Finding ways to prevent complications in patients with cirrhosis
Official title: Strategies and Therapies for Outcomes Prevention in Cirrhosis: The STOP-C Liver Cirrhosis Network
Funded at Weill Medical Coll of Cornell Univ · NIH-10909129 · Data updated 2026-11-12
This study is looking for people with compensated cirrhosis to help gather information about their health and experiences, so researchers can find better ways to predict when their condition might worsen and see if long-term use of statins can help prevent serious complications.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 23, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $419,793 |
| NIH project number | 5U01DK130221-04 |
| Project ID | NIH-10909129 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with compensated cirrhosis, including those with non-alcoholic steatohepatitis (NASH), alcoholic liver disease (ALD), cholestatic, and cryptogenic cirrhosis.
✕Less likely to help
Patients with decompensated cirrhosis or those not diagnosed with any form of cirrhosis may not benefit from this research.
What this research studies
This research focuses on creating a cohort of patients with compensated cirrhosis to gather clinical, behavioral, and biomarker data. By analyzing this data, the researchers aim to develop prediction models that can forecast clinical decompensation and validate the effectiveness of long-term statin therapy in preventing complications like hepatic decompensation and hepatocellular carcinoma. Patients will be monitored for their health outcomes, and their experiences will contribute to a better understanding of cirrhosis progression and treatment efficacy.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing serious complications in patients with cirrhosis.
How similar studies have gone: Previous research has shown promise in using cohort studies and biomarker analysis to improve outcomes in liver disease, indicating that this approach has potential for success.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Brown, Robert S — Weill Medical Coll of Cornell Univ
- Study coordinator: Brown, Robert S
Related research
Other NIH-funded projects on the same topics.
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Liver Cirrhosis Network: Centers for Clinical Research
A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.
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Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
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Liver Cirrhosis Network: Longitudinal and Clinical Trial Studies
A network-wide NIH study focused on understanding cirrhosis better to prevent complications and improve care for people with advanced liver disease.
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Liver Cirrhosis Network: Coordinating Data for Better Care
A national effort is coordinating data to improve care for people with advanced liver disease and its complications.
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Liver Cirrhosis Network coordinating cirrhosis studies and a rosuvastatin trial
This project follows people with liver cirrhosis over time and tests whether the cholesterol medicine rosuvastatin helps people with cirrhosis.
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First-in-class treatment for liver cirrhosis with portal hypertension
A new therapy called XFB19 aims to reduce liver inflammation and scarring in people with advanced liver disease and portal hypertension.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.