Investigating the progression of liver cirrhosis and its outcomes.
Official title: Liver Cirrhosis Network: Clinical Research Centers
Funded at Virginia Commonwealth University · NIH-10909124 · Data updated 2026-11-12
This study is looking at how liver cirrhosis gets worse over time in people with conditions like nonalcoholic fatty liver disease, alcohol-related liver issues, and those living with HIV, so we can find better ways to keep track of and manage their liver health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | September 13, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $213,145 |
| NIH project number | 5U01DK130134-04 |
| Project ID | NIH-10909124 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with compensated cirrhosis, particularly those with NASH, ALD, or HIV.
✕Less likely to help
Patients with liver cirrhosis who are not compensated or those with other unrelated liver conditions may not benefit from this research.
What this research studies
This research focuses on understanding how liver cirrhosis progresses, particularly in patients with nonalcoholic steatohepatitis (NASH), alcohol-induced liver disease (ALD), and those living with HIV. It involves a multicenter, observational approach where patients with compensated cirrhosis will be enrolled and followed over time. The study aims to collect data and biological samples to evaluate various factors that contribute to the progression of cirrhosis and its associated clinical events. By identifying these factors, the research seeks to develop better tools for monitoring and managing liver disease.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for patients with liver cirrhosis.
How similar studies have gone: Other research has shown promise in understanding liver disease progression using similar observational approaches, indicating potential for success in this study.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Sanyal, Arun J — Virginia Commonwealth University
- Study coordinator: Sanyal, Arun J
Related research
Other NIH-funded projects on the same topics.
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Liver Cirrhosis Network: Centers for Clinical Research
A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.
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Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
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Liver Cirrhosis Network: Longitudinal and Clinical Trial Studies
A network-wide NIH study focused on understanding cirrhosis better to prevent complications and improve care for people with advanced liver disease.
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Liver Cirrhosis Network: Coordinating Data for Better Care
A national effort is coordinating data to improve care for people with advanced liver disease and its complications.
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Liver Cirrhosis Network coordinating cirrhosis studies and a rosuvastatin trial
This project follows people with liver cirrhosis over time and tests whether the cholesterol medicine rosuvastatin helps people with cirrhosis.
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First-in-class treatment for liver cirrhosis with portal hypertension
A new therapy called XFB19 aims to reduce liver inflammation and scarring in people with advanced liver disease and portal hypertension.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.