Liver Cirrhosis Network coordinating cirrhosis studies and a rosuvastatin trial
Official title: Liver Cirrhosis Network: Scientific and Data Coordination Center
Funded at Northwestern University · NIH-11473501 · Data updated 2026-11-12
This project follows people with liver cirrhosis over time and tests whether the cholesterol medicine rosuvastatin helps people with cirrhosis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | August 28, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2026 |
| Award (this year) | $274,035 |
| NIH project number | 3U24DK130164-05S1 |
| Project ID | NIH-11473501 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with a diagnosis of liver cirrhosis who meet the study's health and medication eligibility rules would be the main candidates for participation.
✕Less likely to help
People without liver cirrhosis or those who are medically ineligible (for example due to severe liver failure, conflicting medications, or pregnancy) would not be expected to benefit from joining this trial.
What this research studies
You would be part of a large group of people with liver cirrhosis who are followed over time to understand how the disease progresses. A smaller randomized trial within the network gives some participants rosuvastatin and others a matching placebo so researchers can compare outcomes. Northwestern University runs the central data and science coordination, including study design, monitoring, and statistical analysis. The team also manages drug supply and matching placebo pills so the trial can be run safely and fairly.
Why it matters
Potential benefit: If successful, this work could show whether rosuvastatin is safe and can reduce complications or improve outcomes for people with cirrhosis.
How similar studies have gone: Observational studies have suggested benefits of statins in cirrhosis but randomized trials are limited, so this trial builds on promising but not yet conclusive prior evidence.
Where this research is happening
-
Northwestern University
Chicago, United States Active
Researchers
- Principal investigator: Smith, Abigail — Northwestern University
- Study coordinator: Smith, Abigail
Related research
Other NIH-funded projects on the same topics.
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Liver Cirrhosis Network: Centers for Clinical Research
A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.
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Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
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Liver Cirrhosis Network: Longitudinal and Clinical Trial Studies
A network-wide NIH study focused on understanding cirrhosis better to prevent complications and improve care for people with advanced liver disease.
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Liver Cirrhosis Network: Coordinating Data for Better Care
A national effort is coordinating data to improve care for people with advanced liver disease and its complications.
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First-in-class treatment for liver cirrhosis with portal hypertension
A new therapy called XFB19 aims to reduce liver inflammation and scarring in people with advanced liver disease and portal hypertension.
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Liver cirrhosis network coordinating treatments and patient data
This program brings hospitals together to run and organize tests of treatments and care approaches for people living with liver cirrhosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.