  A program in Uganda uses existing HIV care systems to roll out liver cancer prevention, screening, and treatment strategies tailored to local needs.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11535354

• Leveraging HIV care to prevent liver cancer in Uganda

  A program in Uganda uses existing HIV care clinics to roll out a liver cancer prevention and treatment plan tailored to local needs.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11535353

• Damaged telomeres and telomerase in liver scarring and liver cancer

  Using human stem-cell models, researchers look at how short telomeres and telomerase changes can lead to liver scarring and liver cancer for people with telomere-related risks.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11471612

• Liver cancer prevention and care in Uganda using HIV clinic resources

  A project to bring proven liver cancer prevention and care steps into HIV clinics in Uganda to reduce liver cancer deaths.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11413342

• Partnership to Prevent Liver Cancer in Pascua Yaqui Communities

  A community-engaged effort with the Pascua Yaqui Tribe to prevent liver cancer by combining Yoeme knowledge with scientific methods and focusing on AI adults in the Southwest.

  NIH research University of Arizona · Tucson, United States · NIH-11411428

• Liver Cancer Early Detection Program: Data & Coordination Center for Biomarker Research

  A national group coordinates data, biobanks, and biomarker research to improve early detection of liver cancer in people with cirrhosis.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11406291

• Liver Cancer SPORE at UT Southwestern: new paths to prevention and treatment for hepatocellular carcinoma

  A dedicated UT Southwestern effort aims to reduce deaths from liver cancer by combining basic science with clinical trials to prevent cancer in high-risk patients and improve treatments.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11406288

• Early detection of liver cancer using blood, imaging, and clinical data

  Aims to improve early detection of liver cancer (HCC) by combining blood markers, imaging, and patient information to catch the disease earlier.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11406158

• Pre-Targeting Radiopharmaceutical Therapy for Liver Cancer

  A patient-facing program aims to test a two-step radiotherapy approach that targets liver cancer more precisely while reducing side effects.

  NIH research Zeest Bio INC · Watertown, United States · NIH-11405078

• Partnership to Prevent Liver Cancer in Pascua Yaqui and AIAN Communities

  A community-led effort to reduce liver cancer risk in AI/AN adults by understanding attitudes, measuring NAFLD risk, and testing a tailored lifestyle program in clinics.

  NIH research Northern Arizona University · Flagstaff, United States · NIH-11405050

• Early detection and risk stratification of liver cancer using AI in cirrhosis patients

  This project uses an AI system on data from thousands of people with cirrhosis to identify who is at high risk for liver cancer and to catch it early.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11398195

• Using HIV clinics in Uganda to prevent and detect liver cancer

  This project brings hepatitis B screening, birth-dose vaccination, and liver cancer checks into HIV care clinics in Uganda to help people with or at risk for HBV and HIV get earlier care.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11385065

• Bringing liver cancer prevention and care into HIV clinics in Uganda

  This project brings hepatitis B screening, vaccination, and earlier liver cancer detection and treatment into HIV care clinics to help people in Uganda stay healthier.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11385064

• Precision liver cancer models using CRISPR edits in human liver cells

  A new NIH-funded project aims to create better patient-friendly liver cancer models by editing primary human liver cells to mimic the genetic diversity seen in Hepatocellular Carcinoma (HCC).

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11373656

• AI-Enhanced Perfusion MRI to Improve Y90 Particle Distribution in Liver Cancer Treatment

  A cutting-edge imaging tool uses artificial intelligence to better predict how Y-90 beads spread in liver tumors to improve radioembolization therapy.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11368811

• Early detection of liver cancer risk in people with cirrhosis and MASLD

  A small research grant to explore better ways to find liver cancer early among people with cirrhosis and MASLD so they can get timely care.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11356187

• Cyanobacteria, cyanotoxins, and liver cancer development

  This grant explores whether exposure to blue-green algae and their toxins may contribute to liver cancer risk in adults, especially where metabolic disease is present.

  NIH research University of Hawaii at Manoa · Honolulu, United States · NIH-11326246

• Targeting mutant IDH1 in bile duct (cholangiocarcinoma) and other solid cancers

  Researchers are trying combinations of medicines that block mutant IDH1 to help people with cholangiocarcinoma and other cancers that carry IDH1 mutations.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11321278

• Small LIVER Cancer: Practical solutions to speed up care for early hepatocellular cancer

  A clinician-investigator is being trained to find real-world ways to help people with small liver cancer get guideline-concordant treatment more quickly.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11300179

• Real-time guided proton radiation for more precise liver tumor treatment

  Trying a proton radiation approach that tracks liver tumors in real time to treat people with liver cancer more precisely while protecting healthy liver tissue.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11294260

• Exosome-based targeted imaging and alpha therapy for liver cancer

  A new approach uses tiny natural exosome particles to carry an alpha-particle drug plus an imaging label to find and treat hard-to-remove liver tumors.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11285203

• Enhancing liver cancer treatment with moderate-dose radiotherapy

  A small, patient-focused study will look at how giving moderate doses of radiation to liver tumors might improve blood flow and help other treatments work better.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11284730

• Helping liver cancer treatments work better by targeting the LIFR–LCN2 pathway

  This project is testing whether fixing the LIFR–LCN2 pathway can make treatments for hepatocellular carcinoma (liver cancer) more effective.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11250016

• How short telomeres and telomerase reactivation drive liver scarring and cancer

  This project looks at how short telomeres and reactivated telomerase cause liver scarring and hepatocellular carcinoma using human stem-cell models to help people at risk of liver cancer.

  NIH research Washington University · Saint Louis, United States · NIH-11248004

• AI-powered liver cancer screening using arterial blood flow patterns

  A new AI-based method analyzes liver blood flow to help detect liver cancer early in people with liver disease, aiming to be low-cost and easy to use.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11241817

• Immune cells linked to liver cancer in people with HIV

  Developing treatments that target a specific immune cell to help people with liver cancer who also have HIV.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11241102

• How a cell-cleanup pathway in liver support cells affects immune activity against liver cancer

  This project tests whether changing a cellular cleanup system in liver support cells can help immune cells better attack hepatocellular carcinoma.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11229787

• Liver cancer prevention partnership with the Pascua Yaqui Tribe

  Working with the Pascua Yaqui community to try new ways to lower liver cancer risk among American Indian adults.

  NIH research University of Arizona · Tucson, United States · NIH-11195140

• Partnership to prevent liver cancer with Pascua Yaqui communities

  This project works with Pascua Yaqui and other American Indian and Alaska Native adults to check how common fatty liver is, learn about liver cancer risks, and adapt a proven lifestyle program to lower those risks.

  NIH research Northern Arizona University · Flagstaff, United States · NIH-11195086

• Blood tests plus MRI image analysis to find liver cancer earlier

  This project combines new blood-based 'liquid biopsy' tests with advanced MRI image analysis to try to detect liver cancer earlier in people at high risk, such as those with cirrhosis.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11187129

• Early detection and risk prediction for liver cancer

  This project works to find who with cirrhosis is most likely to develop liver cancer and to catch tumors earlier using clinical data, scans, blood tests, and AI tools.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11182487

• Bringing liver cancer prevention and care into HIV clinics in Uganda

  This project adds hepatitis B testing, birth-dose vaccination, and liver cancer screening to HIV clinics in Uganda to help people with HIV and hepatitis B get earlier care.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11181618

• Consortium hub for early liver cancer detection and data coordination

  This project builds a central hub that helps researchers find and confirm blood and tissue markers to catch liver cancer earlier in people with cirrhosis.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11178110

• Imaging biomarkers to guide combined local therapy and immunotherapy for liver cancer

  This project will develop advanced imaging tests to help doctors time and personalize combined catheter-based liver treatments and immunotherapy for people with hepatocellular carcinoma.

  NIH research Yale University · New Haven, United States · NIH-11174540

• UCLA Center for Early Liver Cancer Detection

  This project combines a new blood-based DNA test with imaging and medical records to find liver cancer earlier in people at high risk, such as those with cirrhosis or chronic hepatitis B.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11174506

• How aging immune signals and bile acids weaken T cell attack on liver cancer

  This work looks at whether long-term interferon signals and buildup of bile acids in older adults make T cells less able to fight liver cancer.

  NIH research Sanford Burnham Prebys Medical Discovery Institute · La Jolla, United States · NIH-11160735

• Abnormal DNA fragments that may drive age-related liver cancer

  Researchers are exploring whether small pieces of DNA that leak into cells cause inflammation and liver cancer in older adults, and whether blocking that process could help people with fatty liver disease or reduce risk of hepatocellular carcinoma.

  NIH research Sanford Burnham Prebys Medical Discovery Institute · La Jolla, United States · NIH-11160733

Related topics

Quick answers

How many Liver Cancer clinical trials are recruiting right now?

96, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 22 countries. The most sites are in United States (35 trials), China (33 trials), Australia (5 trials), Canada (5 trials), France (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 11, Phase 2: 7, Phase 1/2: 5, Phase 4: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →